Results 11 to 20 of about 130,425 (315)
Detection of activating mutations in RAS/RAF/MEK/ERK and JAK/STAT signaling pathways [PDF]
Терапевтический архив, 2020 Issue.The study of activating mutations (NRAS,KRAS,FLT3,JAK2,CRLF2genes) of RAS/RAF/MEK/ERK and JAK/STAT signaling pathways in B-cell acute lymphoblastic leukemia (B-ALL) in adult patients which are included in Russian multicenter clinical trials ...
K. I. Zarubina +13 more
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KRAS Mouse Models: Modeling Cancer Harboring KRAS Mutations [PDF]
Genes & Cancer, 2011 KRAS is a potent oncogene and is mutated in about 30% of all human cancers. However, the biological context of KRAS-dependent oncogenesis is poorly understood. Genetically engineered mouse models of cancer provide invaluable tools to study the oncogenic process, and insights from KRAS-driven models have significantly increased our understanding of the ...
Rónán C, O'Hagan, Joerg, Heyer
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Research Progress of Proteolysis Targeting Chimeria in NSCLC Therapy
Chinese Journal of Lung Cancer, 2022 Proteolysis targeting chimeria (PROTAC) degrades target proteins by utilizing the ubiquitin-proteasome pathway, subverting the concept of traditional small molecule inhibitors.
Lin JIANG +4 more
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Molecular genetic testing in colon cancer: clinical aspects
Alʹmanah Kliničeskoj Mediciny, 2022 Molecular genetic diagnostics is an essential element to plan for management of colorectal cancer (CRC) patients. The choice of systemic treatment for CRC is impossible without molecular testing of the tumor.
Aleksandr S. Martianov +3 more
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Acta Historica Universitatis Klaipedensis, 2014 The article examines the role of the last Jagiellonian monarchs, Sigismund I (1506-1548) and his son Sigismund II Augustus (1548-1572), in promoting and securing religious peace in the multi-confessional society of the 16th-century Rzeczpospolita.
Paweł Kras
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The prevalence of KRAS and BRAF mutation in colorectal cancer patients in Bali
Indonesian Journal of Biotechnology, 2022 Mutations in the KRAS (Kirsten rat sarcoma viral oncogene homolog gene) and BRAF (v‐Raf murine sarcoma viral oncogene homolog B1) gene play a significant role in primary resistance to colorectal cancer therapy.
Ayu Dewi Ni Nyoman +4 more
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Small Molecule KRAS Agonist for Mutant KRAS Cancer Therapy [PDF]
Molecular Cancer, 2019 Lung cancer patients with KRAS mutation(s) have a poor prognosis due in part to the development of resistance to currently available therapeutic interventions. Development of a new class of anticancer agents that directly targets KRAS may provide a more attractive option for the treatment of KRAS-mutant lung cancer.Here we identified a small molecule ...
Ke Xu +8 more
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Katalog husytów i osób podejrzewanych o husytyzm w piętnastowiecznej Polsce
Archiwa, Biblioteki i Muzea Kościelne, 2000 -
Paweł Kras
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Nesting of Eurasian Crag Martin (Ptyonoprogne rupestris) in the Malá Fatra Mts. in Slovakia
Tichodroma, 2022 We detected occurrence and nesting of Eurasian Craig Martin (Ptyonoprogne rupestris) for the first time in Slovakia. One nesting pair with four juveniles was detected during the 2022 nesting season in the Malá Fatra mountains.
Štefan Matis +2 more
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Targeting ST2 expressing activated regulatory T cells in Kras-mutant lung cancer
OncoImmunology, 2020 Oncogenic KRAS-mutant lung cancers remain treatment refractory. A better understanding of the immune response of KRAS-mutant lung cancers is required to facilitate the development of potential therapeutic strategies.
Byung-Seok Kim +3 more
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