Results 91 to 100 of about 32,838 (155)

VIP contribution to the decidualization program: regulatory T cell recruitment [PDF]

, 2014
During early pregnancy, the human uterus undergoes profound tissue remodeling characterized by leukocyte invasion and production of proinflammatory cytokines, followed by tissue repair and tolerance maintenance induction.
Agüero, Mariana, Grasso, Esteban Nicolas, Mor, Gil, Paparini, Daniel Esteban, Perez Leiros, Claudia, Ramhorst, Rosanna Elizabeth   +5 more
core   +1 more source

Targeting EZH2 in Cancer: From Molecular Mechanisms to Clinical Translation

MedComm – Oncology, Volume 5, Issue 2, June 2026.
The abnormal overexpression or gain‐of‐function mutations of EZH2 play a significant role in cancer occurrence and progression, highlighting the importance and potential of EZH2 as a cancer biomarker. Therefore, screening for effective and safe small‐molecule inhibitors, degraders, and natural compounds targeting EZH2 through preclinical cancer models ...
Xi Zhong, Jieni Li, Mingxuan Pan, Xiaoxue Ke, Hongjuan Cui   +4 more
wiley   +1 more source

Pharmacological activation of FOXO3 suppresses triple-negative breast cancer in vitro and in vivo [PDF]

, 2016
Triple-negative breast cancer (TNBC) is the most lethal form of breast cancer. Lacking effective therapeutic options hinders treatment of TNBC. Here, we show that bepridil (BPD) and trifluoperazine (TFP), which are FDA-approved drugs for treatment of ...
Berek, Jonathan S, Chung, Young Min, Hu, Mickey C-T, Ma, Jessica, Park, See-Hyoung, Yang, Qin   +5 more
core   +2 more sources

Gene‐specific double‐stranded RNAs induce mortality in the South African mealybug Delottococcus aberiae

Pest Management Science, Volume 82, Issue 6, Page 5184-5194, June 2026.
Gene‐specific double‐stranded RNAs effectively silence essential genes in the invasive citrus pest Delottococcus aberiae, leading to significant mortality through both microinjection and oral delivery. These results provide proof of concept for RNA interference‐based biopesticides as selective and sustainable tools for citrus integrated pest management.
Carolina Gallego‐Giraldo, Alberto Urbaneja, Omar Ruíz‐Rivero, Verónica Aragonés, Marie Guijarro‐Guijarro, José‐Antonio Daròs, Meritxell Perez‐Hedo   +6 more
wiley   +1 more source

Dopamine D2 Receptor Agonists as Modulators of VEGF‐A‐Driven Angiogenesis: Mechanisms, Clinical Evidence, and Translational Opportunities

The FASEB Journal, Volume 40, Issue 9, 15 May 2026.
Interplay between VEGF‐A‐driven angiogenesis and DRD2‐mediated inhibition. Tumor‐derived VEGF‐A activates VEGFR2 on endothelial cells, triggering proangiogenic signaling pathways that promote abnormal vessel growth and vascular leakage. VEGF‐A also induces DRD2 expression, establishing a feedback mechanism.
Venu Akkanapally, Aman Kumar, Inemai Ezhil, Manas Ranjan Sahu, Xue‐Feng Bai, Kamal S. Pohar, Sujit Basu   +6 more
wiley   +1 more source

Age‐Dependent Alterations of Chromosomal Passenger Complex Members During Implantation and Decidualization in the Mouse Uterus

Aging Cell, Volume 25, Issue 5, May 2026.
Aging in females reduces the number of implantation sites and leads to specific, compartment‐dependent changes in components of the chromosomal passenger complex (pIncenp, Aurora B, Survivin, Borealin) during mouse uterine implantation and decidualization.
Ezgi Golal, Cemre Nur Balci, Nuray Acar
wiley   +1 more source

The Multifaceted Role of Keratinocytes in Hidradenitis Suppurativa Pathogenesis

Experimental Dermatology, Volume 35, Issue 5, May 2026.
ABSTRACT Hidradenitis suppurativa (HS) is a chronic autoinflammatory skin disorder of the pilosebaceous unit, with multiple factors contributing to its onset, activity and progression. Alongside a predisposing genetic background, hormonal and microbiome alterations, dysregulation of innate and adaptive immune response, as well as environmental ...
Chiara Moltrasio, Angelo Valerio Marzano, Maurizio Romagnuolo   +2 more
wiley   +1 more source

The Role of sptf-3 in C. elegans Growth and Development [PDF]

, 2011
The Sp family of transcription factors has important functions during development in animals. In the nematode Caenorhabditis elegans there are three Sp-related transcription factors (Sptf) which perform similarly important roles in development.
Ulm, Elizabeth
core  

Klf15 Is Critical for the Development and Differentiation of Drosophila Nephrocytes [PDF]

, 2015
Insect nephrocytes are highly endocytic scavenger cells that represent the only invertebrate model for the study of human kidney podocytes. Despite their importance, nephrocyte development is largely uncharacterised.
A Halme, AC Crossley, Achim Paululat, AD Alvarez, AJ Vilella, AS Tutor, B Wang, BB McConnell, C Burnett, C Lehmacher, D Das, D Das, D Jeyaraj, D Jeyaraj, D Leiss, DA Kimbrell, EJ Ward, F Grahammer, F Zhang, GG Neely, H Weavers, HY Lim, J Sellin, J Sellin, James H. Catterson, Jessica R. Ivy, JH Catterson, JL Brown, Karen Ocorr, KK Sorensen, LJ Zhu, M Helmstadter, M Togel, Maik Drechsler, P Tomancak, Paul S. Hartley, Q He, Rolf Bodmer, Ruben Artero, S Fisch, S Haralalka, S Zaffran, S Zhuang, SE McGuire, SF Soukup, SK Aggarwal, SK Mallipattu, SK Sasse, VB Wigglesworth, VR Chintapalli, VY Arshavsky, X Gao, Z Han, Z Han   +53 more
core   +3 more sources

Beyond the chaos: How architecture structures tumour biology

The FEBS Journal, Volume 293, Issue 9, Page 2519-2540, May 2026.
Tissue architecture shapes tumour initiation and progression through multiple interconnected layers continuously remodelled over time. This review outlines how physical forces, biochemical cues, cellular niches and systemic influences contribute to tumour evolution.
Lea Dörner, Catrin Lutz, Stefan Prekovic, Hendrik A. Messal   +3 more
wiley   +1 more source