Extracellular CIRP promotes Kupffer cell inflammatory polarization in sepsis [PDF]
Frontiers in ImmunologyIntroductionSepsis is a life-threatening inflammatory condition caused by dysregulated host responses to infection. Extracellular cold-inducible RNA-binding protein (eCIRP) is a recently discovered damage-associated molecular pattern that causes ...
Junji Shimizu +6 more
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The role of heme in sepsis induced Kupffer cell PANoptosis and senescence [PDF]
Cell Death and DiseaseElevated heme levels, a consequence of hemolysis, are strongly associated with increased susceptibility to bacterial infections and adverse sepsis outcomes, particularly in older populations.
Tingting Li +12 more
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SLC38A4 promotes Kupffer cell phagocytosis and suppresses tumor liver metastasis [PDF]
Experimental and Molecular MedicineMetastasis is the main cause of cancer-related death. The liver is an organ with high metastatic tropism for various malignancies. Hepatic-resident macrophage Kupffer cells are the major non-parenchymal cells in the liver that phagocytize disseminated ...
Jie Li +14 more
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Drug Delivery, 2018 Because of its multifaceted anti-inflammatory and immunomodulatory effects, delivering type-I interferon to Kupffer cells has the potential to function as a novel type of therapy for the treatment of various types of hepatitis.
Yuki Minayoshi +23 more
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Research and Application of Kupffer Cell Thresholds for BSA Nanoparticles [PDF]
Molecules, 2023 Over the past decade, the dose of nanoparticles given to solid tumors has remained at a median of 0.7% of the injected dose. Most nanoparticles are trapped in a mononuclear phagocyte system (MPS), of which 85% are Kupffer cells.
Huanhuan Guo +6 more
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Kupffer Cell Inactivation Alters Endothelial Cell Adhesion Molecules in Cecal Ligation and Puncture-Induced Sepsis [PDF]
BiomoleculesThe activation of Kupffer cells, resident macrophages in the liver, is closely associated with the inflammatory response during sepsis, which leads to multiple-organ failure.
Sumeet Manandhar +3 more
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Discrimination of cell-intrinsic and environment-dependent effects of natural genetic variation on Kupffer cell epigenomes and transcriptomes [PDF]
Nature Immunology, 2023 Hunter Bennett +2 more
exaly +2 more sources
Epigenetic Regulation of Kupffer Cell Function in Health and Disease
Frontiers in Immunology, 2021 Kupffer cells, the resident macrophages of the liver, comprise the largest pool of tissue macrophages in the body. Within the liver sinusoids Kupffer cells perform functions common across many tissue macrophages including response to tissue damage and ...
Hunter Bennett +5 more
doaj +1 more source
Pro-inflammatory activated Kupffer cells by lipids induce hepatic NKT cells deficiency through activation-induced cell death. [PDF]
PLoS ONE, 2013 BACKGROUND: Dietary lipids play an important role in the progression of non-alcoholic fatty liver disease (NAFLD) through alternation of liver innate immune response.
Tongfang Tang +4 more
doaj +1 more source
Frontiers in Immunology, 2022 Kupffer cells are the primary liver resident immune cell responsible for the liver firewall function, including clearance of bacterial infection from the circulation, as they are strategically positioned inside the liver sinusoid with intimate contact ...
Mateus Eustáquio Lopes +10 more
doaj +1 more source