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Krebs and his trinity of cycles
Nature Reviews Molecular Cell Biology, 2000Everyone who has ever taken biology at school has heard of the Krebs cycle, but few realize that Hans Krebs also discovered two other cycles. It is appropriate, at the centenary of his birth, to consider the circumstances and experiments that led Krebs to establish these metabolic pathways.
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2014
This chapter focuses on two classic Krebs cycle disorders (2-oxoglutaric aciduria and fumarase deficiency) and two recently discovered disorders of the Krebs cycle, severely affecting mitochondrial function and mitochondrial maintenance (succinyl-CoA synthetase –SCS – deficiencies, characterized by mutations in SUCLA2 and SUCLG1 genes).
Eva Morava, Rosalba Carrozzo
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This chapter focuses on two classic Krebs cycle disorders (2-oxoglutaric aciduria and fumarase deficiency) and two recently discovered disorders of the Krebs cycle, severely affecting mitochondrial function and mitochondrial maintenance (succinyl-CoA synthetase –SCS – deficiencies, characterized by mutations in SUCLA2 and SUCLG1 genes).
Eva Morava, Rosalba Carrozzo
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Role of the Krebs Cycle in Ethylene Biosynthesis
Nature, 1962SEVERAL reports have appeared in the literature recently on ethylene biosynthesis in fruit and in the mould, Penicillium digitatum. With apple tissue, Burg and Thimann1 concluded, from the findings of isotope experiments, that ethylene is derived from sugar via pathways unrelated to glycolysis, the Krebs cycle, the pentose phosphate pathway or the ...
C H, WANG, A, PERSYN, J, KRACKOV
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Journal of Biological Education, 1983
This paper outlines a simple but rigorous treatment of the Krebs Cycle suitable for A-level Biology students. The importance of the addition of water molecules in various stages of the cycle is stressed as well as the removal of hydrogen atoms by the oxidizing enzymes.
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This paper outlines a simple but rigorous treatment of the Krebs Cycle suitable for A-level Biology students. The importance of the addition of water molecules in various stages of the cycle is stressed as well as the removal of hydrogen atoms by the oxidizing enzymes.
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Defects of Pyruvate Metabolism and the Krebs Cycle
Journal of Child Neurology, 2002Seizures and metabolic disease are frequently associated, either indirectly as a consequence of the metabolically caused brain dysgenesis or directly by the metabolic derangement. This article describes defects in pyruvate metabolism (pyruvate carboxylase deficiency, pyruvate dehydrogenase deficiency) and Krebs cycle defects such as fumarase ...
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Modelling the Krebs cycle and oxidative phosphorylation
Journal of Biomolecular Structure and Dynamics, 2013The Krebs cycle and oxidative phosphorylation are the two most important sets of reactions in a eukaryotic cell that meet the major part of the total energy demands of a cell. In this paper, we present a computer simulation of the coupled reactions using open source tools for simulation.
Kalyani, Korla, Chanchal K, Mitra
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A reverse KREBS cycle in photosynthesis: consensus at last
Photosynthesis Research, 1990The Krebs cycle (citric acid or tricarboxylic acid cycle), the final common pathway in aerobic metabolism for the oxidation of carbohydrates, fatty acids and amino acids, is known to be irreversible. It liberates CO2 and generates NADH whose aerobic oxidation yields ATP but it does not operate in reverse as a biosynthetic pathway for CO2 assimilation.
B B, Buchanan, D I, Arnon
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Journal of Chemical Education, 2001
This puzzle embeds 46 names, terms, abbreviations, and acronyms about the citric acid (Krebs) cycle in a 14- x 17-letter matrix. A descriptive narrative beside it describes important features of the pathway. All the terms a student needs to find are embedded there with the first letter followed by underlined blanks to be completed.
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This puzzle embeds 46 names, terms, abbreviations, and acronyms about the citric acid (Krebs) cycle in a 14- x 17-letter matrix. A descriptive narrative beside it describes important features of the pathway. All the terms a student needs to find are embedded there with the first letter followed by underlined blanks to be completed.
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Truncation of the Krebs Cycle During Hypoglycemic Coma
Medicinal Chemistry, 2008There is a misconception that hypoglycemic nerve cell death occurs easily, and can happen in the absence of coma. In fact, coma is the prerequisite for neuronal death, which occurs via metabolic excitatory amino acid release. The focus on nerve cell death does not explain how most brain neurons and all glia survive. Brain metabolism was interrogated in
Garnette R, Sutherland +2 more
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Organization of Krebs tricarboxylic acid cycle enzymes
Biochemical Medicine, 1985Binding of enzymes of the Krebs TCA cycle to biological membranes was characterized with respect to intracellular location, susceptibility to various chemical and physical treatments, and extractability as a macromolecular component of the mitochondrial inner membrane.
J B, Robinson, P A, Srere
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