Results 101 to 110 of about 193,609 (276)

Promoter keyholes enable specific and persistent multi-gene expression programs in primary T cells without genome modification [PDF]

, 2020
Non-invasive epigenome editing is a promising strategy for engineering gene expression programs, yet potency, specificity, and persistence remain challenging.
Acosta, Reyes, Baker, David, Bates, Daniel, Bloom, Jordan, Boyken, Scott E., Chen, Zibo, Ciarlo, Christie, Dunn, Douglass, Federation, Alexander, Funnell, Alister, Green, Shon, Heberlein, Gregory, Liao, Hanna, Nandakumar, Vivek, Otterman, Ericka, Pearl, Jocelynn, Queitsch, Konstantin, Sandstrom, Richard, Schanzer, Elaine, Stamatoyannopoulos, John A., Urnov, Fyodor D., Van Biber, Benjamin, Vong, Shinny, Wang, Hao, Wilken, Matthew S., Zrazhevskey, Pavel   +25 more
core  

Role of transcription factors in metastasis of breast cancer

Exploration of Medicine
Metastasis causes a majority of deaths in breast cancer patients. Metastasis is the spread of cancer to distant sites in the body away from the primary tumor, creating secondary tumors, or metastases.
Spoorthi Marada, Chikezie Madu, Yi Lu
doaj   +1 more source

Network analysis of KLF5 targets showing the potential oncogenic role of SNHG12 in colorectal cancer

Cancer Cell International, 2020
Background KLF5 is a member of the Kruppel-like factor, subfamily of zinc finger proteins that are involved in cancers. KLF5 functions as a transcription factor and regulates the diverse protein-coding genes (PCGs) in colorectal cancer (CRC).
Qi Liao, Linbo Chen, Ning Zhang, Yang Xi, Shiyun Hu, Derry Minyao Ng, Fatma Yislam Hadi Ahmed, Guofang Zhao, Xiaoxiang Fan, Yangyang Xie, Xiaoyu Dai, Yanping Jin, Jiaxin Ge, Changzheng Dong, Xinjun Zhang, Junming Guo   +15 more
doaj   +1 more source

KLF2 is a clinical diagnostic and treatment biomarker of breast cancer

Frontiers in Cell and Developmental Biology, 2023
Background: As a highly prevalent malignancy among women worldwide, breast cancer, remains a critical public health issue necessitating the development of novel therapeutics and biomarkers.
Ya-Zhao Li, Ya-Zhao Li, Juan Xie, Rui-Qi Wang, Rui-Qi Wang, Xiao-Qian Gao, Xiao-Qian Gao, Pei-Jun Liu, Pei-Jun Liu, Jie Liu, Jie Liu   +10 more
doaj   +1 more source

A global role for KLF1 in erythropoiesis revealed by ChIP-seq in primary erythroid cells [PDF]

, 2010
KLF1 regulates a diverse suite of genes to direct erythroid cell differentiation from bipotent progenitors. To determine the local cis-regulatory contexts and transcription factor networks in which KLF1 operates, we performed KLF1 ChIP-seq in the mouse ...
Bailey, Timothy L., Cloonan, Nicole, Gardiner, Brooke B., Grimmond, Sean M., Keys, Janelle R., Nourbakhsh, Ehsan, Perkins, Andrew C., Tallack, Michael R., Wainwright, Elanor N., Whitington, Tom, Yuen, Wai Shan   +10 more
core   +1 more source

Global Mapping of H3K4 Trimethylation (H3K4me3) and Transcriptome Analysis Reveal Genes Involved in the Response to Epidemic Diarrhea Virus Infections in Pigs

Animals, 2019
Porcine epidemic diarrhea virus (PEDV) is currently detected as the main pathogen causing severe diarrhea in pig farms. The phenotypic alterations induced by pathogenic infections are usually tightly linked with marked changes in epigenetic modification ...
Haifei Wang, Li Yang, Huan Qu, Haiyue Feng, Shenglong Wu, Wenbin Bao   +5 more
doaj   +1 more source

Post-transcriptional regulation across human tissues [PDF]

PLoS Comput Biol 13(5): e1005535 (2017), 2015
Transcriptional and post-transcriptional regulation shape tissue-type-specific proteomes, but their relative contributions remain contested. Estimates of the factors determining protein levels in human tissues do not distinguish between (i) the factors determining the variability between the abundances of different proteins, i.e., mean-level ...
arxiv   +1 more source

The CACCC-binding protein KLF3/BKLF represses a subset of KLF1/EKLF target genes and is required for proper erythroid maturation in vivo [PDF]

, 2012
The CACCC-box binding protein erythroid Kruppel-like factor (EKLF/KLF1) is a master regulator that directs the expression of many important erythroid genes.
Borg J, Coghill E, Eaton SA, Enomoto T, Feng WC, Hancock D, Henderson NC, Hodge D, Nuez B, Paulson RF, Pearson R, Pearson RC, Perkins AC, Sears DA, Shi Y, Socolovsky M, Tallack MR, Tallack MR, Turner J, Turner J, Vu TT, Zhang J, Zhang W   +22 more
core   +1 more source

Dynamics of gene expression and the regulatory inference problem [PDF]

, 2007
From the response to external stimuli to cell division and death, the dynamics of living cells is based on the expression of specific genes at specific times. The decision when to express a gene is implemented by the binding and unbinding of transcription factor molecules to regulatory DNA.
arxiv   +1 more source

Functional Evolution of cis-Regulatory Modules at a Homeotic Gene in Drosophila [PDF]

, 2011
It is a long-held belief in evolutionary biology that the rate of molecular evolution for a given DNA sequence is inversely related to the level of functional constraint.
Allen, John M, Bae, Esther, Bender, Welcome W., Celniker, Susan E., Drewell, Robert A., Fisher, William W., Goetz, Sara E., Ho, Margaret C. W., Johnsen, Holly, Rau, Christoph, Schiller, Benjamin J., Shur, Andrey S., Tran, Diana A.   +12 more
core   +1 more source