Results 121 to 130 of about 33,501 (214)

The involvement of krüppel-like transcription factor 2 in megakaryocytic differentiation induction by phorbol 12-myrestrat 13-acetate

Biomarker Research
Background Megakaryocytic differentiation is a complicated process regulated by a series of transcription factors in a context- and stage-dependent manner.
Zhen Wang, Zhongwen Liu, Pan Zhou, Xiaona Niu, Zhengdao Sun, Huan He, Zunmin Zhu   +6 more
doaj   +1 more source

Macrophage phenotype in response to ECM bioscaffolds [PDF]

, 2017
Macrophage presence and phenotype are critical determinants of the healing response following injury. Downregulation of the pro-inflammatory macrophage phenotype has been associated with the therapeutic use of bioscaffolds composed of extracellular ...
Badylak, Stephen F, Bartolacci, Joseph G., Brown, Bryan N., Cramer, Madeline C., Dziki, Jenna L., Huleihel, Luai, LoPresti, Samuel T., Rausch, Theresa, Scarritt, Michelle E., Swinehart, Ilea T., Vorobyov, Tatiana, White, Lisa J.   +11 more
core   +2 more sources

Krüppel-Like Factor 4 [PDF]

Circulation Research, 2008
See related article, pages 1548–1557 The transcriptional response to vascular injury. The vascular response to injury is a dynamic and multifactorial process involving several cell types. As part of the vascular response to injury, normally quiescent, contractile vascular smooth muscle cells (VSMCs) respond to inflammatory and growth factors by ...
openaire   +2 more sources

Elevated CO2 and Temperature Alter Grass Pollen's Ability to Modify Transcriptome and Function of the Nasal Epithelium

Allergy, EarlyView.
We exposed human nasal epithelial tissues to pollen from grasses grown under different climate treatments (temperature and CO2). Pollen weakened epithelial tight junctions and altered cytokine‐related gene expression, with similar protein‐level effects.
Tarleena Tossavainen, Tanja Turunen, Maria‐Viola Martikainen, Miisa Kankaanpää, Marjo Malinen, Marjut Roponen   +5 more
wiley   +1 more source

C‐X‐C chemokine receptor CXCR4 mediates diurnal changes in the aggregation and dispersion of CD8+ T cells within the tumor microenvironment

International Journal of Cancer, Volume 158, Issue 6, Page 1740-1754, 15 March 2026.
What's new? In addition to governing daily variations in biological activity, the circadian clock regulates immune cell migration into tumors. Whether this influence extends to immune cell localization within the tumor microenvironment (TME) is unknown. Here, using cell and animal models, the authors investigated immune cell distribution within the TME
Akito Tsuruta, Marina Fujimoto, Yasuha Hiraoka, Aoi Taniguchi, Yuki Shiiba, Takuto Inoki, Tomoaki Yamauchi, Yuya Yoshida, Naoya Matsunaga, Shigehiro Ohdo, Satoru Koyanagi   +10 more
wiley   +1 more source

Role of FGFR2b expression and signaling in keratinocyte differentiation. Sequential involvement of PKCδ and PKCα [PDF]

, 2018
The tumor suppressor epithelial isoform of the fibroblast growth factor receptor 2 (FGFR2b) induces human keratinocyte early differentiation. Moreover, protein kinases C (PKCs) are known to regulate the differentiation program in several cellular ...
Belleudi, Francesca, Nanni, Monica, Ranieri, Danilo, Rosato, Benedetta, Torrisi, Maria Rosaria   +4 more
core   +2 more sources

Human Cyclophilins—An Emerging Class of Drug Targets

Medicinal Research Reviews, Volume 46, Issue 2, Page 475-512, March 2026.
ABSTRACT Cyclophilins are a family of enzymes with peptidyl‐prolyl isomerase activity found in all cells of all organisms. To date, 17 cyclophilin isoforms have been identified in the human body, participating in diverse biological processes. Consequently, cyclophilins have emerged as promising targets for drug development to address a wide array of ...
Katarina Jurkova, Hana Navratilova, Kamil Musilek, Ondrej Benek   +3 more
wiley   +1 more source

KAP1 is a Novel Substrate for the Arginine Methyltransferase PRMT5 [PDF]

, 2015
KRAB-associated protein 1 (KAP1), the transcriptional corepressor of Kruppel-associated box zinc finger proteins (KRAB-ZFPs), is subjected to multiple post-translational modifications that are involved in fine-tuning of the multiple biological functions ...
Cesaro, Elena, Ciano, Michela, Costanzo, Paola, Di Caprio, Roberta, Montano, Giorgia   +4 more
core   +2 more sources

Kruppel-Like Transcription Factor-4 Gene Expression and DNA Methylation Status in Type 2 Diabetes and Diabetic Nephropathy Patients

Archives of Medical Research, 2019
Diabetic nephropathy (DN) is one of the most serious microvascular complications in diabetic patients. The kruppel-like transcription factor-4 (KLF-4) affects the expression of genes involved in the pathogenesis of DN. The present study aims to identify the KLF-4 expression and DNA methylation (DNAMe) status in patients with type-2 diabetes (T2D) and ...
Coşkun, Zeynep Mine, Ersöz, Melike, Adaş, Mine, Hançer, Veysel Sabri, Boysan, Şerife Nur, Gönen, Mustafa Sait, Acar, Aynur   +6 more
openaire   +4 more sources

Aging‐Derived Alterations in Genomic, Immune, and Metabolic Networks: Implications for Cancer Development and Therapy

MedComm – Oncology, Volume 5, Issue 1, March 2026.
Ageing acts as a double‐edged sword in cancer. In the elderly, open chromatin, immunosenescence, and chronic inflammation drive SASP (IL‐6, MMPs), MDSC accumulation and T‐cell suppression, fostering tumor‐promoting microenvironments and limited therapeutic benefit.
Qi Wang, Xue Sun, Xinhao Han, Xingda Zhang, Wenzheng Wang, Hongbin Wang, He Ren, Lina Gu   +7 more
wiley   +1 more source