Results 101 to 110 of about 69,810 (276)

FK 506 pre-treatment is associated with reduced levels of tumor necrosis factor and interleukin 6 following hepatic ischemia/reperfusion [PDF]

, 1993
Using a rat model, the effect of pre-treatment with FK 506 on hepatic ischemia/reperfusion injury was investigated. All control animals died within 72 h of the ischemia/reperfusion injury.
Aarden, Billiau, Camussi, Chollet-Martin, Colletti, Colletti, Craig J. McClain, David H. Van Thiel, Farber, Ferrante, Fischer, Francavilla, Francavilla, Gamble, Gauldie, Giorgio M. Zetti, Hajjar, Harding, Hayashi, Hishinuma, Honchel, Howard, Jirik, Judith S. Gavaler, Kahan, Kahn, Kawakani, Kim, Kim, Kino, Kishimoto, Kishimoto, Kramer, Lotz, Magilavy, Mahmoud F. Sakr, Makowka, Makowka, Matuschak, Maury, Mazzaferro, Meer, Miyahara, Mizel, Nagakawa, Nagakawa, Nawroth, Nordan, Nordan, Pennica, Perez-Tamayo, Pohlman, Sakai, Sakr, Shalaby, Shaw, Siekierka, Starzl, Starzl, Strieter, Takahashi, Thomas E. Starzl, Van Snick, Wankowicz, Yushimira   +64 more
core   +1 more source

Incorporation of Novel Synthetic Glycolipids in Liposomal Nanoparticles Affects Opsonization and In Vivo Clearance

Angewandte Chemie International Edition, EarlyView.
We prepared five glycosylated liposomal nanoparticles (G‐LNPs) to investigate the role of glycosylation and protein corona in modulating the in vivo behavior of G‐LNPs. We show that IgG and complement C3 adsorption enhanced liposomal nanoparticle clearance, with IgG promoting subsequent C3 binding.
Yingjie Yu, Xuehan Li, Yu Gao, Shijia Tao, Xiaofei Li, Lemei Zhao, Wenshuai Han, Hao Fan, Ying Qiu, Man Wang, Luying Zhou, Xiaoyan Fang, Wenhua Yang, Haiyang Zhang, Volker Mailänder, Daniel Crespy, Katharina Landfester, Shuai Jiang, Xiangzhao Mao   +18 more
wiley   +1 more source

3D co-cultures of primary human hepatocytes and Kupffer-like cells to address innate immune responses to rAAV

Scientific Reports
Recombinant adeno-associated viruses (rAAVs) are a platform of choice for gene therapy. However, liver-directed transduction has been hindered by immune responses unpredicted in the pre-clinical models, resulting in therapy failure.
Isabella Ramella Gal, Francisca Arez, Inês P. Correia, Giacomo Domenici, Sofia Fernandes, Gabriela Silva, Inês Saldanha, Nadia Duarte, Catarina Freitas, Paula M. Alves, Udo Maier, Ana Sofia Coroadinha, François du Plessis, Catarina Brito   +13 more
doaj   +1 more source

The role of lipid and lipoprotein metabolism in non-alcoholic fatty liver disease [PDF]

, 2017
Due to the epidemic of obesity across the world, nonalcoholic fatty liver disease (NAFLD) has become one of the most prevalent chronic liver disorders in children and adolescents.
Anania, Caterina, Lavorato, Michela, Perla, Francesco Massimo, Prelati, Maurizia, Visicchio, Daniele   +4 more
core   +2 more sources

A Multifaceted Interplay Among Hemophagocytosis, Interleukin‐18, and Type I Interferon Distinguishes Still Disease From Other Autoinflammatory Diseases

Arthritis &Rheumatology, EarlyView.
Objective The unknown pathophysiology and the lack of specific features for systemic juvenile idiopathic arthritis and adult‐onset Still disease (collectively known as Still disease; SD) delay diagnosis and appropriate treatment. The goal of this study was to identify features and mechanisms that distinguish SD from other systemic autoinflammatory ...
Yvonne M. Mueller, Charlotte Girard, Harmen J. G. van de Werken, Stefan J. Erkeland, Dwin G. B. Grashof, Laurie Vaillant, Renske J. H. den Dekker, Iris van Zuijen, Sharon Veenbergen, Fanny Coffin, Eric Bindels, Yvan Jamilloux, Katerina Laskari, Vassili Soumelis, Bruno Fautrel, Cem Gabay, Peter D. Katsikis   +16 more
wiley   +1 more source

TMEM16F Expressed in Kupffer Cells Regulates Liver Inflammation and Metabolism to Protect Against Listeria Monocytogenes

Advanced Science
Infection by bacteria leads to tissue damage and inflammation, which need to be tightly controlled by host mechanisms to avoid deleterious consequences.
Jianlong Tang, Hua Song, Shimin Li, Sin Man Lam, Jieming Ping, Mengyun Yang, Na Li, Teding Chang, Ze Yu, Weixiang Liu, Yan Lu, Min Zhu, Zhaohui Tang, Zheng Liu, Yusong R. Guo, Guanghou Shui, André Veillette, Zhutian Zeng, Ning Wu   +18 more
doaj   +1 more source

Comparison of JB4 plastic resin and standard paraffin methods on student performance and student perspectives in digital histology education: A randomized controlled study

Anatomical Sciences Education, EarlyView.
Abstract This randomized controlled study compared the effectiveness of histological preparations embedded in glycol methacrylate‐based JB4 plastic resin with traditional paraffin blocks in digital histology education. A total of 297 second‐year medical students at Sivas Cumhuriyet University participated.
Zeynep Deniz Şahin İnan, Ezgi Ağadayı   +1 more
wiley   +1 more source

The role of the host—Neutrophil biology

Periodontology 2000, EarlyView., 2023
Abstract Neutrophilic polymorphonuclear leukocytes (neutrophils) are myeloid cells packed with lysosomal granules (hence also called granulocytes) that contain a formidable antimicrobial arsenal. They are terminally differentiated cells that play a critical role in acute and chronic inflammation, as well as in the resolution of inflammation and wound ...
Iain L. C. Chapple, Josefine Hirschfeld, Alpdogan Kantarci, Asaf Wilensky, Lior Shapira   +4 more
wiley   +1 more source

Kupffer cell

Citation: 'Kupffer cell' in the IUPAC Compendium of Chemical Terminology, 5th ed.; International Union of Pure and Applied Chemistry; 2025. Online version 5.0.0, 2025. 10.1351/goldbook.13367 • License: The IUPAC Gold Book is licensed under Creative Commons Attribution-ShareAlike CC BY-SA 4.0 International for individual terms.
Mark D Stringer, Seyed Ali Mirjalili
openaire   +2 more sources

A Coculture Model of Intrahepatic Islet Transplantation: Activation of Kupffer Cells by Islets and Acinar Tissue

Cell Transplantation, 2001
Clinical and experimental studies of intrahepatic islet transplantation have allowed histological and systemic observations to be made, but the location of the transplanted islets makes it difficult to assess direct effects on the cells of the liver.
Heather A. Clayton, Joanna E. Davies, Chris D. Sutton, Peter R. F. Bell, Ashley R. Dennison   +4 more
doaj   +1 more source