Results 111 to 120 of about 22,488 (214)

Extracellular Vesicles From KSHV-Infected Cells Stimulate Antiviral Immune Response Through Mitochondrial DNA

Frontiers in Immunology, 2019
Kaposi's Sarcoma-associated herpesvirus (KSHV) is the etiologic agent of Kaposi's sarcoma, which is the most common cancer in acquired immune deficiency syndrome patients. KSHV contains a variety of immunoregulatory proteins. There have been many studies
Hyungtaek Jeon, Jisu Lee, Suhyuk Lee, Su-Kyung Kang, Sang June Park, Seung-Min Yoo, Myung-Shin Lee   +6 more
doaj   +1 more source

Kaposi’s Sarcoma-Associated Herpesvirus-Encoded circRNAs Are Expressed in Infected Tumor Tissues and Are Incorporated into Virions

mBio, 2020
Kaposi’s sarcoma-associated herpesvirus (KSHV) has recently been found to generate circular RNAs (circRNAs) from several KSHV genes, most abundantly from K10 (viral interferon regulatory factor 4 [vIRF4]), K7.3, and polyadenylated nuclear (PAN) RNA.
Bizunesh Abere, Jinghui Li, Hongzhao Zhou, Tuna Toptan, Patrick S. Moore, Yuan Chang   +5 more
doaj   +1 more source

An Interaction between KSHV ORF57 and UIF Provides mRNA-Adaptor Redundancy in Herpesvirus Intronless mRNA Export [PDF]

, 2011
The hTREX complex mediates cellular bulk mRNA nuclear export by recruiting the nuclear export factor, TAP, via a direct interaction with the export adaptor, Aly.
Blackbourn, D.J., Boyne, J.R., Hautbergue, G.M., Jackson, B.R., Noerenberg, M., Taylor, A., Walsh, M.J., Wheat, R., Whitehouse, A., Wilson, S.A.   +9 more
core   +4 more sources

Harnessing viral footprints in circulating free DNA (cfDNA) for early cancer detection: A focus on liquid‐biopsy‐based screening

International Journal of Cancer, Volume 158, Issue 3, Page 511-526, 1 February 2026.
Abstract Viral infections play a significant role in cancer development, making detecting viral signatures a promising approach for early cancer diagnosis. Circulating free DNA (cfDNA), released into the bloodstream by tumors and other cells, has emerged as a powerful biomarker for non‐invasive cancer screening.
Richard Donkor Amponsah, Emmanuel Addai Gyabaah, Moro Amidu, Zhao Cheng, Fazlur Rahman Talukdar   +4 more
wiley   +1 more source

Allicin and Glycyrrhizic Acid Display Antiviral Activity Against Latent and Lytic Kaposi Sarcoma-associated Herpesvirus

Infectious Microbes & Diseases, 2020
. Kaposi sarcoma-associated herpesvirus (KSHV) triggers the development of Kaposi sarcoma, a skin malignancy that is one of the most widespread defining symptoms in acquired immunodeficiency syndrome patients.
Yirui Xie, Ying Chen, Yongzheng Guo, Ying Huang, Biao Zhu, Stijn van der Veen   +5 more
doaj   +1 more source

Differential regulation of translational stress responses by herpesvirus ubiquitin deconjugases

The FEBS Journal, Volume 293, Issue 4, Page 1024-1044, February 2026.
Translating viral mRNAs is challenging due to structural features that may slow translation or induce ribosome stalling. The viral ubiquitin deconjugases encoded by human pathogenic herpesviruses regulate the cellular response to ribosomal stress by inhibiting various branches of the Ribosomal Quality Control (RQC) and activating Ribosomal Stress ...
Jiangnan Liu, Noemi Nagy, Carlos Mario Ayala‐Torres, Maria G. Masucci   +3 more
wiley   +1 more source

Pathology of Kaposi's sarcoma-associated herpesvirus infection

Frontiers in Microbiology, 2011
Kaposi’s sarcoma-associated herpesvirus (KSHV, human herpesvirus 8, HHV-8) is a human herpesvirus, classified as a gamma-herpesvirus. KSHV is detected in Kaposi’s sarcoma (KS), primary effusion lymphoma (PEL), and some cases of multicentric Castleman’s ...
Hitomi eFukumoto, Hitomi eFukumoto, Takayuki eKanno, Hideki eHasegawa, Harutaka eKatano   +4 more
doaj   +1 more source

Signatures of oral microbiome in HIV-infected individuals with oral Kaposi's sarcoma and cell-associated KSHV DNA.

PLoS Pathogens, 2020
Infection by Kaposi's sarcoma-associated herpesvirus (KSHV) is necessary for the development of Kaposi's sarcoma (KS), which most often develops in HIV-infected individuals. KS frequently has oral manifestations and KSHV DNA can be detected in oral cells.
Marion Gruffaz, Tinghe Zhang, Vickie Marshall, Priscila Gonçalves, Ramya Ramaswami, Nazzarena Labo, Denise Whitby, Thomas S Uldrick, Robert Yarchoan, Yufei Huang, Shou-Jiang Gao   +10 more
doaj   +1 more source

Identification of Target Genes Regulated by KSHV miRNAs in KSHV-Infected Lymphoma Cells

Pathology & Oncology Research, 2015
This study aimed to identify target genes regulated by KSHV miRNAs in KSHV-infected lymphoma cells. Original Ago HITS-CLIP data of BC-3 and BCBL-1 cell lines were downloaded from SRA database in NCBI, including mRNA and miRNA samples. The raw mRNA reads were mapped into human reference genome hg19 via TopHat for read alignment.
Liangliang, Quan, Tao, Qiu, Jiulong, Liang, Miao, Li, Yu, Zhang, Kai, Tao   +5 more
openaire   +2 more sources

Generation of chimeric forms of rhesus macaque rhadinovirus expressing KSHV envelope glycoproteins gH and gL for utilization in an NHP model of infection

Journal of Virology
Kaposi’s sarcoma-associated herpesvirus (KSHV) is a human gammaherpesvirus associated with Kaposi’s sarcoma and B cell malignancies. Like all herpesviruses, KSHV contains conserved envelope glycoproteins (gps) involved in virus binding, entry, assembly ...
Ryan D. Estep, Helen Li, Aparna N. Govindan, Kaidlyn A. McDonald, Michael K. Axthelm, Scott W. Wong   +5 more
doaj   +1 more source