Results 71 to 80 of about 882,731 (192)

Inhibition of Ubiquitin Ligase F-box and WD Repeat Domain-containing 7α (Fbw7α) Causes Hepatosteatosis through Krüppel-like Factor 5 (KLF5)/Peroxisome Proliferator-activated Receptor γ2 (PPARγ2) Pathway but Not SREBP-1c Protein in Mice [PDF]

, 2011
F-box and WD repeat domain-containing 7α (Fbw7α) is the substrate recognition component of a ubiquitin ligase that controls the degradation of factors involved in cellular growth, including c-Myc, cyclin E, and c-Jun.
Ema Masatsugu, Iwasaki Hitoshi, Karasawa Tadayoshi, Kobayashi Kazuto, Kumadaki Shin, Matsuzaka Takashi, Nakagawa Yoshimi, Nakakuki Masanori, Saito Ryo, Shimano Hitoshi, Sone Hirohito, Suzuki Hiroaki, Takahashi Akimitsu, Takahashi Satoru, Takekoshi Kazuhiro, Yahagi Naoya, Yamada Nobuhiro, Yatoh Shigeru, 中川 嘉, 依馬 正次, 小林 和人, 山田 信博, 岩﨑 仁, 島野 仁, 曽根 博仁, 松坂 賢, 矢作 直也, 矢藤 繁, 竹越 一博, 鈴木 浩明, 高橋 昭光, 高橋 智   +31 more
core   +1 more source

Somatic cell reprogramming for Parkinson's disease treatment

Ibrain, Volume 11, Issue 1, Page 59-73, Spring 2025.
The fundamental purpose of cell reprogramming to treat Parkinson's disease is to generate dopaminergic neurons (DAN) and do transplantation. There are two ways to accomplish this. One method is to induce cells into induced DA neurons (iDAN) directly or to induce cells into induced pluripotent stem cells and ultimately into iDAN in vitro. Another option
Xiaozhuo Li, Kevin Fang, Fengping Wang
wiley   +1 more source

Krüppel-like factor 4 control of immune cell function

Frontiers in Immunology
Krüppel-like factor 4 (KLF4) belongs to a family of transcription factors that contain conserved zinc finger DNA binding domains, including specificity proteins (SPs) and Krüppel-like factors (KLFs).
Tapatee Das, Elaine Wang, Yitian Xu, Harrison Yang, Xudong Liao, Mukesh K. Jain, Mukesh K. Jain   +6 more
doaj   +1 more source

Reprogramming of rabbit induced pluripotent stem cells toward epiblast and chimeric competency using Krüppel-like factors

Stem Cell Research, 2017
Rabbit induced pluripotent stem cells (rbiPSCs) possess the characteristic features of primed pluripotency as defined in rodents and primates. In the present study, we reprogrammed rbiPSCs using human Krüppel-like factors (KLFs) 2 and 4 and cultured them
Yann Tapponnier, Marielle Afanassieff, Irène Aksoy, Maxime Aubry, Anaïs Moulin, Lucas Medjani, Wilhelm Bouchereau, Chloé Mayère, Pierre Osteil, Jazmine Nurse-Francis, Ioannis Oikonomakos, Thierry Joly, Luc Jouneau, Catherine Archilla, Barbara Schmaltz-Panneau, Nathalie Peynot, Harmonie Barasc, Alain Pinton, Jérome Lecardonnel, Elen Gocza, Nathalie Beaujean, Véronique Duranthon, Pierre Savatier   +22 more
doaj   +1 more source

Secretome analysis of breast cancer-associated adipose tissue to identify paracrine regulators of breast cancer growth [PDF]

