Significance of KRAS/PAK1/Crk pathway in non-small cell lung cancer oncogenesis. [PDF]
, 2015 BackgroundKey effector(s) of mutated KRAS in lung cancer progression and metastasis are unknown. Here we investigated the role of PAK1/Crk axis in transduction of the oncogenic KRAS signal in non-small cell lung cancer (NSCLC).MethodsWe used NSCLC ...
Aljilani, Amir +7 more
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Zhongguo cuzhong zazhi, 2022 目的 探究散发性脑动静脉畸形组织中Kirsten大鼠肉瘤病毒癌基因同源物（Kirsten rat sarcoma viral oncogene homolog，KRAS）突变与临床特征之间的关系。 方法 回顾性收集散发性动静脉畸形（brain arteriovenous malformation，BAVM）术后病变组织的福尔马林固定石蜡包埋（formali n-fixation and paraffin-embedding，FFPE）样本和对应患者的临床信息，从FFPE样本中提取DNA ...
李昊, 许宏远, 押小龙, 曹勇
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Small Molecule KRAS Agonist for Mutant KRAS Cancer Therapy [PDF]
Molecular Cancer, 2019 Lung cancer patients with KRAS mutation(s) have a poor prognosis due in part to the development of resistance to currently available therapeutic interventions. Development of a new class of anticancer agents that directly targets KRAS may provide a more attractive option for the treatment of KRAS-mutant lung cancer.Here we identified a small molecule ...
Jun Zhang +8 more
openaire +4 more sources
Correction to: Small Molecule KRAS Agonist for Mutant KRAS Cancer Therapy [PDF]
Molecular Cancer, 2020 An amendment to this paper has been published and can be accessed via the original article.
Suresh S. Ramalingam +8 more
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Impact of the Specific Mutation in KRAS Codon 12 Mutated Tumors on Treatment Efficacy in Patients with Metastatic Colorectal Cancer Receiving Cetuximab-Based First-Line Therapy: A Pooled Analysis of Three Trials [PDF]
, 2012 Purpose: This study investigated the impact of specific mutations in codon 12 of the Kirsten-ras (KRAS) gene on treatment efficacy in patients with metastatic colorectal cancer (mCRC).
Allegra CJ +41 more
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High-Resolution Three-Dimensional NMR Structure Of The KRAS Proto-Oncogene Promoter Reveals Key Features Of A G-Quadruplex Involved In Transcriptional Regulation [PDF]
, 2017 Non-canonical base pairing within guanine-rich DNA and RNA sequences can produce G-quartets, whose stacking leads to the formation of a G-quadruplex (G4).
Ivashchenko, S. +5 more
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Acta Historica Universitatis Klaipedensis, 2014 The article examines the role of the last Jagiellonian monarchs, Sigismund I (1506-1548) and his son Sigismund II Augustus (1548-1572), in promoting and securing religious peace in the multi-confessional society of the 16th-century Rzeczpospolita.
Paweł Kras
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RelA regulates CXCL1/CXCR2-dependent oncogene-induced senescence in murine Kras-driven pancreatic carcinogenesis [PDF]
, 2016 Tumor suppression that is mediated by oncogene-induced senescence (OIS) is considered to function as a safeguard during development of pancreatic ductal adenocarcinoma (PDAC). However, the mechanisms that regulate OIS in PDAC are poorly understood. Here,
Algül, Hana +17 more
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Katalog husytów i osób podejrzewanych o husytyzm w piętnastowiecznej Polsce
Archiwa, Biblioteki i Muzea Kościelne, 2000 -
Paweł Kras
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Nesting of Eurasian Crag Martin (Ptyonoprogne rupestris) in the Malá Fatra Mts. in Slovakia
Tichodroma, 2022 We detected occurrence and nesting of Eurasian Craig Martin (Ptyonoprogne rupestris) for the first time in Slovakia. One nesting pair with four juveniles was detected during the 2022 nesting season in the Malá Fatra mountains.
Štefan Matis +2 more
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