Results 51 to 60 of about 46,673 (194)

Liver-Derived Signals Sequentially Reprogram Myeloid Enhancers to Initiate and Maintain Kupffer Cell Identity [PDF]

, 2019
Tissue environment plays a powerful role in establishing and maintaining the distinct phenotypes of resident macrophages, but the underlying molecular mechanisms remain poorly understood.
Spann, Nathanael J, Bennett, Hunter, Link, Verena M, Thompson, Bonne M, Ouyang, Zhengyu, Abe, Yohei, Texari, Lorane, Sakai, Mashito, Seidman, Jason S, Ego, Kaori M, Heinz, Sven, Glass, Christopher K, Troutman, Ty D, Bruni, Cassi M, Schlachetzki, Johannes CM, Vu, BaoChau T, McDonald, Jeffrey G, Nott, Alexi, Geissmann, Frederic, Deng, Zihou, Chang, Jonathan, Pasillas, Martina P   +21 more
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Role of Kupffer Cells in Driving Hepatic Inflammation and Fibrosis in HIV Infection

Frontiers in Immunology, 2020
While the interactions between HIV and various liver cell populations have been explored, the relevance of these interactions when patients are well-controlled on ART is less clear. Therefore, we focus this perspective on HIV-related alterations that may
Lumin Zhang, Meena B. Bansal
doaj   +1 more source

Prevention of Ischemia-Reperfusion Injury in the Rat Liver by Atrial Natriuretic Peptide [PDF]

, 2002
This work characterizes the protective effects of ANP preconditioning in ischemia-reperfusion injury of the isolated perfused rat liver. It was of particular interest to evaluate the influence of ANP on the mode of cell death occurring during cold ...
Gerwig, Tobias
core  

Desialylated Platelet Clearance in the Liver is a Novel Mechanism of Systemic Immunosuppression

Research, 2023
Platelets are small, versatile blood cells that are critical for hemostasis/thrombosis. Local platelet accumulation is a known contributor to proinflammation in various disease states.
June Li, Danielle Karakas, Feng Xue, Yingyu Chen, Guangheng Zhu, Yeni H. Yucel, Sonya A. MacParland, Haibo Zhang, John W. Semple, John Freedman, Qizhen Shi, Heyu Ni   +11 more
doaj   +1 more source

Interrogating in vivo Mechanisms of Kupffer Cell Transcriptional Regulation Using Natural Genetic Variation [PDF]

, 2022
Tissue macrophages are essential for the maintenance of organ homeostasis, but the cellular mechanisms specifying their phenotype are poorly understood. Here, we leverage natural genetic variation between inbred mouse strains as a tool to perturb Kupffer
Bennett, Hunter
core  

Gut-primed neutrophils activate Kupffer cells to promote hepatic injury in mouse sepsis

Nature Communications
Sepsis-induced liver injury is common, but the underlying mechanisms remain poorly understood. Given the critical role of gut-liver crosstalk in sepsis, we hypothesize that gut-trained neutrophils, migrating via the portal vein, release neutrophil ...
Atsushi Murao, Alok Jha, Takayuki Kato, Junji Shimizu, Yuichi Akama, Monowar Aziz, Ping Wang   +6 more
doaj   +1 more source

Heme oxygenase 1-mediated ferroptosis in Kupffer cells initiates liver injury during heat stroke

Acta Pharmaceutica Sinica B
With the escalating prevalence of global heat waves, heat stroke has become a prominent health concern, leading to substantial liver damage. Unlike other forms of liver injury, heat stroke-induced damage is characterized by heat cytotoxicity and ...
Ru Li, Riqing Wei, Chenxin Liu, Keying Zhang, Sixiao He, Zhifeng Liu, Junhao Huang, Youyong Tang, Qiyuan An, Ligen Lin, Lishe Gan, Liying Zhao, Xiaoming Zou, Fudi Wang, Yuan Ping, Qiang Ma   +15 more
doaj   +1 more source

Role of Kupffer cells in tolerance induction after liver transplantation

Frontiers in Cell and Developmental Biology, 2023
Currently, liver transplantation has reached a level of maturity where it is considered an effective treatment for end-stage liver disease and can significantly prolong the survival time of patients.
Weixiong Zheng, Lingxiang Yang, Shiming Jiang, Mingxiang Chen, Jinzheng Li, Zuojing Liu, Zhongjun Wu, Jianping Gong, Yong Chen   +8 more
doaj   +1 more source

Inhibition of Kupffer Cell Autophagy Abrogates Nanoparticle-Induced Liver Injury [PDF]

, 2017
The possible adverse effects of engineered nanomaterials on human health raise increasing concern as our research on nanosafety intensifies. Upon entry into a human body, whether intended for a theranostic purpose or through unintended exposure ...
Liu, Xuesheng, Bai, Li, Yiming Liu, Erwei Gu, Pengfei Wei, Yi Hu, Wen, Longping, Wei Zhou, Li Zhang, Longping Wen, Liu, Yiming, Gu, Erwei, Xuesheng Liu, Peipei Jin, Zhang, Yunjiao, Ma, Wentao, Shasha Zhu, Zhu, Shasha, Li Bai, Zhang, Li, Jun Lin, Lu, Xianfu, Yunjiao Zhang, Zhou, Wei, Zhilai Yang, Man, Na, Lin, Jun, Na Man, Wei, Pengfei, Zhang, Jiqian, Jiqian Zhang, Wentao Ma, Hu, Yi, Yang, Zhilai, Xianfu Lu, Jin, Peipei   +35 more
core   +1 more source

PD-1 blockade improves Kupffer cell bacterial clearance in acute liver injury [PDF]

, 2020
Acute liver failure (ALF) patients display systemic innate immune suppression and increased susceptibility to infections. PD-1 expression by macrophages has been associated with immune suppression during sepsis and cancer.
Thursz, Mark, Kudo, Hiromi, Mukherjee, Sujit K, Possamai, Lucia, McPhail, Mark, O'Connor, Thomas, Woollard, Kevin, Trovato, Francesca, Mawhin, Marie-Anne, Goldin, Robert, Bernsmeier, Christine, Gudd, Cathrin, Triantafyllou, Evangelos, Husbyn, Hannah, Wendon, Julia A, Khamri, Wafa, Botto, Marina, Siggins, Matthew, Charalambos, Antoniades G   +18 more
core   +1 more source