Results 71 to 80 of about 2,282 (189)

Beneficial Role of Natural Polyphenols Against Epilepsy: Greasing the Wheels of Pharmacotherapy Research for Epilepsy

Food Frontiers, Volume 7, Issue 6, November 2026.
ABSTRACT Epilepsy is the most disabling neurological disease that affects all economic classes, age groups, regions, and races. Although many antiseizure drugs are approved for epilepsy treatment, they fail to work in about 30%–40% of patients. Thus, there is a great need to identify better pharmacological agents to treat epilepsy.
Janakiraman Pillai Udaiyappan, Rengasamy Balakrishnan, Manivasagam Muthukumaran Tamilarasan, Subasri Pandian   +3 more
wiley   +1 more source

Unconventional calmodulin anchoring site within the AB module of Kv7.2 channels

Journal of Cell Science, 2015
Calmodulin (CaM) binding to the AB module is critical for multiple mechanisms governing the function of Kv7.2 potassium subunits, which are one of the main components of the non-inactivating K+ M-current, a key controller of neuronal excitability. Structural analysis indicates that the CaM N-lobe engages with helix B, whereas the C-lobe anchors to the ...
Gomis-Perez C., Alaimo A., Fernandez-Orth J., Alberdi A., Aivar-Mateo P., Bernardo-Seisdedos G., Malo C., Areso P., Felipe A., Villarroel A.   +9 more
openaire   +4 more sources

Effects of KCNQ2 gene truncation on M-type Kv7 potassium currents.

PLoS ONE, 2013
The KCNQ2 gene product, Kv7.2, is a subunit of the M-channel, a low-threshold voltage-gated K(+) channel that regulates mammalian and human neuronal excitability. Spontaneous mutations one of the KCNQ2 genes cause disorders of neural excitability such as
Jon Robbins, Gayle M Passmore, Fe C Abogadie, Joanne M Reilly, David A Brown   +4 more
doaj   +1 more source

Implementation of the In Vitro Seizure Liability Assay (iLAseizure) in Drug Discovery and Development: Mechanism of Action Case Studies

Pharmacology Research &Perspectives, Volume 14, Issue 5, October 2026.
ABSTRACT Central nervous system (CNS) liabilities remain a significant cause of attrition during small molecule drug development. We previously developed the in vitro seizure liability assay (iLAseizure), a new approach methodology (NAM) comprising a human induced pluripotent stem cell neuron microelectrode array (MEA) assay coupled with a panel of ...
Kimberly Rockley, Ruth Roberts, Hannah Jennings, Karen Jones, Magali‐Anne Maizières, Michael Morton   +5 more
wiley   +1 more source

Transcriptional repression of the M channel subunit Kv7.2 in chronic nerve injury

Pain, 2011
Neuropathic pain is a severe health problem for which there is a lack of effective therapy. A frequent underlying condition of neuropathic pain is a sustained overexcitability of pain-sensing (nociceptive) sensory fibres. Therefore, the identification of mechanisms for such abnormal neuronal excitability is of utmost importance for understanding ...
Rose, Kirstin, Ooi, Lezanne, Dalle, Carine, Robertson, Brian, Wood, Ian C, Gamper, Nikita   +5 more
openaire   +4 more sources

Analyse von KV7.2 und KV7.3 Expressionsmustern in tsA201 Zellen mittels konfokaler Fluoreszenzmikroskopie

, 2022
Die Familie der spannungs-abhängigen KV7 Kalium-Ionenkanäle besteht aus den Mitgliedern KV7.1 bis KV7.5. Sie sind durch einen hyperpolarisierenden Kaliumstrom mit langsamer Öffnungskinetik und komplett fehlender Inaktivierungskinetik charakterisiert ...
Sorz, Thomas
core  

Multi‐omics analysis of ion channels expressed by chicken embryo vestibular type I and type II hair cells

Experimental Physiology, Volume 111, Issue 10, Page 4894-4914, 1 October 2026.
Abstract Balance and gaze rely on the rapid and accurate detection and signalling of head movements by vestibular type I and type II hair cells. Signal transduction and transmission involve several types of ion channels, which are acquired progressively during hair cell differentiation and whose identity is known only in part.
Giulia Cheli, Roberta Giunta, Francesca Stella, Eleonora Guidi, Umberto Laforenza, Mariarosa Polimeni, Giancarlo Russo, Francesca Borgo, Lazarevic Dejan, Sergio Masetto   +9 more
wiley   +1 more source

Effects of CXB analogues on voltage dependent activation of Kv7.2/7.3 expressed in HEK293 cells.

, 2013
The currents were recorded using the voltage protocol shown at the top of the Figure. A–D, Current traces of Kv7.2/7.3 before and after applying 100 µM CXB analogues and RTG.
Xuan Zhang (56049), Hailin Zhang (48017), Jinlong Qi (287090), Haixia Gao (287091), Dongyang Huang (287093), Xiaona Du (287094), Yao Mi (287089), Li Li (14993), Fan Zhang (46132)   +8 more
core   +1 more source

Generation of three induced pluripotent stem cell lines from a patient with KCNQ2 developmental and epileptic encephalopathy as a result of the pathogenic variant c.638C > T; p.Arg213Gln (NUIGi063-A, NUIGi063-B, NUIGi063-C) and 3 healthy controls (NUIGi064-A, NUIGi064-B, NUIGi064-C)

Stem Cell Research, 2023
KCNQ2 encodes the potassium-gated voltage channel Kv7.2, responsible for the M−current, which contributes to neuronal resting membrane potential. Pathogenic variants in KCNQ2 cause early onset epilepsies, developmental and epileptic encephalopathies.
Rachel Stewart, Cloe Gadoud, Janusz Krawczyk, Veronica McInerney, Timothy O'Brien, Sanbing Shen, Nicholas M. Allen   +6 more
doaj   +1 more source

Constitutive opening of the Kv7.2 pore activation gate causes <i>KCNQ2</i>-developmental encephalopathy. [PDF]

Proc Natl Acad Sci U S A
Pathogenic variants in KCNQ2 encoding Kv7.2 voltage-gated potassium channel subunits cause developmental encephalopathies ( KCNQ2 -encephalopathies), both with and without epilepsy.
Nappi M, Alberini G, Berselli A, Roscioni A, Soldovieri MV, Servettini I, Barrese V, Weckhuysen S, Chiu TA, Scheffer IE, Benfenati F, Maragliano L, Miceli F, Taglialatela M.   +13 more
europepmc   +5 more sources