Results 11 to 20 of about 2,366 (190)
MicroRNA-1185 Induces Endothelial Cell Apoptosis by Targeting UVRAG and KRIT1 [PDF]
Cellular Physiology and Biochemistry, 2017 Background/Aims: Atherosclerosis is a multifactorial chronic disease and is the main cause of death and impairment in the world. Endothelial injury and apoptosis play a crucial role in the onset and development of atherosclerosis. MicroRNAs (miRNAs) have
Haoyuan Deng +9 more
doaj +3 more sources
Correction: KRIT1 Regulates the Homeostasis of Intracellular Reactive Oxygen Species.
PLoS ONE, 2019 [This corrects the article DOI: 10.1371/journal.pone.0011786.].
PLOS ONE staff
doaj +3 more sources
GERM-LINE/SOMATIC DNA COMPARISON IN SPORADIC PATIENTS WITH CEREBRAL CAVERNOUS MALFORMATIONS.
Euromediterranean Biomedical Journal, 2017 Cerebral cavernous malformations (CCMs) are benign tumours that affect brain capillaries. Although many cases remain asymptomatic, their incidence is steadily increasing.
Ivan Anchesi
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KRIT1 loss of function causes a ROS-dependent upregulation of c-Jun [PDF]
Free Radical Biology and Medicine, 2014 Loss-of-function mutations in the KRIT1 gene (CCM1) have been associated with the pathogenesis of cerebral cavernous malformations (CCM), a major cerebrovascular disease.
Biasi, Fiorella +9 more
core +5 more sources
Familial Cerebral Cavernous Malformations: Pathophysiology, Genetics, Biomarkers, and Treatment Perspectives. [PDF]
J NeurochemCerebral cavernous malformations (CCMs) are vascular lesions in the brain caused by inherited genetic mutations in the CCM1/2/3 genes that disrupt normal blood vessel function. This work demonstrates that these mutations lead to endothelial dysfunction, inflammation, and iron accumulation, which can be detected by magnetic resonance imaging (MRI) and ...
Fontes-Dantas FL +5 more
europepmc +2 more sources
KRIT1 in vascular biology and beyond. [PDF]
Biosci RepAbstract KRIT1 is a 75 kDa scaffolding protein which regulates endothelial cell phenotype by limiting the response to inflammatory stimuli and maintaining a quiescent and stable endothelial barrier. Loss-of-function mutations in KRIT1 lead to the development of cerebral cavernous malformations (CCM), a disease marked by the formation ...
Glading AJ.
europepmc +3 more sources
Cerebral Cavernous Malformation: From Genetics to Pharmacotherapy. [PDF]
Brain BehavCCM1, CCM2, CCM3, MAP3K3, and PIK3CA genes mediate CCM pathogenesis by regulating the RhoA–ROCK, MAP3K3–KLF2/4, and PIK3CA–AKT–mTOR pathways, affecting processes such as cell migration, intercellular junctions, cell proliferation, inflammation, autophagy, EndMT, angiogenesis, and oxidative stress.
Zhang Z, Deng J, Sun W, Wang Z.
europepmc +2 more sources
Protein kinase Cα regulates the nucleocytoplasmic shuttling of KRIT1 [PDF]
Free Radical Biology and Medicine, 2021 ABSTRACT KRIT1 is a scaffolding protein that regulates multiple molecular mechanisms, including cell–cell and cell–matrix adhesion, and redox homeostasis and signaling. However, rather little is known about how KRIT1 is itself regulated.
Elisa De Luca +9 more
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KRIT1 Deficiency Promotes Aortic Endothelial Dysfunction [PDF]
International Journal of Molecular Sciences, 2019 Loss-of-function mutations of the gene encoding Krev interaction trapped protein 1 (KRIT1) are associated with the pathogenesis of Cerebral Cavernous Malformation (CCM), a major cerebrovascular disease characterized by abnormally enlarged and leaky capillaries and affecting 0.5% of the human population. However, growing evidence demonstrates that KRIT1
Vieceli Dalla Sega F. +14 more
openaire +2 more sources
Next-Generation Sequencing Advances the Genetic Diagnosis of Cerebral Cavernous Malformation (CCM)
Antioxidants, 2022 Cerebral Cavernous Malformation (CCM) is a cerebrovascular disease of genetic origin that predisposes to seizures, focal neurological deficits and fatal intracerebral hemorrhage. It may occur sporadically or in familial forms, segregating as an autosomal
Valerio Benedetti +6 more
doaj +1 more source