, 2017
Adipose tissue secretes a plethora of adipokines as evidenced by characterization of subcutaneous and visceral adipose tissue secretomes. However, adipose tissue composition and secretion pattern is depot and disease dependent, influencing the adipose ...
Bracke, Marc, Braems, Geert, Cocquyt, Veronique, De Wever, Olivier, Denys, Hannelore, Hendrix, An, Lapeire, Lore, Lecoutere, Evelyne, Maynard, Dawn, Müller, Cathérine, Van Bockstal, Mieke, Van den Broecke, Rudy, Vandesompele, Jo   +12 more
core   +2 more sources

β‐Aminoisobutyric Acid Alleviates Cisplatin‐Induced Muscle Atrophy by Regulating E3 Ubiquitin Ligases, Apoptosis, Amino Acid Metabolism, Autophagy, and Ferroptosis

Medicine Bulletin, EarlyView.
ABSTRACT Background Cisplatin (CIS) is a widely used broad‐spectrum anticancer agent, but its clinical application is often limited by severe adverse effects, including skeletal muscle atrophy, which compromises patients' quality of life and treatment efficacy.
Hao‐Zhe Wang, Wen‐Bi He, Huan Wang, Hao Wang, Wen‐Jun Fang, Meng‐Qian Li, Jiong‐Xing Huang, Fei‐Peng Chen, Hui‐Guo Wang, Lin Zhu, Xiao‐Guang Liu   +10 more
wiley   +1 more source

Downregulation of KLF8 expression by shRNA induces inhibition of cell proliferation in CAL27 human oral cancer cells [PDF]

, 2013
Objectives: KLF8 is a member of KLF transcription factors which play an important tolr in oncogenesis. It is barely expressed in normal human epithelial cells but highly overexpressed in several types of human cancer cell lines.
Bin, Zhang, Chun-Peng, Xia, Dao-Ying, Yuan, Ke-Yi, Li, Li-Cheng, Jiang, Shu-Wei, Liu, Wei-Feng, Zhang, Xian-Bin, Liu   +7 more
core   +1 more source

Circadian Immunity and Vascular Inflammation in Cardiovascular Disease Chronotherapy Windows: Time for a Re‐Assessment

Med Research, EarlyView.
ABSTRACT Circadian rhythms orchestrate cardiovascular physiology by regulating immune and inflammatory pathways. Disruption of these rhythms profoundly alters vascular homeostasis, thereby promoting the onset and progression of cardiovascular diseases (CVD).
Tian Zhang, Ge Zhang, Tian‐Ding Liu, Tianshu Gu, Fengyi Yu, Pengyuan Xu, Wunan Mi, Xuanjiang Zhao, Qian Guo, Honglin Zheng, Taiqi Zhao, Qiang Li, Di Lu, Mingxuan Duan, Chaoyang Yu, Ruhao Wu, Shiqian Zhang, Haonan Zhang, Zeyu Wang, Youyang Zheng, Yan Xiao, Zenglei Zhang, Ge Zhang   +22 more
wiley   +1 more source

An Sp1 Modulated Regulatory Region Unique to Higher Primates Regulates Human Androgen Receptor Promoter Activity in Prostate Cancer Cells [PDF]

, 2015
Funding: This work was supported by the Chief Scientist’s Office (CSO) of the Scottish Government (http://www.cso.scot.nhs.uk/): CWH (CZB-4-477) and IH (ETM/382).Peer reviewedPublisher ...
Hay, Colin W, Hunter, Irene, MacKenzie, Alasdair, McEwan, Iain J   +3 more
core   +7 more sources

Single-Cell Transcriptomics Reveals Zone-Specific Alterations of Liver Sinusoidal Endothelial Cells in CirrhosisSummary

Cellular and Molecular Gastroenterology and Hepatology, 2021
Background: Dysfunction of liver sinusoidal endothelial cells (LSECs) is permissive for the progression of liver fibrosis and cirrhosis and responsible for its clinical complications.
Tingting Su, Yilin Yang, Sanchuan Lai, Jain Jeong, Yirang Jung, Matthew McConnell, Teruo Utsumi, Yasuko Iwakiri   +7 more
doaj   +1 more source