Results 91 to 100 of about 882,731 (192)

Elevated CO2 and Temperature Alter Grass Pollen's Ability to Modify Transcriptome and Function of the Nasal Epithelium

Allergy, EarlyView.
We exposed human nasal epithelial tissues to pollen from grasses grown under different climate treatments (temperature and CO2). Pollen weakened epithelial tight junctions and altered cytokine‐related gene expression, with similar protein‐level effects.
Tarleena Tossavainen, Tanja Turunen, Maria‐Viola Martikainen, Miisa Kankaanpää, Marjo Malinen, Marjut Roponen   +5 more
wiley   +1 more source

The Role of KLF4 in Alzheimer’s Disease

Frontiers in Cellular Neuroscience, 2018
Krüppel-like factor 4 (KLF4), a member of the family of zinc-finger transcription factors, is widely expressed in range of tissues that play multiple functions.
Ziqian Cheng, Xiaohan Zou, Yang Jin, Shuohui Gao, Jiayin Lv, Bingjin Li, Ranji Cui   +6 more
doaj   +1 more source

Differential expression of Krüppel-like factor 4 and 5 in oral carcinomas and involvement in the epithelial-mesenchymal transition [PDF]

, 2014
日本歯科大学201
柴田 征紀
core  

Regulation of anti-apoptotic signaling by Kruppel-like factors 4 and 5 mediates lapatinib resistance in breast cancer

Cell Death and Disease, 2015
The Kruppel-like transcription factors (KLFs) 4 and 5 (KLF4/5) are coexpressed in mouse embryonic stem cells, where they function redundantly to maintain pluripotency.
Mark K. Farrugia, Sriganesh B. Sharma, Chen-Chung Lin, Sarah L. McLaughlin, D. Vanderbilt, A. Ammer, M. Salkeni, Peter Stoilov, Y. Agazie, Chad J. Creighton, Ruppert Jm   +10 more
semanticscholar   +1 more source

A genetic risk score based on BCL11A and HBS1L‐MYB variants predicts clinical severity in Brazilian sickle cell anaemia patients

British Journal of Haematology, EarlyView.
Summary Individuals with sickle cell anaemia (SCA) exhibit significant clinical heterogeneity influenced by several factors, especially fetal haemoglobin (HbF) levels. Variations in adult HbF levels are partly explained by the co‐inheritance of genetic variants that regulate globin expression.
Gabriela S. Arcanjo, Alexsandro P. Silva, Madi V. Diniz, Igor F. Domingos, Diego A. Pereira‐Martins, Amanda B. Araújo, Talita S. S. França, Ana C. Anjos, Aderson S. Araujo, Edis Belini‐Junior, Sara T. O. Saad, Fernando F. Costa, Antonio R. Lucena‐Araujo, Marcos André C. Bezerra   +13 more
wiley   +1 more source

Proteolysis at the extracellular matrix interface: Molecular architects and regulators in health and disease

The FEBS Journal, EarlyView.
The extracellular matrix (ECM) is a dynamic scaffold that orchestrates tissue architecture and cellular communication. A critical but underexplored interplay between proteases and cluster of differentiation molecules (CD) governs ECM turnover and directs cell fate.
David Jurnečka, Matija Hrovatin, Bor Bokalj, Boris Turk   +3 more
wiley   +1 more source

Is the Cis-Element CACCC-Box a Master Regulatory Element during Cardiovascular Disease? A Bioinformatics Approach from the Perspective of the Krüppel-like Family of Transcription Factors

Life
The CACCC-box motif emerges as a pivotal cis-regulatory element implicated in diverse developmental processes and diseases, particularly cardiovascular diseases (CVDs).
Juan Andrés García-Loredo, Michelle G. Santoyo-Suarez, Oscar Rodríguez-Nuñez, Diego Francisco Benitez Chao, Elsa N. Garza-Treviño, Patricio Adrián Zapata-Morin, Gerardo R. Padilla-Rivas, Jose Francisco Islas   +7 more
doaj   +1 more source

The Role of sptf-3 in C. elegans Growth and Development [PDF]

, 2011
The Sp family of transcription factors has important functions during development in animals. In the nematode Caenorhabditis elegans there are three Sp-related transcription factors (Sptf) which perform similarly important roles in development.
Ulm, Elizabeth
core  

Immune Evasion of Helicobacter pylori and Extra‐Gastric Cancer Risk

Journal of Gastroenterology and Hepatology, EarlyView.
ABSTRACT Helicobacter pylori (H. pylori) is a group 1 gastric carcinogen that plays a significant role in extra‐gastric digestive system cancers. H. pylori disrupts host cell homeostasis through expression of virulence factors leading to immune evasion as well as persistent gastric mucosal colonization. H. pylori infection has been shown to play a role
Evren Doruk Engin, Ayse Basak Engin, Atilla Engin   +2 more
wiley   +1 more source

KLF7 is a general inducer of human pluripotency

EMBO Reports
Pluripotency is the capacity to generate all somatic cells and the germ line and is governed by a self-reinforcing network of transcription factors.
Mattia Arboit, Irene Zorzan, Eleonora Pensabene, Marco Pellegrini, Federica Bertelli, Giorgia Panebianco, Davide Benvegnù, Giada Rossignoli, Paolo Martini, Gianluca Amadei, Elena Carbognin, Graziano Martello   +11 more
doaj   +1 more source