Results 161 to 170 of about 43,811 (246)

Diverse immunological roles of liver‐resident immune cells in liver diseases

Precision Medical Sciences, Volume 15, Issue 1, Page 4-17, March 2026.
Based on their origin and functional characteristics, LRICs can be classified into four categories. These cells differ in the focus of their immune functions in liver diseases, yet all exhibit the characteristic of functional bidirectionality.
Zhengyi Fan, Xinqiang Li, Peng Jiang, Dahong Teng, Jinzhen Cai   +4 more
wiley   +1 more source

Inhibitor of differentiation 3 confers the robust anti-tumor activity of Kupffer cells. [PDF]

MedComm (2020)
Ren J, Liu S, Zhang L.
europepmc   +1 more source

Remodeling the Inflammatory Microenvironment: Nanomaterial‐Based Targeted Strategies for Systemic Lupus Erythematosus and Lupus Nephritis

Small Science, Volume 6, Issue 3, March 2026.
Current treatments for severe lupus nephritis are limited by side effects due to poor drug targeting. This review explores how smart nanomaterials—like liposomes and biomimetic carriers—can precisely deliver drugs to overactive immune cells and the kidneys. These nanotherapeutics enhance efficacy, reduce toxicity, and enable combination strategies. The
Cheng Zhou, Jiayi Li, Jian Zhang, Haifeng Wang, Haitao Lu, Shunlai Shang, Wenge Li   +6 more
wiley   +1 more source

Kupffer Cells and Hepatocytes: A Key Relation in the Context of Canine Leishmaniasis. [PDF]

Microorganisms
Rodrigues A, Alexandre-Pires G, Valério-Bolas A, Nunes T, Pereira da Fonseca I, Santos-Gomes G.   +5 more
europepmc   +1 more source

Association of Haematological Parameters With TLR Genes in Healthy and Distemper‐Infected Dogs Haematology and TLRs in Distemper

Veterinary Medicine and Science, Volume 12, Issue 2, March 2026.
The distemper‐infected dogs presented with an upregulated expression of the immune recognition receptors TLR3, TLR4 and TLR9. In the distemper‐infected dogs, there was a positive correlation between the TLR1 and PWD, TLR4 and WBC, Gran and Gran%, TLR5 and HCT, TLR6 and Gran%, TLR7 and MCV and TLR7 and PDW, as well as a negative correlation between the ...
İlknur Karaca Bekdik, Fadime Daldaban, Korhan Arslan, Bilal Akyüz, Öznur Aslan   +4 more
wiley   +1 more source

Alpha Ketoglutaric Acid attenuates LPS Induced Inflammatory Response by Inhibiting the PKCε/MAPK/P65 Signaling Pathway and Inhibit Oxidative Stress in Kupffer Cells. [PDF]

Inflammation
Li Y, Kuang H, Fan G, Yang X.
europepmc   +1 more source

Oral Acute Toxicity and Genotoxicity of Heteroctenus junceus Scorpion Venom

Veterinary Medicine and Science, Volume 12, Issue 2, March 2026.
The Heteroctenus junceus scorpion venom is a very popular natural extract used in traditional medicine in Cuba. In clinically relevant experimental settings, scorpion venom does not induce general toxicity or an increase in the frequency of micronucleus formation in erythrocytes.
Alexis Díaz‐García, Jenny Laura Ruiz‐Fuentes, Sophia Mejias Medina, Nicolas Zapata Guajardo, Christian Ross Skarneo   +4 more
wiley   +1 more source

Temperature‐Gradient Transcriptomic Atlas Reveals the PPAR Signaling Pathway Dysfunction in Heat Stroke Induced Liver Injury

FASEB BioAdvances, Volume 8, Issue 3, March 2026.
Gradient‐ Temperature Atlas Uncovers Hepatic PPAR Metabolic Reprogramming. We present a murine heat‐stroke atlas (40°C–43°C) and identify PPAR‐linked lipid reprogramming as the primary mechanistic signature of temperature‐dependent liver injury, providing time‐resolved molecular targets for mechanism‐based therapies.
Ying Zhu, Wanlin Liu, Chunyuan Yang, Teng Ma, Mingfei Han, Jinxu Zhang, Yunping Zhu, Jie Ma   +7 more
wiley   +1 more source

Protocol for isolating CD163⁺ Kupffer cells from human liver resections. [PDF]

STAR Protoc
Roca Suarez AA, Plissonnier ML, Michelet M, Dubois A, Heintz S, Saez-Palma M, Delphin M, Bordes I, Molle J, Diederichs A, Rodà M, Combe E, Mougené L, Giraud G, Grand X, Rivoire M, Levrero M, Testoni B, Zoulim F.   +18 more
europepmc   +1 more source