Results 111 to 120 of about 16,928 (247)

LANA-Mediated Recruitment of Host Polycomb Repressive Complexes onto the KSHV Genome during De Novo Infection

PLoS Pathogens, 2016
One of the hallmarks of the latent phase of Kaposi’s sarcoma-associated herpesvirus (KSHV) infection is the global repression of lytic viral gene expression.
Z. Tóth, Bernadett Papp, Kevin F. Brulois, Younho Choi, Shou-Jiang Gao, Jae U. Jung   +5 more
semanticscholar   +1 more source

Animal models of human herpesvirus infection

Animal Models and Experimental Medicine, Volume 8, Issue 4, Page 615-628, April 2025.
Human herpesvirus can infect humans and other vertebrates, primarily targeting the skin, mucous membranes, and neural tissues, thereby significantly impacting the health of both humans and animals. Animal models are crucial for studying virus pathogenesis, vaccine development, and drug testing.
Ziqing Jia, Dong Zhang, Lin Zhu, Jing Xue   +3 more
wiley   +1 more source

G-quadruplex-interacting compounds alter latent DNA replication and episomal persistence of KSHV

Nucleic Acids Research, 2016
Kaposi's sarcoma associated herpesvirus (KSHV) establishes life-long latent infection by persisting as an extra-chromosomal episome in the infected cells and by maintaining its genome in dividing cells.
Advaitha Madireddy, Pravinkumar Purushothaman, Christopher P. Loosbroock, E. Robertson, C. Schildkraut, S. Verma   +5 more
semanticscholar   +1 more source

Primary Effusion Lymphoma Prognostic Score (PEL‐PS): A Validated International Prognostic Score in HIV‐Associated Primary Effusion Lymphoma

American Journal of Hematology, Volume 100, Issue 3, Page 393-401, March 2025.
ABSTRACT Primary effusion lymphoma (PEL) is an HIV‐associated B‐cell non‐Hodgkin lymphoma (NHL) caused by Kaposi sarcoma herpesvirus (KSHV). There is no validated prognostic model in PEL, and prognosis is thought to be poor compared to other HIV‐associated NHL.
Kathryn Lurain, Ramya Ramaswami, Eric Oksenhendler, David Boutboul, Alessia Dalla Pria, Lara Ulrich, Krithika Shanmugasundaram, Thomas S. Uldrick, Mark Bower, Robert Yarchoan, Laurence Gérard, Seth M. Steinberg   +11 more
wiley   +1 more source

Heterogeneity and breadth of host antibody response to KSHV infection demonstrated by systematic analysis of the KSHV proteome.

PLoS Pathogens, 2014
The Kaposi sarcoma associated herpesvirus (KSHV) genome encodes more than 85 open reading frames (ORFs). Serological evaluation of KSHV infection now generally relies on reactivity to just one latent and/or one lytic protein (commonly ORF73 and K8.1 ...
Nazzarena Labo, Wendell Miley, Vickie Marshall, William Gillette, Dominic Esposito, Matthew Bess, Alexandra Turano, Thomas Uldrick, Mark N Polizzotto, Kathleen M Wyvill, Rachel Bagni, Robert Yarchoan, Denise Whitby   +12 more
doaj   +1 more source

Integrated systems biology analysis of KSHV latent infection reveals viral induction and reliance on peroxisome mediated lipid metabolism

PLoS Pathogens, 2017
Kaposi’s Sarcoma associated Herpesvirus (KSHV), an oncogenic, human gamma-herpesvirus, is the etiological agent of Kaposi’s Sarcoma the most common tumor of AIDS patients world-wide.
Z. Sychev, Alex Hu, Terri A DiMaio, A. Gitter, N. Camp, William Stafford Noble, Alejandro Wolf-Yadlin, M. Lagunoff   +7 more
semanticscholar   +1 more source

Hsp70 Isoforms Are Essential for the Formation of Kaposi's Sarcoma-Associated Herpesvirus Replication and Transcription Compartments.

PLoS Pathogens, 2015
Kaposi's sarcoma-associated herpesvirus (KSHV) is an oncogenic herpesvirus associated with various AIDS-related malignancies. Like other herpesviruses, multiple processes required for KSHV lytic replication, including viral transcription, viral DNA ...
Belinda Baquero-Pérez, Adrian Whitehouse   +1 more
doaj   +1 more source

Kaposi Sarcoma Herpesvirus (KSHV) Latency-Associated Nuclear Antigen (LANA) recruits components of the MRN (Mre11-Rad50-NBS1) repair complex to modulate an innate immune signaling pathway and viral latency

PLoS Pathogens, 2017
Kaposi Sarcoma Herpesvirus (KSHV), a γ2-herpesvirus and class 1 carcinogen, is responsible for at least three human malignancies: Kaposi Sarcoma (KS), Primary Effusion Lymphoma (PEL) and Multicentric Castleman’s Disease (MCD).
Giuseppe Mariggiò, S. Koch, Guigen Zhang, Magdalena Weidner-Glunde, J. Rückert, S. Kati, S. Santag, T. Schulz   +7 more
semanticscholar   +1 more source

KSHV LANA's expanding bag of tricks

Blood, 2008
In this issue of Blood, Di Bartolo and colleagues report that KSHV targets the TGF-β signaling pathway in latently infected tumor cells.
Kenneth M. Kaye, Andrew J. Barbera
openaire   +3 more sources

BET-Inhibitors Disrupt Rad21-Dependent Conformational Control of KSHV Latency

PLoS Pathogens, 2017
Kaposi’s Sarcoma-associated Herpesvirus (KSHV) establishes stable latent infection in B-lymphocytes and pleural effusion lymphomas (PELs). During latency, the viral genome persists as an epigenetically constrained episome with restricted gene expression ...
Horng-Shen Chen, A. De Leo, Zhuo Wang, A. Kerekovic, R. Hills, P. Lieberman   +5 more
semanticscholar   +1 more source