Kupffer cells modulate iron homeostasis in mice via regulation of hepcidin expression [PDF]
, 2007 Hepcidin, a small cationic liver derived peptide, is a master regulator of body iron homeostasis. Cytokines and iron availability have so far been identified as regulators of hepcidin expression.
Hochegger, Kathrin +16 more
core +1 more source
Upregulation of the Tim-3/galectin-9 pathway of T cell exhaustion in chronic hepatitis B virus infection. [PDF]
, 2012 The S-type lectin galectin-9 binds to the negative regulatory molecule Tim-3 on T cells and induces their apoptotic deletion or functional inactivation.
Cheng, Y +59 more
core +1 more source
Cellular and Molecular Gastroenterology and Hepatology, 2020 Background & Aims: Toll-like receptor 2 (TLR2) and TLR3 regulate hepatic immunity under pathological conditions, but their functions and potential drug targets in alcoholic liver disease (ALD) remain poorly understood.
Pingping Luo +11 more
doaj +1 more source
Kupffer cell-monocyte communication is essential for initiating murine liver progenitor cell-mediated liver regeneration [PDF]
, 2015 Liver progenitor cells (LPCs) are necessary for repair in chronic liver disease because the remaining hepatocytes cannot replicate. However, LPC numbers also correlate with disease severity and hepatocellular carcinoma risk.
Wikstrom, M. +25 more
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Effect of allyl alcohol on hepatic transporter expression: Zonal patterns of expression and role of Kupffer cell function [PDF]
, 2009 During APAP toxicity, activation of Kupffer cells is critical for protection from hepatotoxicity and up-regulation of multidrug resistance-associated protein 4 (Mrp4) in centrilobular hepatocytes.
Rooijen, N. van +7 more
core +1 more source
An intravascular immune response to Borrelia burgdorferi involves Kupffer cells and iNKT cells [PDF]
, 2010 Here we investigate the dynamics of the hepatic intravascular immune response to a pathogen relevant to invariant natural killer T cells (iNKT cells).
Strieter, R.M. +21 more
core +3 more sources
Mouse CD11b+Kupffer Cells Recruited from Bone Marrow Accelerate Liver Regeneration after Partial Hepatectomy. [PDF]
PLoS ONE, 2015 TNF and Fas/FasL are vital components, not only in hepatocyte injury, but are also required for hepatocyte regeneration. Liver F4/80+Kupffer cells are classified into two subsets; resident radio-resistant CD68+cells with phagocytic and bactericidal ...
Kiyoshi Nishiyama +7 more
doaj +1 more source
Functions of two distinct Kupffer cells in the liver
Exploration of Medicine, 2021 Tissue-resident macrophages play critically important roles in host homeostasis and pathogenesis of diseases, with the functions of phagocytosis, metabolism, and immune modulation.
Chunye Zhang, Shuai Liu, Ming Yang
doaj +1 more source
Kupffer cells and alcoholic liver disease [PDF]
, 2006 Department of Medicine. Division of Liver Diseases. Mount Sinai School of Medicine. New York, USALiver disease is a major cause of illness and death worldwide.
Nieto, Natalia +1 more
core +1 more source
Cell Transplantation, 2013 Numerous approaches to cell transplantation of the hepatic or the extrahepatic origin into liver tissue have been developed; however, the efficiency of cell transplantation remains low and liver functions are not well corrected.
Il-Hwa Hong +11 more
doaj +1 more source