Results 241 to 250 of about 260,030 (390)

STK11/LKB1 Mutations and PD-1 Inhibitor Resistance in KRAS-Mutant Lung Adenocarcinoma.

Cancer Discovery, 2018
F. Skoulidis, M. Goldberg, D. Greenawalt, M. Hellmann, M. Awad, J. Gainor, A. Schrock, R. Hartmaier, S. Trabucco, L. Gay, Siraj M. Ali, J. Elvin, G. Singal, J. Ross, D. Fabrizio, P. Szabo, Han Chang, A. Sasson, S. Srinivasan, S. Kirov, J. Szustakowski, P. Vitazka, R. Edwards, J. Bufill, N. Sharma, S. Ou, N. Peled, D. Spigel, H. Rizvi, E. J. Aguilar, B. Carter, J. Erasmus, D. Halpenny, A. Plodkowski, N. Long, M. Nishino, W. Denning, Ana Galán-Cobo, Haifa Hamdi, Taghreed Hirz, P. Tong, Jing Wang, J. Rodriguez-Canales, P. Villalobos, E. Parra, N. Kalhor, L. Sholl, J. Sauter, A. Jungbluth, M. Mino‐Kenudson, Roxana Azimi, Y. Elamin, Jianjun Zhang, G. Leonardi, F. Jiang, Kwok-kin Wong, J. Lee, V. Papadimitrakopoulou, I. Wistuba, V. Miller, G. Frampton, J. Wolchok, A. Shaw, P. Jänne, P. Stephens, C. Rudin, W. Geese, L. Albacker, J. Heymach   +68 more
semanticscholar   +1 more source

Single‐cell multi‐omics characterize colorectal tumors, adjacent healthy tissue and matched (tumor) organoids identifying CRC‐unique features

International Journal of Cancer, EarlyView.
What's New? Patient‐derived organoids provide a promising platform for modeling colorectal cancer. The authors demonstrated that organoids derived from normal colorectal tissue recapitulate the cellular composition and differentiation trajectory of colorectal crypts.
Zhijun Yu, Merel Derksen, Brigit M. te Pas, Sabrina Ladstätter, Rene Overmeer, Peter Brazda, Marc van de Wetering, Farzin Pourfarzad, Robert G. J. Vries, Wout Megchelenbrink, Christoph Bock, Lucia Altucci, Hendrik G. Stunnenberg   +12 more
wiley   +1 more source

Evolution of direct RAS inhibitors: from undruggable target to clinical breakthroughs. [PDF]

Mol Cancer
Wang X, Wu J, Xiao A, Wang J, Tian J.
europepmc   +1 more source

Oncogene cooperation in tumor maintenance and tumor recurrence in mouse mammary tumors induced by Myc and mutant Kras [PDF]

, 2008
Katrina Podsypanina, Katerina Politi, Levi J. Beverly, Harold Varmus   +3 more
openalex   +1 more source

Pre‐ and post‐diagnostic meat intake in relation to risk of recurrence and mortality among individuals with stage I–III colorectal cancer

International Journal of Cancer, EarlyView.
What's New? Processed meat and unprocessed red meat intakes are associated with increased colorectal cancer risk. However, evidence on their associations with mortality after colorectal cancer diagnosis is inconsistent. This study examined associations between three meat types, including unprocessed poultry, and the risk of recurrence and all‐cause ...
Anne‐Sophie van Lanen, Dieuwertje E. Kok, Evertine Wesselink, Jeroen W. G. Derksen, Anne M. May, Karel C. Smit, Miriam Koopman, Johannes H. W. de Wilt, Ellen Kampman, Fränzel J. B. van Duijnhoven, on behalf of the COLON and PLCRC studies, Hester van Cruijsen, Jan Willem T. Dekker, Henk K. van Halteren, Johan J.B. Janssen, Maartje Los, Anandi H. W. Schiphorst, Dirkje W. Sommeijer, Dirk J. A. Sonneveld, Mark P. S. Sie, Maarten Vermaas   +20 more
wiley   +1 more source

Functional Analysis of Rare RAS Variants of Unknown Significance. [PDF]

Cancer Res Commun
Park S, Ikegami M, Kitada R, Takamochi K, Suzuki K, Mano H, Kohsaka S.   +6 more
europepmc   +1 more source

KRAS wild-type state predicts survival and is associated to early radiological response in metastatic colorectal cancer treated with cetuximab

, 2007
Wendy De Roock, Hubert Piessevaux, Joris De Schutter, M. Janssens, Gert De Hertogh, Nicola Personeni, Bart Biesmans, Jean‐Luc Van Laethem, Marc Peeters, Yves Humblet, Eric Van Cutsem, Sabine Tejpar   +11 more
openalex   +1 more source

PTPN11, SOS1, KRAS, and RAF1 gene analysis, and genotype–phenotype correlation in Korean patients with Noonan syndrome [PDF]

, 2008
Jung Min Ko, Jae‐Min Kim, Gu-Hwan Kim, Han‐Wook Yoo   +3 more
openalex   +1 more source

A phase 1 dose-escalation and expansion study of binimetinib (MEK162), a potent and selective oral MEK1/2 inhibitor [PDF]

, 2017
et al,, Tan, Benjamin R
core   +2 more sources

Genetic differences between primary colorectal cancer and its paired synchronous and metachronous metastases

International Journal of Cancer, EarlyView.
What's New? Colorectal cancer (CRC) frequently metastasizes to the liver, either synchronously with primary diagnosis or metachronously, after variable time intervals. Although implicated, the role of genetic factors in driving synchronous and metachronous disease progression remains uncertain.
Marie Rajtmajerova, Filip Ambrozkiewicz, Viktor Hlavac, Andriy Trailin, Lenka Cervenkova, Jan Bruha, Simona Susova, Pavel Soucek, Pavel Vodicka, Ludmila Vodickova, Ondrej Kubecek, Stanislav Filip, Venkata R. Mallela, Wenjing Ye, Frantisek Zitricky, Vaclav Liska, Kari Hemminki   +16 more
wiley   +1 more source