Results 31 to 40 of about 2,366 (190)

Cancer-secreted exosomal miR-21-5p induces angiogenesis and vascular permeability by targeting KRIT1

Cell Death and Disease, 2021
Cancer-secreted exosomes are critical mediators of cancer-host crosstalk. In the present study, we showed the delivery of miR-21-5p from colorectal cancer (CRC) cells to endothelial cells via exosomes increased the amount of miR-21-5p in recipient cells.
Qinglian He, Aihua Ye, Weibiao Ye, Xiaomin Liao, Guoqiang Qin, Yongqiang Xu, Yuting Yin, Huanqian Luo, Muhua Yi, Liying Xian, Shihao Zhang, Xiyuan Qin, Wei Zhu, Yuling Li   +13 more
doaj   +1 more source

Familial multiple cavernous malformation syndrome : MR features in this uncommon but silent threat [PDF]

, 2016
Cerebral cavernous malformations (CCM) are vascular malformations in the brain and spinal cord. The familial form of cerebral cavernous malformation (FCCM) is uncommon.
Lemmerling, Marc, Mespreuve, Marc, Vanhoenacker, Filip   +2 more
core   +3 more sources

KRIT1 as a possible new player in melanoma aggressiveness

Archives of Biochemistry and Biophysics, 2020
Krev interaction trapped protein 1 (KRIT1) is a scaffold protein known to form functional complexes with distinct proteins, including Malcavernin, PDCD10, Rap1 and others. It appears involved in several cellular signaling pathways and exerts a protective role against inflammation and oxidative stress.
Ercoli J., Finetti F., Woodby B., Belmonte G., Miracco C., Valacchi G., Trabalzini L.   +6 more
openaire   +5 more sources

Up-regulation of NADPH oxidase-mediated redox signaling contributes to the loss of barrier function in KRIT1 deficient endothelium

Scientific Reports, 2017
The intracellular scaffold KRIT1/CCM1 is an established regulator of vascular barrier function. Loss of KRIT1 leads to decreased microvessel barrier function and to the development of the vascular disorder Cerebral Cavernous Malformation (CCM).
Luca Goitre, Peter V. DiStefano, Andrea Moglia, Nicholas Nobiletti, Eva Baldini, Lorenza Trabalzini, Julie Keubel, Eliana Trapani, Vladimir V. Shuvaev, Vladimir R. Muzykantov, Ingrid H. Sarelius, Saverio Francesco Retta, Angela J. Glading   +12 more
doaj   +1 more source

Heg1 and Ccm1/2 proteins control endocardial mechanosensitivity during zebrafish valvulogenesis

eLife, 2018
Endothelial cells respond to different levels of fluid shear stress through adaptations of their mechanosensitivity. Currently, we lack a good understanding of how this contributes to sculpting of the cardiovascular system.
Stefan Donat, Marta Lourenço, Alessio Paolini, Cécile Otten, Marc Renz, Salim Abdelilah-Seyfried   +5 more
doaj   +1 more source

Clinicoradiologic data of familial cerebral cavernous malformation with age‐related disease burden

Annals of Clinical and Translational Neurology, 2023
Objective Familial cerebral cavernous malformation (FCCM) is an autosomal dominant disease induced by loss‐of‐function mutations in three CCM genes, KRIT1, CCM2, and PDCD10.
Seondeuk Kim, Jangsup Moon, Keun‐Hwa Jung, Seon‐Jae Ahn, Han Sang Lee, Yoonhyuk Jang, Kyung‐Il Park, Sang Kun Lee, Kon Chu   +8 more
doaj   +1 more source

Identification of a Novel CCM1 Frameshift Mutation in a Chinese Han Family With Multiple Cerebral Cavernous Malformations

Frontiers in Neuroscience, 2020
Cerebral cavernous malformations (CCMs) are vascular lesions that predominantly occur in the brain. CCMs can be sporadic or hereditary in an autosomal dominant manner. The genes harboring variants of familial CCMs (FCCMs) include CCM1/KRIT1, CCM2/MGC4607,
Fan Zhang, Yiteng Xue, Feng Zhang, Xiaoming Wei, Zhisong Zhou, Zhaoru Ma, Xiaosong Wang, Hong Shen, Yujun Li, Xiaoying Cui, Li Liu   +10 more
doaj   +1 more source

Rap1 and its effector KRIT1/CCM1 regulate β-catenin signaling [PDF]

Disease Models & Mechanisms, 2010
SUMMARYKRIT1, also called CCM1, is a member of a multiprotein complex that contains the products of the CCM2 and PDCD10 (also known as CCM3) loci. Heterozygous loss of any of the genes that encode these proteins leads to cerebral cavernous malformations (CCM), which are vascular lesions that are found in around 0.5% of humans.
Angela J, Glading, Mark H, Ginsberg
openaire   +2 more sources

ANKS1B Interacts with the Cerebral Cavernous Malformation Protein-1 and Controls Endothelial Permeability but Not Sprouting Angiogenesis.

PLoS ONE, 2015
Cerebral cavernous malformations are fragile blood vessel conglomerates in the central nervous system that are caused by mutations in the CCM1/KRIT1, CCM2 or CCM3 genes.
Stefanie E Herberich, Ralph Klose, Iris Moll, Wan-Jen Yang, Joycelyn Wüstehube-Lausch, Andreas Fischer   +5 more
doaj   +1 more source

KRIT1 could serve as a prognostic biomarker for glioma patients

Asian Journal of Surgery
Xiaozhu Zhou, Fanglin Shao, Yujie Xie, Chi Zhang   +3 more
doaj   +3 more sources