Results 101 to 110 of about 882,731 (192)

Circular RNAs: Unlocking new avenues in cardiometabolic disease management

The Journal of Physiology, EarlyView.
Abstract figure legend In the heart circular RNAs (circRNAs) function as microRNA sponges, interact with proteins and can even undergo translation. Advances in bioinformatics now enable their identification through high‐throughput RNA sequencing, whereas computational analyses reveal differential expression in cardiac disease settings.
Kimberley M. Mellor, Thomas D. Donelly, Gerald L.M. Naepi, Glenn D. Wadley, Bianca C. Bernardo   +4 more
wiley   +1 more source

Biomaterial Physical Cues as Gene Regulators for Cellular Agriculture

Advanced Genetics, Volume 7, Issue 2, June 2026.
This review elucidates how biomaterial physical cues—ranging from matrix stiffness to remote electromagnetic fields—serve as extrinsic regulators of gene expression in cellular agriculture. By identifying central mechanotransduction pathways that bridge physical inputs to genetic remodeling, the authors propose the “Material Genome” concept: a ...
Jianuo Liu, Ye Liu
wiley   +1 more source

Krüpple-like factors in cardiomyopathy: emerging player and therapeutic opportunities

Frontiers in Cardiovascular Medicine
Cardiomyopathy, a heterogeneous pathological condition characterized by changes in cardiac structure or function, represents a significant risk factor for the prevalence and mortality of cardiovascular disease (CVD). Research conducted over the years has
Le-Kun Gui, Le-Kun Gui, Huang-Jun Liu, Li-Jun Jin, Xiao-Chun Peng, Xiao-Chun Peng   +5 more
doaj   +1 more source

Systematic characterization of the zinc-finger-containing proteins in the mouse transcriptome [PDF]

, 2003
Zinc-finger-containing proteins can be classified into evolutionary and functionally divergent protein families that share one or more domains in which a zinc ion is tetrahedrally coordinated by cysteines and histidines.
Ravasi, Timothy, Huber, Thomas, Zavolan, Mihaela, Forrest, Alistair, Gaasterland, Terry, Grimmond, Sean, Group, RIKEN GER, Members, GSL, A. Hume, David   +8 more
core   +1 more source

Targeting EZH2 in Cancer: From Molecular Mechanisms to Clinical Translation

MedComm – Oncology, Volume 5, Issue 2, June 2026.
The abnormal overexpression or gain‐of‐function mutations of EZH2 play a significant role in cancer occurrence and progression, highlighting the importance and potential of EZH2 as a cancer biomarker. Therefore, screening for effective and safe small‐molecule inhibitors, degraders, and natural compounds targeting EZH2 through preclinical cancer models ...
Xi Zhong, Jieni Li, Mingxuan Pan, Xiaoxue Ke, Hongjuan Cui   +4 more
wiley   +1 more source

Extracellular signal-regulated kinase 5 promotes acute cellular and systemic inflammation. [PDF]

, 2015
Inflammatory critical illness is a syndrome that is characterized by acute inflammation and organ injury, and it is triggered by infections and noninfectious tissue injury, both of which activate innate immune receptors and pathways.
Farrar, Katherine, Gray, Nathanael S, Hellman, Judith, Khakpour, Samira, Prakash, Arun, Sundar, Shirin, Tran, Alphonso, Wang, Jinhua, Wilhelmsen, Kevin, Xu, Fengyun   +9 more
core   +1 more source

Gastrointestinal strictures in a pediatric patient with Satoyoshi syndrome

JPGN Reports, Volume 7, Issue 2, Page 247-251, May 2026.
Abstract We present a novel case of gastrointestinal strictures in a young girl with Satoyoshi syndrome (SS), highlighting multi‐system features of alopecia universalis, painful muscle cramps with dystonia, aberrant growth velocity, and skeletal abnormalities.
Katherine (Tusia) Pohoreski, Gary Galante, Kiera Pajunen, Marie‐Anne Brundler, Samarjeet Bhandal, Iwona Wrobel   +5 more
wiley   +1 more source

Krüppel-like transcription factors KLF1 and KLF2 have unique and coordinate roles in regulating embryonic erythroid precursor maturation

Haematologica, 2014
The Krüppel-like transcription factors KLF1 and KLF2 are essential for embryonic erythropoiesis. They can partially compensate for each other during mouse development, and coordinately regulate numerous erythroid genes, including the β-like globins ...
Divya S. Vinjamur, Kristen J. Wade, Safa F. Mohamad, Jack L. Haar, Stephen T. Sawyer, Joyce A. Lloyd   +5 more
doaj   +1 more source

Untersuchungen zur Rolle des Transkriptionsfaktors "Krueppel-like factor 4" in der Sertoli-Zelle der Maus [PDF]

, 2006
Der Zinkfinger-Transkriptionsfaktor "Krueppel-like factor 4" (Klf4) wird in Epithelzellen vieler Gewebe, wie z.B. des Darms, des Magens und der Haut stark exprimiert.
Godmann, Maren, Renkawitz-Pohl, Renate (Prof. Dr.)   +1 more
core   +1 more source

Age‐Dependent Alterations of Chromosomal Passenger Complex Members During Implantation and Decidualization in the Mouse Uterus

Aging Cell, Volume 25, Issue 5, May 2026.
Aging in females reduces the number of implantation sites and leads to specific, compartment‐dependent changes in components of the chromosomal passenger complex (pIncenp, Aurora B, Survivin, Borealin) during mouse uterine implantation and decidualization.
Ezgi Golal, Cemre Nur Balci, Nuray Acar
wiley   +1 more source