Results 261 to 270 of about 3,153,249 (347)

Mild Short‐Term Caloric Restriction Induces Coordinated Changes That Promote Lipid Deposition While Maintaining Thermogenesis Capacity in Interscapular Brown Adipose Tissue of Male Rats

The FASEB Journal, Volume 40, Issue 3, 15 February 2026.
Rats under mild caloric restriction (85% vs. ad libitum) for 2 weeks show metabolic and structural adaptations in iBAT. Caloric restriction increases glycolysis and triglyceride deposition in the tissue, leading to larger lipid droplets. It also reduces mitochondrial iBAT content, while maintaining iBAT thermogenic potential thanks to an increased ...
Giuliana Panico, Vincenzo Migliaccio, Gabriella Pinto, Anna Iliano, Gianluca Fasciolo, Martina Coletta, Paola Venditti, Maria Moreno, Angela Amoresano, Pieter de Lange, Lillà Lionetti, Assunta Lombardi   +11 more
wiley   +1 more source

Krebs cycle derivatives, dimethyl fumarate and itaconate, control metabolic reprogramming in inflammatory human microglia cell line

Moris Sangineto, Martina Ciarnelli, Archana Moola, Vidyasagar Naik Bukke, Tommaso Cassano, Rosanna Villani, Antonino Davide Romano, Giuseppe Di Gioia, Carlo Avolio, Gaetano Serviddio   +9 more
openalex   +1 more source

Self‐Driving Development of Perfusion Processes for Monoclonal Antibody Production

Biotechnology and Bioengineering, Volume 123, Issue 2, Page 391-405, February 2026.
ABSTRACT The development of autonomous agents in bioprocess development is crucial for advancing biopharma innovation. Time and resources required to develop and transfer a process for clinical material generation can be significantly decreased. While robotics and machine learning have greatly accelerated drug discovery and initial screening, the later
Chethana Janardhana Gadiyar, Claudio Müller, Thomas Vuillemin, Jean‐Marc Bielser, Jonathan Souquet, Alessandro Fagnani, Michael Sokolov, Moritz von Stosch, Fabian Feidl, Alessandro Butté, Mariano Nicolas Cruz Bournazou   +10 more
wiley   +1 more source

Untargeted Metabolomics Reveals Seasonal and Tissue‐Specific Metabolic Shifts in Holothuria cinerascens

Chemistry &Biodiversity, Volume 23, Issue 2, February 2026.
Untargeted metabolic profiling of three body tissues from Holothuria cinerascens in South Africa using 1H‐NMR and UPLC–QTOF–MS revealed distinct tissue‐specific and seasonal metabolic variations, with the body wall and gut/mesentery exhibiting high metabolite diversity.
Cassandra Upton, Gerhard Prinsloo, Paul Steenkamp, Moses Okpeku   +3 more
wiley   +1 more source

Diet Switching and Interspecific Competition in Sympatric Steppe Ungulates Under Seasonal Resource Variability

Ecology and Evolution, Volume 16, Issue 2, February 2026.
ABSTRACT Understanding the mechanisms of competition and coexistence among sympatric species is crucial for deepening our understanding of interspecific interactions and informing the conservation of rare and endangered wildlife. In this study, we utilized DNA macro‐barcoding technology to analyze the seasonal dietary habits of Kiang (Equus kiang) and ...
Huiqin Dong, Bin Feng, Shuai Yang, Yuna Jia, Mingsen Qin, Wenke Bai   +5 more
wiley   +1 more source

Alpha‐Lipoic Acid Reduces NLRP3/ASC Expression and IL‐1β Release in Kupffer Cells and Improves Insulin Signaling in FL83B Hepatocytes Exposed to a Conditioned Medium

Food Science &Nutrition, Volume 14, Issue 2, February 2026.
Alpha‐lipoic acid (ALA) reduced NLRP3/ASC expression, attenuated upstream NF‐κB/ERK signaling, and decreased IL‐1β release while preserving mitochondrial membrane potential in murine Kupffer cells subjected to LPS priming and a second signal. Conditioned medium from ALA‐pretreated Kupffer cells (particularly 100 μM) enhanced glucose uptake and improved
Chih‐Yuan Ko, Yangming Martin Lo, Thi Kim Ngan Nguyen, Shao‐Ting Kao, Chung‐Hsin Wu, Wen‐Chung Huang, Szu‐Chuan Shen   +6 more
wiley   +1 more source

Targeting aerobic glycolysis combats tyrosine kinase inhibitor resistance of hepatocellular carcinoma

International Journal of Cancer, Volume 158, Issue 3, Page 475-487, 1 February 2026.
Abstract Hepatocellular carcinoma (HCC) represents the predominant form of primary liver cancer and is frequently identified at a late stage, necessitating systemic therapy. However, resistance to first‐line tyrosine kinase inhibitor therapies, such as sorafenib and lenvatinib, remains a significant clinical challenge.
Longtao Zhao, Junjie Cheng, Yiming Zheng, Jing Wu, Jia Fan, Haixiang Sun, Chao Gao   +6 more
wiley   +1 more source

Intestinal Obstruction [PDF]

, 2000
Winslet, MC
core  

Mitochondrial Transporter ABCB10 Protects Against Doxorubicin‐Induced Respiratory Muscle Dysfunction Independent of Changes to Diaphragm Accumulation

Journal of Cachexia, Sarcopenia and Muscle, Volume 17, Issue 1, February 2026.
ABSTRACT Background Doxorubicin (DOX) is a highly effective chemotherapeutic agent whose use can cause respiratory toxicity, increasing patient fatigue and negatively impacting quality of life and survival. These adverse effects occur due to diaphragm muscle mitochondrial accumulation of DOX, where it causes reactive oxygen species production and iron ...
Ashley J. Smuder, Vivian Doerr, Cesar E. Jacintho Moritz, Jie Li, Branden L. Nguyen   +4 more
wiley   +1 more source

Rheumatoid Arthritis Preceded by Interstitial Lung Disease Controlled by Long‐Term Treatment With the Janus Kinase 1‐Selective Inhibitor, Filgotinib: A Case Report

Respirology Case Reports, Volume 14, Issue 2, February 2026.
We present a case of ILD preceding RA onset. The disease activity of arthritis and ILD was controlled, and ILD was stabilised for 4 years with the JAK1 selective inhibitor, filgotinib. ABSTRACT We present a case of active interstitial lung disease (ILD) preceding the onset of rheumatoid arthritis (RA).
Takeo Sato, Shoko Nakazawa, Shotaro Yamamoto, Katsuya Nagatani, Kojiro Sato   +4 more
wiley   +1 more source