Results 11 to 20 of about 69,810 (276)
Stellate cells, hepatocytes, and endothelial cells imprint the Kupffer cell identity on monocytes colonizing the liver macrophage niche [PDF]
Immunity, 2019 Macrophages are strongly adapted to their tissue of residence. Yet, little is known about the cell-cell interactions that imprint the tissue-specific identities of macrophages in their respective niches. Using conditional depletion of liver Kupffer cells,
Beschin, Alain +22 more
core +3 more sources
Preparation of Zoledronate liposome and its impact on apoptosis of Kupffer cells in rat liver [PDF]
Acta Cirúrgica Brasileira, 2018 Purpose: To establish a method for the preparation of zoledronate liposome and to observe its effect on inducing the apoptosis of rat liver Kupffer cells.
Qiao-Hong Zhao +7 more
doaj +1 more source
Ecotoxicology and Environmental Safety, 2022 We have previously shown trichloroethylene (TCE) induced immune liver injury, and TNF-α/TNFR1 pathway as a probably mechanism underlying the immune damage, but the pathogenic mechanism is still unclear. The study aims to investigate whether TNF-α and its
Jia-xiang Zhang +7 more
doaj +1 more source
Discrimination of cell-intrinsic and environment-dependent effects of natural genetic variation on Kupffer cell epigenomes and transcriptomes. [PDF]
Nat Immunol, 2023 Bennett H +14 more
europepmc +2 more sources
Elucidating Spatially-Resolved Changes in Host Signaling During Plasmodium Liver-Stage Infection
Frontiers in Cellular and Infection Microbiology, 2022 Upon transmission to the human host, Plasmodium sporozoites exit the skin, are taken up by the blood stream, and then travel to the liver where they infect and significantly modify a single hepatocyte.
Elizabeth K. K. Glennon +9 more
doaj +1 more source
Injurious effects of ethanol on rat Kupffer cells. [PDF]
, 1986 The effects of ethanol on rat Kupffer cells were studied functionally and morphologically. Eight g ethanol per kg body weight per day was intragastrically administered to rats for 7 days.
Itoshima, Tatsuya +2 more
core +1 more source
Biomedicines, 2022 Kupffer cells are maintained via self-renewal in specific microenvironmental niches, primarily the liver sinusoidal endothelial cells (LSECs). In this study, we propagated tissue-resident macrophages (Mø) from mouse liver using mixed culture with hepatic
Sho Kohara, Kazushige Ogawa
doaj +1 more source
Immunotherapy in hepatocellular carcinoma: the complex interface between inflammation, fibrosis, and the immune response. [PDF]
, 2019 Hepatocellular carcinoma (HCC) is the third leading cause of cancer deaths worldwide and confers a poor prognosis. Beyond standard systemic therapy with multikinase inhibitors, recent studies demonstrate the potential for robust and durable responses ...
Fong, Lawrence +2 more
core +2 more sources
Life Science Alliance, 2018 This study reports on the identification of two Plasmodium GAPDH epitope peptides that are responsible for sporozoite–Kupffer cell interaction and act as antigens against malaria infection.
Sung-Jae Cha +2 more
doaj +1 more source
Cellular and Molecular Gastroenterology and Hepatology, 2020 Background & Aims: Toll-like receptor 2 (TLR2) and TLR3 regulate hepatic immunity under pathological conditions, but their functions and potential drug targets in alcoholic liver disease (ALD) remain poorly understood.
Pingping Luo +11 more
doaj +1 more source