Results 91 to 100 of about 2,282 (189)

Kv7(KCNQ)-K+-Channels Influence Total Peripheral Resistance in Female but Not Male Rats, and Hamper Catecholamine Release in Hypertensive Rats of Both Sexes

Frontiers in Physiology, 2018
K+-channels of the Kv7/KCNQ-family hyperpolarize and stabilize excitable cells such as autonomic neurons and vascular smooth muscle cells (VSMC). Kv7 may therefore play a role in blood pressure (BP) homeostasis, and prevent a high total peripheral ...
Torill Berg
doaj   +1 more source

Epilepsy: Epidemiology, Molecular Pathogenesis, and Clinical Management

MedComm, Volume 7, Issue 7, July 2026.
Epilepsy is a heterogeneous and chronically evolving brain network disorder. This review integrates epidemiological burden, psychiatric comorbidities, and cyclic seizure patterns with multiscale pathogenic mechanisms, including ion‐channel dysfunction, synaptic transmission defects, neuroinflammation, metabolic and mitochondrial dysfunction, and ...
Jian Liu, Xinyan Wu, Ting Yin, Feining Huang, Manqi Kong, Yu Yang, Zinan Liu, Jiabin Yu, Tianpeng Zhang   +8 more
wiley   +1 more source

The voltage-sensing domain of kv7.2 channels as a molecular target for epilepsy-causing mutations and anticonvulsants

Frontiers in Pharmacology, 2011
Understanding the molecular mechanisms underlying voltage-dependent gating in voltage-gated ion channels (VGICs) has been a major effort over the last decades. In recent years, changes in the gating process have emerged as common denominators for several
Francesco eMiceli, MariaVirginia eSoldovieri, Fabio Arturo Iannotti, Vincenzo eBarrese, Paolo eAmbrosino, Maria eMartire, Maria Roberta Cilio, Maurizio eTaglialatela, Maurizio eTaglialatela   +8 more
doaj   +1 more source

The impact of hyperpolarization-activated cyclic nucleotide-gated (HCN) and voltage-gated potassium KCNQ/Kv7 channels on primary microglia function

Journal of Neuroinflammation, 2020
Background Microglia are essential to maintain cell homeostasis in the healthy brain and are activated after brain injury. Upon activation, microglia polarize towards different phenotypes.
Sabine Ulrike Vay, Lea Jessica Flitsch, Monika Rabenstein, Helena Monière, Igor Jakovcevski, Pavle Andjus, Dunja Bijelic, Stefan Blaschke, Helene Luise Walter, Gereon Rudolf Fink, Michael Schroeter, Maria Adele Rueger   +11 more
doaj   +1 more source

Co-localization of TrkB receptors and Kv7.2/KCNQ2 channels in parvalbumin-positive interneurons in rat dentate gyrus.

, 2013
A. Double immunohistochemistry showing the distribution of parvalbumin-positive interneurons (green) and Kv7.2/KCNQ2 channels (red) in dentate gyrus. B.
Kimmo Jensen (423990), Jose Luis Nieto-Gonzalez (2216560)   +1 more
core   +1 more source

A basic residue in the proximal C-terminus is necessary for efficient activation of the M-channel subunit Kv7.2 by PI(4,5)P₂ [PDF]

, 2013
All Kv7 potassium channels require membrane phosphatidylinositol-4,5-bisphosphate (PI(4,5)P2) for their normal function and hence can be physiologically regulated by neurotransmitters and hormones that stimulate phosphoinositide hydrolysis.
Telezhkin, V, Stephen C. Harmer, Tinker, Andrew, Alison M. Thomas, Thomas, Alison M, Telezhkin, Vsevolod, Brown, David, Vsevolod Telezhkin, Harmer, SC, David A. Brown, Brown, DA, Tinker, A, Thomas, AM, Andrew Tinker, Harmer, Stephen C   +14 more
core   +1 more source

Lack of correlation between surface expression and currents in epileptogenic AB-calmodulin binding domain Kv7.2 potassium channel mutants

Channels, 2018
Heteromers of Kv7.2/Kv7.3 subunits constitute the main substrate of the neuronal M-current that limits neuronal hyper-excitability and firing frequency. Calmodulin (CaM) binding is essential for surface expression of Kv7 channels, and disruption of this ...
Alessandro Alaimo, Ainhoa Etxeberria, Juan Camilo Gómez-Posada, Carolina Gomis-Perez, Juncal Fernández-Orth, Covadonga Malo, Alvaro Villarroel   +6 more
doaj   +1 more source

The Natural Plant Product Rottlerin Activates Kv7.1/KCNE1 Channels

Cellular Physiology and Biochemistry, 2016
Background/Aims: Acquired as well as inherited channelopathies are disorders that are caused by altered ion channel function. A family of channels whose malfunction is associated with different channelopathies is the Kv7 K+ channel family; and ...
Veronika Matschke, Ilaria Piccini, Janina Schubert, Eva Wrobel, Florian Lang, Johann Matschke, Elsie Amedonu, Sven G. Meuth, Timo Strünker, Nathalie Strutz-Seebohm, Boris Greber, Jürgen Scherkenbeck, Guiscard Seebohm   +12 more
doaj   +1 more source

Präklinische Charakterisierung neuartiger Kv7.2/3-Kanalaktivatoren [PDF]

Das über mehr als 30 Jahre in der Europäischen Union eingesetzte Analgetikum Flupirtin wurde 2018 aufgrund schwerwiegender Sicherheitsbedenken vom Markt genommen, da der Verdacht bestand, schwere hepatotoxische Ereignisse zu verursachen.
Bartz, Frieda-Marie
core  

Concentration-dependent effects of CXB analogues on Kv7.2/7.3 expressed in HEK293 cells.

, 2013
The currents were recorded using the protocol shown at the left top. A–C, Representative traces of Kv7.2/7.3 current responding to the different concentrations of UMC, DMC and CXB were shown. The dotted line indicates the zero current level.
Xuan Zhang (56049), Hailin Zhang (48017), Jinlong Qi (287090), Haixia Gao (287091), Dongyang Huang (287093), Xiaona Du (287094), Yao Mi (287089), Li Li (14993), Fan Zhang (46132)   +8 more
core   +1 more source