Results 171 to 180 of about 43,811 (246)

Detection of Fungal Translocation in Patients With Alcohol Use Disorder Using a Real‐Time PCR Assay

APMIS, Volume 134, Issue 3, March 2026.
ABSTRACT Gut microbiota plays a key role in triggering various diseases. However, translocation studies focus on bacteria, neglecting fungal elements, while fungi seem also involved in triggering various diseases. Aim of this study was to assess whether fungal elements were able to translocate in patients with AUD (alcohol use disorder) and to verify ...
Nathalie Pansu, Pascal Drakulovski, Donika Krasteva, Virginie Bellet, Jean‐Philippe Lavigne, Catherine Dunyach‐Remy, Florian Salipante, Alex Yahiaoui‐Martinez, Hélène Donnadieu‐Rigole, Sébastien Bertout   +9 more
wiley   +1 more source

Gram-negative bacteria-driven increase of cytosolic phospholipase A2 leads to activation of Kupffer cells. [PDF]

Cell Mol Life Sci
Lin H, Wieser A, Zhang J, Regel I, Nieß H, Mayerle J, Gerbes AL, Liu S, Steib CJ.   +8 more
europepmc   +1 more source

Bacterial Extracellular Vesicles in the Pathogenesis and Treatment of Liver Diseases

Journal of Gastroenterology and Hepatology, Volume 41, Issue 3, Page 880-894, March 2026.
Liver diseases are a major global health challenge, with current treatments inadequate. This review highlights the role of bacterial extracellular vesicles in liver inflammation, fibrosis, and metabolism. We also explore these from commensals and probiotics, their protective effects, and discuss research challenges and future therapeutic potential ...
Yakun Li, Jia Li, Robin P. F. Dullaart, Han Moshage   +3 more
wiley   +1 more source

Alternations in inflammatory macrophage niche drive phenotypic and functional plasticity of Kupffer cells. [PDF]

Nat Commun
Huang HY, Chen YZ, Zhao C, Zheng XN, Yu K, Yue JX, Ju HQ, Shi YX, Tian L.   +8 more
europepmc   +1 more source

CD36 and Its Role in Obesity

Obesity Reviews, Volume 27, Issue 3, March 2026.
ABSTRACT Obesity is understood as a condition driven by interactions between genetics and environmental factors. The role of CD36 in the regulation of lipid metabolism and ectopic fat accumulation emerges as a key area of interest. This review presents CD36 not only as a crucial facilitator of fatty acid uptake but also as a regulator of how and where ...
Nahuel Garcia, Maiken Mellergaard, Carlos Salomon, Pilar Sepulveda, Peter Kristensen, Aase Handberg   +5 more
wiley   +1 more source

RNase T2 deficiency promotes TLR13-dependent replenishment of tissue-protective Kupffer cells. [PDF]

J Exp Med
Sato R, Liu K, Shibata T, Hoshino K, Yamaguchi K, Miyazaki T, Hiranuma R, Fukui R, Motoi Y, Fukuda-Ohta Y, Zhang Y, Reuter T, Ishida Y, Kondo T, Chiba T, Asahara H, Taoka M, Yamauchi Y, Isobe T, Kaisho T, Furukawa Y, Latz E, Nakatani K, Izumi Y, Nie Y, Taniguchi H, Miyake K.   +26 more
europepmc   +1 more source

Expression of Human Thrombomodulin Prevents Early Thrombocytopenia and Thrombotic Microangiopathy in Pig‐to‐Nonhuman Primate Orthotopic Liver Xenotransplantation

Xenotransplantation, Volume 33, Issue 2, March/April 2026.
Abstract Background Severe thrombocytopenia and coagulation dysregulation remain major barriers to survival in pig‐to‐primate liver xenotransplantation models. Methods Porcine livers with five genetic modifications (GTKO, CMAHKO, β4GalNT2KO, hCD55, and hTBM) were orthotopically transplanted into four Tibetan macaques under two conventional ...
Zhongqiang Zhang, Ting Li, Qiang Li, Bin Xie, Xinger Zhao, Jianbin Wang, Yaxun Huang, Jing Luo, Shali Wen, Yinchun Zhou, Yong Deng, Yanfang Lu, Yanyan Jiang, Jiequn Li, David K. C. Cooper, Dengke Pan, Zhongzhou Si, Haizhi Qi   +17 more
wiley   +1 more source

Loss of embryonically-derived Kupffer cells during hypercholesterolemia accelerates atherosclerosis development. [PDF]

Nat Commun
Fima R, Dussaud S, Benbida C, Blanchet M, Lanthiez F, Poupel L, Brambilla C, Gélineau A, Dessena M, Blanc M, Lerévérend C, Moreau M, Boissonnas A, Gautier EL, Huby T.   +14 more
europepmc   +1 more source

8-Methoxybicolosin C from <i>Lespedeza bicolor</i> Attenuates Inflammation and Oxidative Stress via Nrf2/HO-1 and NF-κB/MAPK Pathways in Lipopolysaccharide-Induced Mouse Kupffer Cells. [PDF]

J Microbiol Biotechnol
Cho YC, Yao L, Lee DY, Li X, Yoo G, Choi SY, Cho N, Park SJ, Yoon S, Lim JS.   +9 more
europepmc   +1 more source

CD4⁺ T cells license Kupffer cells to reverse CD8⁺ T cell dysfunction induced by hepatocellular priming. [PDF]

Nat Immunol
Venzin V, Beccaria CG, Perucchini C, Delfino P, Bono EB, Giustini L, Moalli F, Grillo M, Fumagalli V, Laura C, Di Lucia P, Reinhard K, Petschenka J, Omokoko TA, Celant A, Ottolini S, Kawashima K, Ravà M, De Giovanni M, Inverso D, Kuka M, Kennedy PTF, Guilliams M, Casorati G, Pedica F, Ponzoni M, Şahin U, Le Bert N, Bertoletti A, Vascotto F, Guidotti LG, Iannacone M.   +31 more
europepmc   +1 more source