Results 241 to 250 of about 157,775 (261)

Berberine improves dietary-induced cardiac remodeling by upregulating Kruppel-like factor 4-dependent mitochondrial function

Biological chemistry, 2021
Multiple studies have showed that berberine protects against heart diseases, including obesity-associated cardiomyopathy. However, it is not fully disclosed the potential molecular mechanisms of berberine on controlling cardiac remodeling.
Laili Ding, Shufeng Li, Fan Wang, Jian Xu, Shaojun Li, Bo Wang, J. Kou, Yongshun Wang, Wei Cao   +8 more
semanticscholar   +1 more source

MiR-32 promotes gastric carcinoma tumorigenesis by targeting Kruppel-like factor 4

Biochemical and Biophysical Research Communications, 2015
Gastric cancer (GC) is a prevalent malignant cancer worldwide and is highly lethal because of its fast growth. Currently, the clinical therapy options for GC remain limited. MiR-32 has been reported as an oncogenic microRNA in many cancers, but its role in GC is unclear.
Chao, Yan, Jianchun, Yu, Yuqin, Liu, Weiming, Kang, Zhiqiang, Ma, Li, Zhou   +5 more
openaire   +2 more sources

Kruppel-like factor 4 expression in osteoblasts represses osteoblast-dependent osteoclast maturation

Cell and Tissue Research, 2014
Kruppel-like factor 4 (KLF4) is a zinc-finger-type transcription factor with a restricted expression pattern during skeletal development. We have previously shown that KLF4 represses osteoblast mineralization concomitant with a down-regulation in the expression of a number of osteoblastic genes, both in vivo and in vitro.
Junji, Fujikawa, Mariko, Tanaka, Shousaku, Itoh, Toshiya, Fukushi, Kojiro, Kurisu, Yuto, Takeuchi, Ichijiro, Morisaki, Satoshi, Wakisaka, Makoto, Abe   +8 more
openaire   +2 more sources

Effect of Kruppel-like factor 4 on Notch pathway in hepatic stellate cells

Journal of Huazhong University of Science and Technology [Medical Sciences], 2016
The relationship between Kruppel-like factor 4 (KLF4) and the Notch pathway was determined to investigate the effect of KLF4 on the activation of hepatic stellate cells and underlying mechanisms. Fifty SPF BALB/c mice were randomly divided into two groups. A liver fibrosis model was established in 25 mice as the experimental group, and the remaining 25
Yin-Kai, Xue, Jun, Tan, Dong-Wei, Dou, Ding, Chen, Lu-Jia, Chen, Huan-Ping, Ren, Li-Bo, Chen, Xin-Gao, Xiong, Hai, Zheng   +8 more
openaire   +2 more sources

Kruppel-like factor 4 upregulates matrix metalloproteinase 13 expression in chondrocytes via mRNA stabilization

Cell and Tissue Research, 2020
Matrix metalloproteinase 13 (MMP13) is indispensable for normal skeletal development and is also a principal proteinase responsible for articular joint pathologies. MMP13 mRNA level needs to be tightly regulated in both positive and negative manners to achieve normal development and also to prevent joint destruction.
Yuto, Takeuchi, Sayuri, Tatsuta, Akiyoshi, Kito, Junji, Fujikawa, Shousaku, Itoh, Yuki, Itoh, Shigehisa, Akiyama, Takashi, Yamashiro, Satoshi, Wakisaka, Makoto, Abe   +9 more
openaire   +2 more sources

Kruppel-like factor 4 regulates matrix metalloproteinase and aggrecanase gene expression in chondrocytes

Cell and Tissue Research, 2017
Kruppel-like factor 4 (KLF4) is a zinc finger transcription factor that plays crucial roles during the development and maintenance of multiple organs. We and others have previously shown that KLF4 is involved in bone modeling and remodeling but roles played by KLF4 during skeletogenesis are still not fully understood.
Junji, Fujikawa, Yuto, Takeuchi, Satoshi, Kanazawa, Ahmed G, Nomir, Akiyoshi, Kito, Eman, Elkhashab, Amr M, Ghaleb, Vincent W, Yang, Shigehisa, Akiyama, Ichijiro, Morisaki, Takashi, Yamashiro, Satoshi, Wakisaka, Makoto, Abe   +12 more
openaire   +2 more sources

Transcription factor Kruppel-like factor 5 positively regulates the expression of AarF domain containing kinase 4

Molecular Biology Reports, 2020
AarF domain containing kinase 4 (ADCK4) is identified as a candidate gene associated with hereditary nephrotic syndrome (NS). Kruppel-like factor 5 (KLF5) is reported to promote podocyte survival by blocking the ERK/p38 MAPK pathways. Both ADCK4 and KLF5 are involved in the occurrence and development of podocyte disease, but their interaction remains ...
Xi Chen, Shuang Liu, Jiahe Chen, Xinyu Wang, Guoping Zhou   +4 more
openaire   +2 more sources

MicroRNA (miR)-429 promotes inflammatory injury by targeting kruppel-like factor 4 (KLF4) in neonatal pneumonia.

Current Neurovascular Research, 2020
BACKGROUND Neonatal pneumonia is a common disease in the neonatal period with a high incidence and death. This study aimed to investigate the molecular mechanism and effect of microRNA (miR)-429 in neonatal pneumonia.
Lan Zhang, Huibo Yan, Huiping Wang, Li Wang, Boling Bai, Yingjun Ma, Y. Tie, Zhaoxia Xi   +7 more
semanticscholar   +1 more source

Abstract 17171: Kruppel-Like Factor 4 Deletion Regulates Lymphatic Endothelial Cell Homeostasis

Circulation, 2018
Introduction and Hypothesis: Lymphatic vasculature exquisitely controls the clearance of metabolic end products, removal of bacterial endotoxins, and trafficking of immune cells. Signaling pathways that converge into endothelial cell kruppel-like factor 4 (KLF4) provide an atheroprotective role; however, the role of lymphatic ...
Victoria Mastej, Cassondra Axen, Kishore Wary   +2 more
openaire   +1 more source

Kruppel‐like Factor 4 is Critical to the Maintenance of Glomerular Endothelial Integrity

The FASEB Journal, 2020
Background Thrombotic microangiopathy (TMA) represents the most severe manifestation of glomerular endothelial injury consisting of endothelial cell (EC) swelling, subendothelial expansion, inflammation and microthrombi.
Chelsea Estrada, Monica Patricia Revelo, Sandeep Mallipattu   +2 more
openaire   +1 more source