Results 71 to 80 of about 43,811 (246)

Hepatic cholesterol crystals and crown-like structures distinguish NASH from simple steatosis[S]

Journal of Lipid Research, 2013
We sought to determine whether hepatic cholesterol crystals are present in patients or mice with nonalcoholic fatty liver disease/nonalcoholic steatohepatitis (NASH), and whether their presence or distribution correlates with the presence of NASH as ...
George N. Ioannou, W. Geoffrey Haigh, David Thorning, Christopher Savard   +3 more
doaj   +1 more source

Commonalities of platelet dysfunction in heart failure with preserved ejection fraction and underlying comorbidities

ESC Heart Failure, Volume 12, Issue 2, Page 1013-1028, April 2025.
Abstract Heart failure with preserved ejection fraction (HFpEF) is characterized by a lack of a specific targeted treatment and a complex, partially unexplored pathophysiology. Common comorbidities associated with HFpEF are hypertension, atrial fibrillation, obesity and diabetes.
Giorgia D'Italia, Blanche Schroen, Judith M.E.M. Cosemans   +2 more
wiley   +1 more source

Sex-Related Liver Injury Due to Alcohol Involves Activation of Kupffer Cells by Endotoxin

Canadian Journal of Gastroenterology, 2000
Females have a greater susceptibility to ethanol-induced liver injury than males. Females who drink ethanol regularly and have been overweight for 10 years or more are at greater risk for both hepatitis and cirrhosis than males, and females develop ...
Ronald G Thurman
doaj   +1 more source

Microengineering the Liver: Strategies for Constructing Functional Liver‐on‐a‐Chip Devices

Exploration, EarlyView.
This review summarizes recent advances in liver‐on‐a‐chip (LOC) technologies, including fabrication strategies and functional integration approaches, and discusses their promising applications in drug screening and related biomedical fields. ABSTRACT Reliable in vitro liver models are indispensable for researching liver diseases and developing ...
Jie Wang, Ziwei Liang, Jiapu Wang, Zongyi Li, Shaojie Wang, Yan Wei, Xin Xie, Di Huang   +7 more
wiley   +1 more source

Kupffer cell

Citation: 'Kupffer cell' in the IUPAC Compendium of Chemical Terminology, 5th ed.; International Union of Pure and Applied Chemistry; 2025. Online version 5.0.0, 2025. 10.1351/goldbook.13367 • License: The IUPAC Gold Book is licensed under Creative Commons Attribution-ShareAlike CC BY-SA 4.0 International for individual terms.
Mark D Stringer, Seyed Ali Mirjalili
openaire   +2 more sources

Kupffer Cells [PDF]

The American Journal of Pathology, 2020
Elise Slevin, Leonardo Baiocchi, Nan Wu, Burcin Ekser, Keisaku Sato, Emily Lin, Ludovica Ceci, Lixian Chen, Sugeily R. Lorenzo, Wenjuan Xu, Konstantina Kyritsi, Victoria Meadows, Tianhao Zhou, Debiyoti Kundu, Yuyan Han, Lindsey Kennedy, Shannon Glaser, Heather Francis, Gianfranco Alpini, Fanyin Meng   +19 more
openaire   +2 more sources

Development of Kupffer cell targeting type-I interferon for the treatment of hepatitis via inducing anti-inflammatory and immunomodulatory actions

Drug Delivery, 2018
Because of its multifaceted anti-inflammatory and immunomodulatory effects, delivering type-I interferon to Kupffer cells has the potential to function as a novel type of therapy for the treatment of various types of hepatitis.
Yuki Minayoshi, Hitoshi Maeda, Hiroki Yanagisawa, Keisuke Hamasaki, Yuki Mizuta, Kento Nishida, Ryo Kinoshita, Yuki Enoki, Tadasi Imafuku, Victor Tuan Giam Chuang, Tomoaki Koga, Yukio Fujiwara, Motohiro Takeya, Kayoko Sonoda, Tomohiko Wakayama, Kazuaki Taguchi, Yu Ishima, Tatsuhiro Ishida, Yasuko Iwakiri, Motohiko Tanaka, Yutaka Sasaki, Hiroshi Watanabe, Masaki Otagiri, Toru Maruyama   +23 more
doaj   +1 more source

Induction of Th1Immune responses following laser ablation in a murine model of colorectal liver metastases

Journal of Translational Medicine, 2011
Background Preliminary experimental studies have suggested that the in situ destruction of tumor tissue by local laser ablation (LA) may also stimulate host immunity against cancer.
Muralidharan Vijayaragavan, Nikfarjam Mehrdad, Malcontenti-Wilson Caterina, Fifis Theodora, Lin Wen, Nguyen Linh, Christophi Christopher   +6 more
doaj   +1 more source

Antimicrobial properties of Kupffer cells [PDF]

Infection and Immunity, 1988
To characterize the antimicrobial activities of Kupffer cells, I harvested macrophages from livers with a technique involving perfusion with collagenase and DNase. Ninety-nine percent of glass-adherent cells had typical macrophage morphology, 99% were esterase positive, and 60% phagocytosed opsonized zymosan when challenged with four particles per ...
openaire   +2 more sources

3D co-cultures of primary human hepatocytes and Kupffer-like cells to address innate immune responses to rAAV

Scientific Reports
Recombinant adeno-associated viruses (rAAVs) are a platform of choice for gene therapy. However, liver-directed transduction has been hindered by immune responses unpredicted in the pre-clinical models, resulting in therapy failure.
Isabella Ramella Gal, Francisca Arez, Inês P. Correia, Giacomo Domenici, Sofia Fernandes, Gabriela Silva, Inês Saldanha, Nadia Duarte, Catarina Freitas, Paula M. Alves, Udo Maier, Ana Sofia Coroadinha, François du Plessis, Catarina Brito   +13 more
doaj   +1 more source