Results 41 to 50 of about 46,673 (194)
Kupffer cell activation after no-flow ischemia versus hemorrhagic shock [PDF]
, 2002 Kupffer cell-derived oxidant stress is critical for reperfusion injury after no-flow ischemia. However, the importance of Kupffer cells as source of reactive oxygen formation is unclear in a hemorrhagic shock model.
Farhood, Anwar, Jaeschke, Hartmut
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Prevention of Kupffer cell-induced oxidant injury in rat liver by atrial natriuretic peptide [PDF]
, 1999 The generation of reactive oxygen species (ROS) by activated Kupffer cells contributes to liver injury following liver preservation, shock, or endotoxemia. Pharmacological interventions to protect liver cells against this inflammatory response of Kupffer
Angelika M. Vollmar +4 more
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Kupffer cells prevent pancreatic ductal adenocarcinoma metastasis to the liver in mice
Nature Communications, 2023 Although macrophages contribute to cancer cell dissemination, immune evasion, and metastatic outgrowth, they have also been reported to coordinate tumor-specific immune responses.
Stacy K. Thomas +14 more
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Endothelial Specific HSPA12B Plays a Critical Role in Maintaining Hepatic Kupffer Cell Bacterial Clearance [PDF]
, 2022 Sepsis is defined as a life-threatening disease that is characterized by multiple organ dysfunction caused by an uncontrolled host response to an infection. Hepatic dysfunction contributes to sepsis-induced mortality and morbidity.
Adams, Joseph +3 more
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iScience, 2021 Summary: Nonalcoholic fatty liver disease (NAFLD) is a global health-care problem with limited therapeutic options. To obtain a cellular resolution of pathogenesis, 82,168 single-cell transcriptomes (scRNA-seq) across different NAFLD stages were profiled,
Qi Su +12 more
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, 2014 (A) Scoring for the size and foamy appearance of Kupffer cells using CD68 staining. (B) Scoring for the size and foamy appearance of Kupffer cells using HE staining. A score ranging from 0–3 was given by an experienced pathologist.
Veerle Bieghs (186620) +15 more
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Inhibition of nitric oxide production reverses diabetes-induced Kupffer cell activation and Klebsiella pneumonia liver translocation. [PDF]
PLoS ONE, 2017 Klebsiella pneumoniae (KP) is the most common pathogen of pyogenic liver abscess in East and Southeast Asia and diabetes mellitus (DM) is a major risk factor. The effect and mechanism of diabetes on KP liver abscess was examined in streptozotocin-induced
Shu-Han Lin +5 more
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Using imaging to study inflammatory platelet–leukocyte interactions in vivo
Platelets, 2020 In addition to their roles in hemostasis and thrombosis, platelets are now recognized as making important contributions to a wide variety of inflammatory responses.
Olivia Susanto, Michael J. Hickey
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Ecotoxicology and Environmental Safety, 2023 Aim: Triptolide (TRI) is an active diterpenoid lactone compound isolated from Tripterygium wilfordii,We focused on investigating the effect and mechanism of Triptolide (TRI) on liver injury. Methods: The toxic dose (LD50 = 100 μM) of TRI on liver Kupffer
Chenyang Han +8 more
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Kupffer cell prostaglandin E2 stimulates parenchymal cell O2 consumption: alcohol and cell-cell communication [PDF]
, 1996 Several studies have demonstrated that ethanol can increase hepatic O2 uptake (e.g., produce a hypermetabolic state); however, a complete explanation of this important phenomenon remains unclear.
M. Goto, W. Qu, Z. Zhong, R. G. Thurman
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