Results 71 to 80 of about 32,838 (155)

Harnessing Natural Compounds in Psoriasis: Targeting Cellular Pathways for Effective Therapy

Phytotherapy Research, EarlyView.
Natural compounds act on key cellular pathways in psoriasis by suppressing keratinocyte hyperproliferation, modulating Th17/IL‐17‐mediated immune responses, and reducing oxidative stress. These multi‐target effects highlight their potential as safer adjunctive therapies alongside conventional treatments.
Hye Jin Lee, Yu Jin So, Il‐Joo Jo, Ji Yong Jang, Tae Han Yook, Jun Ho Lee, Sung Wook Kim, Kangwook Lee, Soo Jung Park, Gabsik Yang   +9 more
wiley   +1 more source

Occurrence and Significance of the Nuclear Transcription Factor Krüppel-Like Factor 4 (KLF4) in the Vessel Wall

Acta Medica, 2009
Practically all mammalian cells including human can switch, according to micro- or macroenvironmental conditions, from states of cellular quiescence to inflammatory activation and vice versa.
Pavel Kuneš, Zdeňka Holubcová, Jan Krejsek   +2 more
doaj   +1 more source

Secretome analysis of breast cancer-associated adipose tissue to identify paracrine regulators of breast cancer growth [PDF]

, 2017
Adipose tissue secretes a plethora of adipokines as evidenced by characterization of subcutaneous and visceral adipose tissue secretomes. However, adipose tissue composition and secretion pattern is depot and disease dependent, influencing the adipose ...
Bracke, Marc, Braems, Geert, Cocquyt, Veronique, De Wever, Olivier, Denys, Hannelore, Hendrix, An, Lapeire, Lore, Lecoutere, Evelyne, Maynard, Dawn, Müller, Cathérine, Van Bockstal, Mieke, Van den Broecke, Rudy, Vandesompele, Jo   +12 more
core   +2 more sources

Update on Non‐Biological and RNA‐Based Therapeutics in Chronic Inflammatory Diseases: Precision Medicine Through Small Molecules: An EAACI Position Paper

Allergy, EarlyView.
ABSTRACT In the last decades, critical advancements in research technology and knowledge on disease mechanisms steered therapeutic approaches for chronic inflammatory diseases towards unprecedented target specificity. For allergic and chronic lung diseases, biologic drugs pioneered this goal, acquiring on the way—through the clinical use of monoclonal ...
F. Roth‐Walter, I. M. Adcock, C. Benito‐Villalvilla, R. Bianchini, L. Bjermer, G. Caramori, L. Cari, K. F. Chung, Z. Diamant, I. Eguiluz‐Gracia, E. F. Knol, M. Jesenak, F. Levi‐Schaffer, G. Nocentini, L. O'Mahony, O. Palomares, F. Redegeld, M. Sokolowska, B. Van Esch, M. Zurlo, C. Stellato   +20 more
wiley   +1 more source

Doxycycline inducible Krüppel-like factor 4 lentiviral vector mediates mesenchymal to epithelial transition in ovarian cancer cells. [PDF]

PLoS ONE, 2014
Ovarian cancer presents therapeutic challenges due to its typically late detection, aggressive metastasis, and therapeutic resistance. The transcription factor Krüppel-like factor 4 (KLF4) has been implicated in human cancers as a tumor suppressor or ...
Zixuan Chen, Yinan Wang, Wen Liu, Guannan Zhao, Suechin Lee, Andrea Balogh, Yanan Zou, Yuqi Guo, Zhan Zhang, Weiwang Gu, Chengyao Li, Gabor Tigyi, Junming Yue   +12 more
doaj   +1 more source

Global gene expression profiling of brown to white adipose tissue transformation in sheep reveals novel transcriptional components linked to adipose remodeling [PDF]

, 2015
BACKGROUND: Large mammals are capable of thermoregulation shortly after birth due to the presence of brown adipose tissue (BAT). The majority of BAT disappears after birth and is replaced by white adipose tissue (WAT).
Basse, Astrid L., Dixen, Karen, Gupta, Ramneek, Hansen, Jacob B., Kristiansen, Karsten, Quistorff, Bjorn, Qvortrup, Klaus, Tygesen, Malin P., Wang, Jun, Yadav, Rachita   +9 more
core   +3 more sources

Elevated CO2 and Temperature Alter Grass Pollen's Ability to Modify Transcriptome and Function of the Nasal Epithelium

Allergy, EarlyView.
We exposed human nasal epithelial tissues to pollen from grasses grown under different climate treatments (temperature and CO2). Pollen weakened epithelial tight junctions and altered cytokine‐related gene expression, with similar protein‐level effects.
Tarleena Tossavainen, Tanja Turunen, Maria‐Viola Martikainen, Miisa Kankaanpää, Marjo Malinen, Marjut Roponen   +5 more
wiley   +1 more source

Polycystic Ovary Syndrome in Overweight and Normal Weight Women: The Relationships with Inflammatory Markers

Bagcilar Medical Bulletin, 2020
Objective:The etiology and pathophysiology of Polycystic Ovary syndrome (PCOS) are not yet clearly explained as the disease has a heterogeneous clinical presentation. Several cytokines produced by the ovary and other tissues contribute to the maintenance
Tolga Atakul, Özgür Deniz Turan, Çiğdem Yenisey   +2 more
doaj   +1 more source

A genetic risk score based on BCL11A and HBS1L‐MYB variants predicts clinical severity in Brazilian sickle cell anaemia patients

British Journal of Haematology, EarlyView.
Summary Individuals with sickle cell anaemia (SCA) exhibit significant clinical heterogeneity influenced by several factors, especially fetal haemoglobin (HbF) levels. Variations in adult HbF levels are partly explained by the co‐inheritance of genetic variants that regulate globin expression.
Gabriela S. Arcanjo, Alexsandro P. Silva, Madi V. Diniz, Igor F. Domingos, Diego A. Pereira‐Martins, Amanda B. Araújo, Talita S. S. França, Ana C. Anjos, Aderson S. Araujo, Edis Belini‐Junior, Sara T. O. Saad, Fernando F. Costa, Antonio R. Lucena‐Araujo, Marcos André C. Bezerra   +13 more
wiley   +1 more source

MircoRNA-145 promotes activation of hepatic stellate cells via targeting krüppel-like factor 4

Scientific Reports, 2017
Krüppel-like Factor 4 (KLF4), a target gene of miR-145, can negatively regulate lung fibrosis. However, the potential role of KLF4 and miR-145 in hepatic stellate cells (HSCs) activation or in hepatic fibrosis keeps unclear.
Ruoting Men, Maoyao Wen, Mingyue Zhao, Xuelian Dan, Zongze Yang, Wenchao Wu, Maggie Haitian Wang, Xiaojing Liu, Li Yang   +8 more
doaj   +1 more source