Krüppel-like transcription factors KLF1 and KLF2 have unique and coordinate roles in regulating embryonic erythroid precursor maturation. [PDF]
Haematologica, 2014 Vinjamur DS +5 more
europepmc +3 more sources
Repression of cardiac hypertrophy by KLF15: underlying mechanisms and therapeutic implications. [PDF]
PLoS ONE, 2012 The Kruppel-like factor (KLF) family of transcription factors regulates diverse cell biological processes including proliferation, differentiation, survival and growth. Previous studies have shown that KLF15 inhibits cardiac hypertrophy by repressing the
Joost J Leenders +8 more
doaj +1 more source
Neural Regeneration Research, 2023 The key regulators and regeneration-associated genes involved in axonal regeneration of neurons after injury have not been clarified. In high-throughput sequencing, various factors influence the final sequencing results, including the number and size of ...
Li-Li Zhao +4 more
doaj +1 more source
ZNF224 Protein: Multifaceted Functions Based on Its Molecular Partners
Molecules, 2021 The transcription factor ZNF224 is a Kruppel-like zinc finger protein that consists of 707 amino acids and contains 19 tandemly repeated C2H2 zinc finger domains that mediate DNA binding and protein–protein interactions.
Elena Cesaro +5 more
doaj +1 more source
Regulation and Function of the Cancer Stem Cell Transcription Factors GLI1 and Kruppel-like Factor 4
, 2019 Daniel B. Vanderbilt
openaire +3 more sources
Klf4 is a transcriptional regulator of genes critical for EMT, including Jnk1 (Mapk8). [PDF]
PLoS ONE, 2013 We have identified the zinc-finger transcription factor Kruppel-like factor 4 (Klf4) among the transcription factors that are significantly downregulated in their expression during epithelial-mesenchymal transition (EMT) in mammary epithelial cells and ...
Neha Tiwari +6 more
doaj +1 more source
CHIR99021 enhances Klf4 Expression through β-Catenin Signaling and miR-7a Regulation in J1 Mouse Embryonic Stem Cells. [PDF]
PLoS ONE, 2016 Understanding the mechanisms that regulate pluripotency of embryonic stem cells (ESCs) is important to ensure their safe clinical use. CHIR99021 (CHIR)-induced activation of Wnt/β-catenin signaling promotes self-renewal in mouse ESCs (mESCs).
Zhiying Ai +8 more
doaj +1 more source
Transcriptional regulation of neural stem cell expansion in the adult hippocampus
eLife, 2022 Experience governs neurogenesis from radial-glial neural stem cells (RGLs) in the adult hippocampus to support memory. Transcription factors (TFs) in RGLs integrate physiological signals to dictate self-renewal division mode.
Nannan Guo +12 more
doaj +1 more source
Possible role of Krüppel-like factor 5 in the remodeling of small airways and pulmonary vessels in chronic obstructive pulmonary disease [PDF]
, 2016 BACKGROUND: Small airway remodeling is an important cause of the airflow limitation in chronic obstructive pulmonary disease (COPD). A large population of patients with COPD also have pulmonary hypertension.
Abe, K +14 more
core +4 more sources
Kruppel-like factor 8 regulates triple negative breast cancer stem cell-like activity
Frontiers in Oncology, 2023 IntroductionBreast tumor development is regulated by a sub-population of breast cancer cells, termed cancer stem-like cells (CSC), which are capable of self-renewing and differentiating, and are involved in promoting breast cancer invasion, metastasis ...
Giang Le Minh +7 more
doaj +1 more source