Results 91 to 100 of about 193,609 (276)

MicroRNAs-Proteomic Networks Characterizing Human Medulloblastoma-SLCs [PDF]

, 2016
Medulloblastoma (MB) is the most common malignant brain tumor of pediatric age and is characterized by cells expressing stem, astroglial, and neuronal markers.
Alfano, Vincenzo, Besharat, ZEIN MERSINI, Carai, Andrea, Catanzaro, Giuseppina, Ferretti, Elisabetta, Garg, Neha, Locatelli, Franco, Mastronuzzi, Angela, Miele, Evelina, Pieroni, Luisa, Po, Agnese, Ronci, Maurizio, Screpanti, Isabella, Urbani, Andrea   +13 more
core   +4 more sources

Regulation of Corneal Epithelial Barrier Function by Krüppel-like Transcription Factor 4 [PDF]

Investigative Opthalmology & Visual Science, 2011
Previously, the authors showed that Klf4-conditional null (Klf4CN) corneas display epithelial fragility. Here, they investigated the mechanism by which Klf4 regulates corneal epithelial barrier function.Klf4CN mice were generated by breeding Le-Cre with Klf4-LoxP mice. Fluorescein staining was used to test the corneal barrier function.
Sudha, Swamynathan, Doreswamy, Kenchegowda, Joram, Piatigorsky, Shivalingappa, Swamynathan   +3 more
openaire   +3 more sources

A role for ATP-dependent chromatin remodeling in the hierarchical cooperativity between noninteracting transcription factors [PDF]

J. Theor. Biol. 287, 74-81 (2011), 2015
Chromatin remodeling machineries are abundant and diverse in eukaryotic cells. They have been involved in a variety of situations such as histone exchange and DNA repair, but their importance in gene expression remains unclear. Although the influence of nucleosome position on the regulation of gene expression is generally envisioned under the quasi ...
arxiv   +1 more source

Transcriptomic and ChIP-sequence interrogation of EGFR signaling in HER2+ breast cancer cells reveals a dynamic chromatin landscape and S100 genes as targets. [PDF]

, 2019
BACKGROUND:The Human Epidermal Growth Factor Receptor (EGFR/HER1) can be activated by several ligands including Transforming Growth Factor alpha (TGF-α) and Epidermal Growth Factor (EGF).
Dutta, Pranabananda, Farias-Eisner, Robin, Nava, Miguel, Vadgama, Jaydutt V, Wu, Yanyuan, Zemke, Nathan R   +5 more
core   +5 more sources

Role of Esrrg in the Fibrate-Mediated Regulation of Lipid Metabolism Genes in Human ApoA-I Transgenic Mice [PDF]

, 2009
We have used a new ApoA-I transgenic mouse model to identify by global gene expression profiling, candidate genes that affect lipid and lipoprotein metabolism in response to fenofibrate treatment.
A Chroni, A Duka, A Patsialou, A Rigotti, A Walsh, AP Feinberg, B Staels, B Staels, B Staels, B Staels, B Staels, B Staels, BN Finck, CW Miller, D Arsenijevic, D Lan, D Sanoudou, D Sanoudou, D Sanoudou, EM Rubin, ES Cathcart, F Yadetie, G Fredrikson, G Martin, H Duez, H Samyn, HB Rubins, HY Kan, J Karbowska, J Lin, J St Pierre, JC Fruchart, JD Brunzell, JJ Lehman, JK Reddy, JL Goldstein, JM Huss, JM Huss, JP Desager, K C Hayes, K Drosatos, K Motojima, K Schoonjans, K Schoonjans, KE Kypreos, KE Kypreos, KS Frederiksen, L Berthou, LA Pennacchio, LJ Kelly, M Bouly, MB Eisen, MC Hunt, MJ Holness, N Hennuyer, N Vu-Dac, N Vu-Dac, N Vu-Dac, N Vu-Dac, NF Cariello, P Puigserver, Q Guo, R Sladek, RB Vega, RL Jacobs, SA Greenberg, SN Schreiber, V Beisvag, V Giguere, V I Zannis, V Litvak, VG Tusher, VI Zannis, VI Zannis, VI Zannis, WC Roberts, X Prieur, Y Kamei, Y Nagai, Z Wu   +79 more
core   +3 more sources

Mechanism of histone deacetylases in cardiac hypertrophy and its therapeutic inhibitors

Frontiers in Cardiovascular Medicine, 2022
Cardiac hypertrophy is a key process in cardiac remodeling development, leading to ventricle enlargement and heart failure. Recently, studies show the complicated relation between cardiac hypertrophy and epigenetic modification.
Yu Han, Yu Han, Jiali Nie, Jiali Nie, Dao Wen Wang, Dao Wen Wang, Li Ni, Li Ni   +7 more
doaj   +1 more source

PACAP neuropeptide promotes Hepatocellular Protection via CREB-KLF4 dependent autophagy in mouse liver Ischemia Reperfusion Injury. [PDF]

, 2020
Organ ischemia reperfusion injury (IRI), associated with acute hepatocyte death, remains an unresolved problem in clinical orthotopic liver transplantation (OLT).
Busuttil, Ronald W, Gao, Feng, Ji, Haofeng, Kupiec-Weglinski, Jerzy W, Liu, Yuanxing, Shen, Xiu-da, Xue, Zhengze, Zhang, Cheng, Zhang, Yu, Zheng, Shusen   +9 more
core  

Transcriptional profiling of liver during the critical embryo-to-hatchling transition period in the chicken (Gallus gallus)

BMC Genomics, 2018
Background Although hatching is perhaps the most abrupt and profound metabolic challenge that a chicken must undergo; there have been no attempts to functionally map the metabolic pathways induced in liver during the embryo-to-hatchling transition ...
Larry A. Cogburn, Nares Trakooljul, Chuming Chen, Hongzhan Huang, Cathy H. Wu, Wilfrid Carré, Xiaofei Wang, Harold B. White   +7 more
doaj   +1 more source

Control of noise in gene expression by transcriptional reinitiation [PDF]

, 2019
Gene expression is a random or noisy process. The process consists of several random events among which the reinitiation of transcription by RNAP is an important one. The RNAP molecules can bind the gene only after the promoter gets activated by transcription factors.
arxiv   +1 more source

The role of master regulators in gene regulatory networks [PDF]

Papers in Physics 7, 070011 (2015), 2015
Gene regulatory networks present a wide variety of dynamical responses to intrinsic and extrinsic perturbations. Arguably, one of the most important of such coordinated responses is the one of amplification cascades, in which activation of a few key-responsive transcription factors (termed master regulators, MRs) lead to a large series of ...
arxiv   +1 more source