Results 121 to 130 of about 2,282 (189)

Cholesterol and Cholesterol-Derived Molecules Differentially Modulate Neuronal Kv7.2/7.3 Channels. [PDF]

Arch Pharm (Weinheim)
Karabatak E, Nematswerani R, Meiritz V, Rychlik N, Seebohm G, Glorius F, Budde T.   +6 more
europepmc   +1 more source

Discovery of Novel Bicyclic Pyrazole Amides as Potent Neuronal K_V7 Potassium Channel Openers with Strong Preclinical Antiseizure Activity. [PDF]

ACS Med Chem Lett
Sun S, Jia Q, Bankar G, Burford KN, Christabel J, Clement HA, de Boer G, Feng Z, Hambira CM, Jackson SK, Khakh K, Kwan R, Lee S, Li J, Lindgren A, Mezeyova J, Sabbatini J, Urrutia A, Charifson P, Clark MP, Wesolowski SS, Johnson JP, Empfield JR, Dehnhardt CM, Dean R.   +24 more
europepmc   +1 more source

Assessment of gabapentin efficacy in patients with KCNQ2-developmental epileptic encephalopathy. [PDF]

Sci Rep
Xiong J, You X, Li H, Chen C, Duan H, Chen S, Cao X, He F, Fei Y, Xiao Z, Peng J.   +10 more
europepmc   +1 more source

Temporal multi-omic exploration of the ventral tegmental area in chronic pain and passive coping behaviors. [PDF]

iScience
Diezel CC, Majuta LA, Bahramnejad E, Karlage KL, Partin JL, Barbour SMD, Peterson IL, Flowers M, von Hippel ST, Haveman R, Villarroel E, Villarroel I, Langlais PR, Largent-Milnes TM, Vanderah TW, Riegel AC.   +15 more
europepmc   +1 more source

K_V7 channel activation inhibits human and murine myometrium contractility and delays delivery in a mouse model of preterm birth. [PDF]

Commun Med (Lond)
Mansour YT, Mistry HD, Chin-Smith EC, Zaleska MK, Sekulich DC, Herington JL, Reese J, Patel R, Aaronson PI, Slater DM, England SK, Greenwood IA, Johnson MR, Taylor PD, Tribe RM.   +14 more
europepmc   +1 more source

Kcnq2 R213 knock-in mice reveal variant- and region-specific mechanisms underlying self-limited familial neonatal-infantile epilepsy and early infantile developmental and epileptic encephalopathy. [PDF]

Acta Neuropathol Commun
Nishijo T, Hamada N, Suliman-Lavie R, Tabata H, Ito H, Iwamoto I, Shifman S, Nagata KI.   +7 more
europepmc   +1 more source

Cannabidiol inhibits both human K_V7.1 and K_V7.1/KCNE1 channels through distinct sites. [PDF]

Acta Pharmacol Sin
Kusay AS, Pökl M, Hiniesto-Iñigo I, Sridhar A, Delemotte L, Liin SI.   +5 more
europepmc   +1 more source

Calmodulin assists during co-translational folding of the K_V7.2 channel calcium responsive domain. [PDF]

Protein Sci
Muguruza-Montero A, Tait JR, M-Alicante S, Metola A, Nuñez E, Urrutia J, Sunderlíková V, Katranidis A, von Heijne G, Tans SJ, Villarroel A.   +10 more
europepmc   +1 more source

Activating Muscarinic Receptor Signaling in Intrapancreatic Neurons Is Required for Parasympathetic Cholinergic Control of Pancreatic Cell Function. [PDF]

Diabetes
Levi NJ, Tamayo Garcia A, Sokolov M, Barro-Soria R, Caicedo A.   +4 more
europepmc   +1 more source

XE991 Reverses Enhanced Short-Term Plasticity in Rat Epileptic CA1. [PDF]

Brain Sci
Schnell E, Müller S, Köhling R, Kirschstein T.   +3 more
europepmc   +1 more source