Results 241 to 250 of about 130,425 (315)

Supplementary Table S2 from Effects of <i>KRAS</i> Genetic Interactions on Outcomes in Cancers of the Lung, Pancreas, and Colorectum

Isabella N. Grabski, John V. Heymach, Kenneth L. Kehl, Scott Kopetz, Ken S. Lau, Gregory J. Riely, Deborah Schrag, Rona Yaeger, Rafael A. Irizarry, Kevin M. Haigis   +9 more
openalex   +1 more source

Disarming the Hsp70–Bim Alliance: Small‐Molecule and Peptidic Disruptors of a Chaperone‐Apoptotic Switch in Cancer

ChemistryOpen, EarlyView.
Targeting a nucleotide‐sensitive groove on Hsp70 that binds the Bim BH3 helix, we integrate structures, biophysics, and SAR from peptides, fragments, and phenalene‐dicarbonitrile “wedges.” These disrupt the Hsp70–Bim complex with sub‐µM cellular engagement and in vivo activity while sparing Hsp90/mortalin.
Emadeldin M. Kamel, Mohammed Al‐zharani, Lina M. Alneghery, Noha A. Ahmed, Faris F. Aba Alkhayl, Al Mokhtar Lamsabhi   +5 more
wiley   +1 more source

Schimmelpenning-Feuerstein-Mims syndrome: a systematic review of clinical cases to identify genotype-phenotype associations. [PDF]

Front Med (Lausanne)
Zelenova E, Belysheva T, Sharapova E, Semenova V, Valiev T, Nasedkina T.   +5 more
europepmc   +1 more source

Supplemental Table S1 from D3S-001, a KRAS G12C Inhibitor with Rapid Target Engagement Kinetics, Overcomes Nucleotide Cycling, and Demonstrates Robust Preclinical and Clinical Activities

Jing Zhang, Sun Min Lim, Mi Ra Yu, Cheng Chen, Jia Wang, Wenqian Wang, Haopeng Rui, Jingtao Lu, Shun Lü, Tony Mok, Zhi Jian Chen, Byoung Chul Cho   +11 more
openalex   +1 more source

Metamorphoses in pancreatic cancer precursors: the role of simple mucinous cysts†

The Journal of Pathology, EarlyView.
Abstract Pancreatic cystic lesions present a unique opportunity to identify and potentially prevent pancreatic ductal adenocarcinoma (PDAC), one of the deadliest solid tumors. Until now, research has primarily focused on intraductal papillary mucinous neoplasms (IPMNs) and mucinous cystic neoplasms (MCNs), whose potential for malignant transformation ...
Paolo Riccardo Camisa, Daniele Campa, Irene Esposito, Stefano Crippa   +3 more
wiley   +1 more source

Impact of KRAS G12C mutation on the efficacy of chemoradiotherapy in patients with unresectable stage II or III non-small cell lung cancer. [PDF]

Front Oncol
Cabon J, Lerouge D, Thureau S, Balosso J, Guigo M, Gervais R, Dubos C, Dô P, Demontrond P, Curcio H, Deshayes S, Madelaine J, Leite Ferreira D, Jacson L, Lecrosnier K, Chevalier F, Guisier F, Dantoing E, Leconte A, Christy F, Césaire M.   +20 more
europepmc   +1 more source

Retraction notice to “Porphyrins to restrict progression of pancreatic cancer by stabilizing KRAS G-quadruplex: In silico, in vitro and in vivo validation of anticancer strategy” [European Journal of Pharmaceutical Sciences 125 (2018) Pages 39-53]

Rudradip Pattanayak, Atish Barua, Amlan Das, Tanima Chatterjee, Adrija Pathak, Pritha Choudhury, Srikanta Sen, Prosenjit Saha, Maitree Bhattacharyya   +8 more
openalex   +1 more source

Fatal Pembrolizumab‐Induced Stevens‐Johnson Syndrome/Toxic Epidermal Necrolysis in a Patient With Advanced Lung Adenocarcinoma

The Kaohsiung Journal of Medical Sciences, EarlyView.
Po‐Chih Chang, Ting‐Wei Chang, Chia‐Yu Kuo, Yi‐Zhe Wu   +3 more
wiley   +1 more source

Integrating artificial intelligence (AI) into colorectal cancer reporting

The Journal of Pathology, EarlyView.
Abstract Artificial intelligence (AI) and deep learning (DL) are transforming cancer research and clinical care, with histopathology playing a central role in this transformation. In colorectal cancer (CRC), the second leading cause of cancer mortality world‐wide, multimodal and vision‐language models (VLMs) hold particular promise for enhancing the ...
Konstantin Bräutigam, Ann‐Marie Baker, Viktor H Koelzer, Jakob N Kather, Trevor A Graham   +4 more
wiley   +1 more source

KRAS Codon-Specific Mutations Differentially Toggle PI3K Pathway Signaling and Alter Sensitivity to Inavolisib (GDC-0077). [PDF]

Mol Cancer Ther
Song KW, Ong CC, Lin E, Lau J, Sodir NM, Jin DX, Hutchinson KE, Xie S, Tan J, Liang Y, Modrusan Z, Martin SE, Maddalo D, Hafner M, Dey A.   +14 more
europepmc   +1 more source