Results 101 to 110 of about 33,501 (214)

CRISPR Enabled Precision Oncology: From Gene Editing to Tumor Microenvironment Remodeling

Med Research, EarlyView.
CRISPR technology has progressed from a prokaryotic immune system to a diverse suite of editing platforms, including Cas nucleases, base and prime editors, and RNA‐targeting enzymes. These advances enable precise genomic and epigenomic interventions, high‐throughput functional screening, and immune engineering.
Kailai Li, Peixin Huang, Yue Qian, Anqi Lin, Jingjun He, Junyi Shen, Li Chen, Kai Miao, Jian Zhang   +8 more
wiley   +1 more source

Mesenchymal Stromal Cells from Neonatal Tracheal Aspirates Demonstrate a Pattern of Lung-Specific Gene Expression [PDF]

, 2011
We have previously isolated mesenchymal stromal cells (MSCs) from the tracheal aspirates of premature neonates with respiratory distress. Although isolation of MSCs correlates with the development of bronchopulmonary dysplasia, the physiologic role of ...
Adam M. Goldsmith, Antonia P. Popova, Benjamini Y, Daniel J. Weiss, in't Anker PS, John Kelley Bentley, Lindahl P, Marc B. Hershenson, Marisa J. Linn, Paul D. Bozyk, Scotton CJ, Wong AP, Yamaguchi TP   +12 more
core   +1 more source

Regulation of Corneal Epithelial Barrier Function by Krüppel-like Transcription Factor 4 [PDF]

Investigative Opthalmology & Visual Science, 2011
Previously, the authors showed that Klf4-conditional null (Klf4CN) corneas display epithelial fragility. Here, they investigated the mechanism by which Klf4 regulates corneal epithelial barrier function.Klf4CN mice were generated by breeding Le-Cre with Klf4-LoxP mice. Fluorescein staining was used to test the corneal barrier function.
Sudha, Swamynathan, Doreswamy, Kenchegowda, Joram, Piatigorsky, Shivalingappa, Swamynathan   +3 more
openaire   +2 more sources

Circadian Immunity and Vascular Inflammation in Cardiovascular Disease Chronotherapy Windows: Time for a Re‐Assessment

Med Research, EarlyView.
ABSTRACT Circadian rhythms orchestrate cardiovascular physiology by regulating immune and inflammatory pathways. Disruption of these rhythms profoundly alters vascular homeostasis, thereby promoting the onset and progression of cardiovascular diseases (CVD).
Tian Zhang, Ge Zhang, Tian‐Ding Liu, Tianshu Gu, Fengyi Yu, Pengyuan Xu, Wunan Mi, Xuanjiang Zhao, Qian Guo, Honglin Zheng, Taiqi Zhao, Qiang Li, Di Lu, Mingxuan Duan, Chaoyang Yu, Ruhao Wu, Shiqian Zhang, Haonan Zhang, Zeyu Wang, Youyang Zheng, Yan Xiao, Zenglei Zhang, Ge Zhang   +22 more
wiley   +1 more source

Stress Can Induce Bovine Alpha-Herpesvirus 1 (BoHV-1) Reactivation from Latency

Viruses
Bovine alpha-herpesvirus 1 (BoHV-1) is a significant problem for the cattle industry, in part because the virus establishes latency, and stressful stimuli increase the incidence of reactivation from latency.
Fouad El-Mayet, Clinton Jones
doaj   +1 more source

Characterization of Carotid Smooth Muscle Cells during Phenotypic Transition [PDF]

, 2018
Vascular smooth muscle cells (VSMCs) are central players in carotid atherosclerosis plaque development. Although the precise mechanisms involved in plaque destabilization are not completely understood, it is known that VSMC proliferation and migration ...
Alloza Moral, Iraide, Elizagaray, Elena, Freijo, María del Mar, Goikuria Iriondo, Haize, Lorenzo, Ana, Sastre, María, Vandenbroeck, Koen, Vega Manrique, Reyes   +7 more
core   +3 more sources

Krüppel-like Factor 5 Transcription Factor Promotes Microsomal Prostaglandin E2 Synthase 1 Gene Transcription in Breast Cancer [PDF]

Journal of Biological Chemistry, 2013
The KLF5 (Krüppel-like factor 5) transcription factor is specifically expressed in a subset of estrogen receptor α-negative breast cancers. Although KLF5 promotes breast cancer cell cycle progression, survival, and tumorigenesis, the mechanism by which KLF5 promotes breast cancer is still not entirely understood.
Houjun, Xia, Chunyan, Wang, Wenlin, Chen, Hailin, Zhang, Leena, Chaudhury, Zhongmei, Zhou, Rong, Liu, Ceshi, Chen   +7 more
openaire   +2 more sources

Juvenile hormone‐mediated accelerated post‐flight recovery of ovarian development in Loxostege sticticalis (Lepidoptera: Crambidae)

New Plant Protection, EarlyView.
Flight in female beet webworms (Loxostege sticticalis) promotes an increase in feeding, thereby enhancing abdominal energy reserves. Following flight, the flight muscles undergo accelerated histolysis, and the energy substances undergoing histolysis are redirected to the ovaries. These two processes collectively promote ovarian development.
Yu Gao, Yunxia Cheng, Wenyi Song, Lei Zhang, Dianjie Xie, Xingfu Jiang   +5 more
wiley   +1 more source

The reprogramming factor KLF4 in normal and malignant blood cells

Frontiers in Immunology
The Krüppel-like factor 4 (KLF4) is an evolutionarily conserved zinc finger transcription factor that regulates cellular processes in stem cells, epithelial cells, and immune blood cells by controlling gene expression through genetic, epigenetic, and ...
H. Daniel Lacorazza
doaj   +1 more source

Methylated cis-regulatory elements mediate KLF4-dependent gene transactivation and cell migration

eLife, 2017
Altered DNA methylation status is associated with human diseases and cancer; however, the underlying molecular mechanisms remain elusive. We previously identified many human transcription factors, including Krüppel-like factor 4 (KLF4), as sequence ...
Jun Wan, Yijing Su, Qifeng Song, Brian Tung, Olutobi Oyinlade, Sheng Liu, Mingyao Ying, Guo-li Ming, Hongjun Song, Jiang Qian, Heng Zhu, Shuli Xia   +11 more
doaj   +1 more source