Results 121 to 130 of about 193,609 (276)

Stochastic analysis of bistability in coherent mixed feedback loops combining transcriptional and post-transcriptional regulations [PDF]

, 2014
Mixed feedback loops combining transcriptional and post-transcriptional regulations are common in cellular regulatory networks. They consist of two genes, encoding a transcription factor and a small non-coding RNA (sRNA), which mutually regulate each other's expression.
arxiv   +1 more source

Different parts of the mussel Gigantidas haimaensis holobiont responded differently to deep‐sea sampling stress

Integrative Zoology, EarlyView.
Symbiotic gill and nonsymbiotic mantle of mussel Gigantidas haimaensis responded differently to deep‐sea sampling stress caused by acute environmental changes. Sharply increased transcription factors potentially play key roles in initiating the response of sampled deep‐sea macrobenthos to the sampling stress.
Guoyong YAN, Tong WEI, Yi LAN, Ting XU, Peiyuan QIAN   +4 more
wiley   +1 more source

Gene Expression Profile Changes After Short-activating RNA-mediated Induction of Endogenous Pluripotency Factors in Human Mesenchymal Stem Cells [PDF]

, 2012
It is now recognized that small noncoding RNA sequences have the ability to mediate transcriptional activation of specific target genes in human cells.
Alluin, J, Habib, N, Kasahara, N, Mintz, P, Rossi, J, Sun, G, Sætrom, P, Voutila, J   +7 more
core   +4 more sources

Depletion of Kruppel-like factor 15 sensitized gliomas to temozolomide cytotoxicity through O6-methylguanine-DNA methyl-transferase

Biochemistry and Biophysics Reports, 2021
Temozolomide (TMZ)-based chemotherapy is a standard strategy for gliomas, although chemoresistance remains a major therapeutic challenge. The chemical mechanism by which TMZ induces cell death is DNA methylation, leading to double-stranded breaks (DSBs ...
Xinjuan Qu, Xuelai Liu, Yumei Zhang, Zhan Shi, Xiaohua Wang   +4 more
doaj  

Reliable scaling of Position Weight Matrices for binding strength comparisons between transcription factors [PDF]

arXiv, 2015
Scoring DNA sequences against Position Weight Matrices (PWMs) is a widely adopted method to identify putative transcription factor binding sites. While common bioinformatics tools produce scores that can reflect the binding strength between a specific transcription factor and the DNA, these scores are not directly comparable between different ...
arxiv  

Single‐Nucleus RNA Sequencing and Spatial Transcriptomics for Squamous Cell Carcinoma Arising From Ovarian Mature Teratoma

Cancer Science, Volume 116, Issue 5, Page 1339-1351, May 2025.
Single‐nucleus RNA‐seq identified KLF5 as an upregulated gene in SCC‐MT cells. Spatial transcriptomics showed inhibited EMT in SCC‐MT cells. KLF5 downregulation reduced SCC‐MT cell proliferation and increased apoptosis. ABSTRACT Squamous cell carcinoma arising from mature teratoma (SCC‐MT) is a rare ovarian malignancy.
Kosuke Yoshida, Akira Yokoi, Hironori Suzuki, Satoshi Tamauchi, Masami Kitagawa, Eri Inami, Jun Nakayama, Yutaro Mori, Koji Okamoto, Yutaka Suzuki, Hiroshi Yoshida, Tomoyasu Kato, Hiroaki Kajiyama, Yusuke Yamamoto   +13 more
wiley   +1 more source

New insights into the anti-inflammatory mechanisms of glucocorticoids : an emerging role for glucocorticoid-receptor-mediated transactivation [PDF]

, 2013
Glucocorticoids are anti-inflammatory drugs that are widely used for the treatment of numerous (autoimmune) inflammatory diseases. They exert their actions by binding to the glucocorticoid receptor (GR), a member of the nuclear receptor family of ...
Dejager, Lien, Libert, Claude, Tuckermann, Jan, Vandevyver, Sofie   +3 more
core   +1 more source

Lactate and Lactylation in AKI‐to‐CKD: Epigenetic Regulation and Therapeutic Opportunities

Cell Proliferation, EarlyView.
ABSTRACT Lactate is not only a byproduct of glycolysis, but is also considered an energy source, gluconeogenic precursor, signalling molecule and protein modifier during the process of cellular metabolism. The discovery of lactylation reveals the multifaceted functions of lactate in cellular metabolism and opens new avenues for lactate‐related research.
Yi Hou, Dongwei Liu, Zuishuang Guo, Cien Wei, Fengyu Cao, Yue Xu, Qi Feng, Fengxun Liu   +7 more
wiley   +1 more source

tRNA-Derived Small Non-Coding RNAs as Novel Epigenetic Molecules Regulating Adipogenesis

Biomolecules, 2019
tRNA-derived fragments (tRFs), a novel type of non-coding RNA derived from tRNAs, play an important part in governing gene expressions at a post-transcriptional level. To date, the regulatory mechanism of tRFs governing fat deposition and adipogenesis is
Linyuan Shen, Zhendong Tan, Mailin Gan, Qiang Li, Lei Chen, Lili Niu, Dongmei Jiang, Ye Zhao, Jinyong Wang, Xuewei Li, Shunhua Zhang, Li Zhu   +11 more
doaj   +1 more source

Fundamental Dynamic Units: Feedforward Networks and Adjustable Gates [PDF]

arXiv, 2009
The activation/repression of a given gene is typically regulated by multiple transcription factors (TFs) that bind at the gene regulatory region and recruit RNA polymerase (RNAP). The interactions between the promoter region and TFs and between different TFs specify the dynamic responses of the gene under different physiological conditions. By choosing
arxiv