Possible role of Krüppel-like factor 5 in the remodeling of small airways and pulmonary vessels in chronic obstructive pulmonary disease [PDF]
, 2016 BACKGROUND: Small airway remodeling is an important cause of the airflow limitation in chronic obstructive pulmonary disease (COPD). A large population of patients with COPD also have pulmonary hypertension.
Abe, K +14 more
core +2 more sources
Transcriptional repression of WEE1 by Kruppel-like factor 2 is involved in DNA damage-induced apoptosis [PDF]
Oncogene, 2005 Human Kruppel-like factor 2 (KLF2) is a Cys(2)/His(2) zinc-finger-containing transcriptional factor, which is involved in multiple cellular pathways. Utilizing gene expression profiling to identify aberrantly expressed genes in ovarian cancer, we found that KLF2 was significantly and specifically downregulated in ovarian tumors.
Ngan, HYS +12 more
openaire +4 more sources
Transcription Factors as Therapeutic Targets in Chronic Kidney Disease
Molecules, 2018 The growing number of patients with chronic kidney disease (CKD) is recognized as an emerging problem worldwide. Recent studies have indicated that deregulation of transcription factors is associated with the onset or progression of kidney disease ...
Akihito Hishikawa +2 more
doaj +1 more source
Luna, a Drosophila KLF6/KLF7, is maternally required for synchronized nuclear and centrosome cycles in the preblastoderm embryo. [PDF]
PLoS ONE, 2014 Krüppel like factors (KLFs) are conserved transcription factors that have been implicated in many developmental processes including differentiation, organ patterning, or regulation of stem cell pluripotency.
Ursula Weber +3 more
doaj +1 more source
Functional Evolution of cis-Regulatory Modules at a Homeotic Gene in Drosophila [PDF]
, 2011 It is a long-held belief in evolutionary biology that the rate of molecular evolution for a given DNA sequence is inversely related to the level of functional constraint.
Allen, John M +12 more
core +1 more source
VIP contribution to the decidualization program: regulatory T cell recruitment [PDF]
, 2014 During early pregnancy, the human uterus undergoes profound tissue remodeling characterized by leukocyte invasion and production of proinflammatory cytokines, followed by tissue repair and tolerance maintenance induction.
Agüero, Mariana +5 more
core +1 more source
Simvastatin has an anti-inflammatory effect on macrophages via upregulation of an atheroprotective transcription factor, Kruppel-like factor 2 [PDF]
Cardiovascular Research, 2008 Statins have beneficial vascular effects beyond their cholesterol-lowering action. Since macrophages play a central role in atherogenesis, we characterized the effects of simvastatin on gene expression profile of human peripheral blood monocyte (HPBM)-macrophages.Gene expression profile was studied using Affymetrix gene chip analysis.
Tuomisto, Tiina T. +9 more
openaire +4 more sources
Gene Expression Profile Changes After Short-activating RNA-mediated Induction of Endogenous Pluripotency Factors in Human Mesenchymal Stem Cells [PDF]
, 2012 It is now recognized that small noncoding RNA sequences have the ability to mediate transcriptional activation of specific target genes in human cells.
Alluin, J +7 more
core +4 more sources
The Role of KLF4 in Alzheimer’s Disease
Frontiers in Cellular Neuroscience, 2018 Krüppel-like factor 4 (KLF4), a member of the family of zinc-finger transcription factors, is widely expressed in range of tissues that play multiple functions.
Ziqian Cheng +6 more
doaj +1 more source
MicroRNA-1 Regulates Smooth Muscle Cell Differentiation by Repressing Kruppel-Like Factor 4 [PDF]
, 2011 The role of microRNA-1 (miR-1) has been studied in cardiac and skeletal muscle differentiation. However, it remains unexplored in vascular smooth muscle cells (SMCs) differentiation. The aim of this study was to uncover novel targets of and shed light on
Changqing Xie +9 more
core +2 more sources