Results 111 to 120 of about 2,282 (189)

Polymodal K+ channel modulation contributes to dual analgesic and anti-inflammatory actions of traditional botanical medicines

Communications Biology
Pain and inflammation contribute immeasurably to reduced quality of life, yet modern analgesic and anti-inflammatory therapeutics can cause dependence and side effects.
Rían W. Manville, Ryan F. Yoshimura, Andriy V. Yeromin, Derk Hogenkamp, Jennifer van der Horst, Angel Zavala, Sonia Chinedu, Grey Arena, Emma Lasky, Mark Fisher, Christopher R. Tracy, Shivashankar Othy, Thomas A. Jepps, Michael D. Cahalan, Geoffrey W. Abbott   +14 more
doaj   +1 more source

Molecular determinants of Kv7.2 surface expression

, 2014
El objetivo de esta tesis ha sido esclarecer las bases moleculares de la expresión en membrana de los canales M neuronales, crucial para una mejor comprensión de su funcionamiento. La densidad de canales en superficie se ajusta mediante el control de las rutas endocíticas y secretoras.
openaire   +1 more source

The Novel KV7.2/KV7.3 Channel Opener ICA-069673 Reveals Subtype-Specific Functional Roles in Guinea Pig Detrusor Smooth Muscle Excitability and Contractility [PDF]

, 2015
The physiologic roles of voltage-gated KV7 channel subtypes (KV7.1–KV7.5) in detrusor smooth muscle (DSM) are poorly understood. Here, we sought to elucidate the functional roles of KV7.2/KV7.3 channels in guinea pig DSM excitability and contractility ...
John Malysz, Aaron Provence, Georgi V. Petkov   +2 more
core  

Targeting the voltage sensor of Kv7.2 voltage-gated K ⁺ channels with a new gating-modifier

, 2010
The pore and gate regions of voltage-gated cation channels have been often targeted with drugs acting as channel modulators. In contrast, the voltage-sensing domain (VSD) was practically not exploited for therapeutic purposes, although it is
Nir Ben-Tal, Yoni Haitin, Polina Kornilov, Liora Shamgar, Liat Pell, Orit Gourgy-Hacohen, Bernard Attali, Asher Peretz, Yana Gofman, Eti Patrich   +9 more
core   +1 more source

Effect of (S)-2 on the deactivation kinetics of Kv7.2 and Kv7.4.

, 2013
Normalized tail current traces for Kv7.2 (A) and Kv7.4 (E) obtained at the indicated potentials in the absence and presence of (S)-2 illustrating the pronounced effect of the compound on the deactivation kinetics.
Nicole Schmitt (368849), Sigrid Marie Blom (368847), Henrik Sindal Jensen (368850)   +2 more
core   +1 more source

Kv7.2 and Kv7.3 potassium channel subunits as new central regulators of blood pressure [PDF]

Cardiovascular Research, 2022
Barrese V., Taglialatela M.
openaire   +3 more sources

Interacción de la calmodulina con los canales Kv7.2 utilizando la técnica FRET: Estudios preliminares. [PDF]

, 2015
En este trabajo se realiza un estudio preliminar con el objetivo de observar las interacciones entre la calmodulina y los canales Kv7.2 utilizando para ello la técnica FRET (Förster resonance energy transfer)
Otegi Arzak, Jone
core  

An electrophysiological characterizaton of Kv7.2 and Nav1.1 channel mutations in genetic epilepsy

, 2012
Most genetically determined epilepsies are caused by gene mutations in genes that encode for ion channels and receptors. Functional analysis of these protein mutants shows changes in voltage dependency and/or kinetics or a complete loss of channel function via different mechanisms.
Volkers,L., Brain, Circulatory Health, Genetica, Lindhout,D., Koeleman, Bobby, Rook, MB   +6 more
openaire   +1 more source

Voltage-sensor conformational microenvironments encode isoform-selective ion channel activation. [PDF]

Proc Natl Acad Sci U S A
Manville RW, Foglia L, Yoshimura RF, Santos DE, Yu A, Abbott GW.   +5 more
europepmc   +1 more source

Loose-patch recordings reveal differential Kv7-dependent effects on spontaneous excitatory activity in control and epileptic CA1. [PDF]

Front Neurol
Nissen EM, Kirschstein T, Bertsche A, Köhling R, Franz D.   +4 more
europepmc   +1 more source