Results 211 to 220 of about 260,030 (390)
Versatile Palladium‐Catalyzed C‐H Arylation of Fluoroarenes with 2‐Chloropyridine Derivatives
Chemistry – A European Journal, EarlyView.Direct C─H arylation of fluoroarenes with 2‐chloropyridines is enabled by a simple Pd/SPhos system in isopropyl acetate. The method uses inexpensive reactants and shows broad scope and high yields. DFT computations explain reactivity and selectivity.
Federico Belnome +6 more
wiley +1 more source
FLAG assay as a novel method for real-time signal generation during PCR: application to detection and genotyping of KRAS codon 12 mutations [PDF]
, 2007 Giulia Amicarelli +3 more
openalex +1 more source
Clinical Pharmacology &Therapeutics, EarlyView.Several regulatory initiatives have been made to clarify the acceptability and requirements of real‐world data and real‐world evidence (RWD/E) for the benefit/risk assessment of new medical products in Japan. The objectives of this review were to characterize the use of RWD/E in regulatory applications of new medical products and to describe the ...
Suguru Okami +2 more
wiley +1 more source
Mutations of BRAF and KRAS Precede the Development of Ovarian Serous Borderline Tumors
, 2004 Chung‐Liang Ho +4 more
openalex +1 more source
Biochemical and Functional Characterization of Germ Line KRAS Mutations [PDF]
, 2007 Suzanne Schubbert +8 more
openalex +1 more source
Environmental and Molecular Mutagenesis, EarlyView.Abstract Exposure levels without appreciable human health risk may be determined by dividing a point of departure on a dose–response curve (e.g., benchmark dose) by a composite adjustment factor (AF). An “effect severity” AF (ESAF) is employed in some regulatory contexts.
Barbara L. Parsons +17 more
wiley +1 more source
Highly Conserved Sequence of Exon 15 BRAF Gene and KRAS Codon 12 Mutation among Greek Patients with Colorectal Cancer [PDF]
, 2007 Emmanouil K. Symvoulakis +6 more
openalex +1 more source