Results 51 to 60 of about 2,282 (189)
Molecular Pain, 2018 Activation of the neuronal potassium channel Kv7.2 encoded by the KCNQ2 gene has recently been shown to be an attractive mechanism to inhibit nociceptive transmission.
Markus Valdor +9 more
doaj +1 more source
Subthreshold changes of voltage-dependent activation of the KV7.2 channel in neonatal epilepsy
Neurobiology of Disease, 2006 Benign familial neonatal convulsions (BFNC) is an epileptic disorder caused by dominant mutations in the genes KCNQ2 and KCNQ3 encoding the K+ channels KV7.2 and KV7.3. We identified two novel KCNQ2 mutations in two BFNC families.
Jessica Hunter +8 more
doaj +1 more source
Retigabine, a Kv7.2/Kv7.3-Channel Opener, Attenuates Drug-Induced Seizures in Knock-In Mice Harboring Kcnq2 Mutations. [PDF]
PLoS ONE, 2016 The hetero-tetrameric voltage-gated potassium channel Kv7.2/Kv7.3, which is encoded by KCNQ2 and KCNQ3, plays an important role in limiting network excitability in the neonatal brain.
Yukiko Ihara +6 more
doaj +1 more source
Pathogenic plasticity of Kv7.2/3 channel activity is essential for the induction of tinnitus [PDF]
Proceedings of the National Academy of Sciences, 2013 Tinnitus, the perception of phantom sound, is often a debilitating condition that affects many millions of people. Little is known, however, about the molecules that participate in the induction of tinnitus. In brain slices containing the dorsal cochlear nucleus, we reveal a tinnitus-specific increase in the spontaneous firing rate of principal neurons
Shuang, Li +2 more
openaire +2 more sources
PLoS ONE, 2012 Kv7.2 and Kv7.3 are the main components of the neuronal voltage-dependent M-current, which is a subthreshold potassium conductance that exerts an important control on neuronal excitability.
Paloma Aivar +9 more
doaj +1 more source
Elektrophysiologische Untersuchung heteromerer Kv7.2/Kv7.3-Kanäle
, 2021 Die Familie der Kv7-Kanäle stellt eine von zwölf Familien spannungsabhängiger Kaliumkanäle dar. Sie umfasst fünf Untereinheiten, Kv7.1 bis Kv7.5, die sich zu funktionstüchtigen Homo- oder Heterotetrameren zusammenlagern.
Sauer, Jakob
core
Homomeric Kv7.2 channels are inhibited by tamoxifen.
, 2013 A, Current traces of Kv7.2 in presence and absence of tamoxifen 1 µM. B, Current-voltage relationship in control (squares, n = 5) and in presence of 1µM tamoxifen (circles, n = 5). C, Kv7.2 activation curves in control (squares, n = 5) and in presence of
Ivan Arael Aréchiga-Figueroa (462495) +4 more
core +1 more source
, 2013 Inhibition of the currents recorded at 40 mV by tamoxifen 1 µM when Kv7.2/Kv7.3 and Kv7.2 R463Q channels were expressed alone compared to the effect of tamoxifen 10 µM when those channels were co-expressed with the kinase.
Ivan Arael Aréchiga-Figueroa (462495) +4 more
core +1 more source
Epileptic encephalopathy in a patientwith a novel variant in the Kv7.2 S2 transmembrane segment: Clinical, genetic, and functional features [PDF]
, 2019 Kv7.2 subunits encoded by the KCNQ2 gene provide a major contribution to the M-current (IKM), a voltage-gated K+ current crucially involved in the regulation of neuronal excitability.
Taglialatela M. +9 more
core +2 more sources
Site and Mechanism of ML252 Inhibition of Kv7 Voltage-Gated Potassium Channels
Function, 2023 Kv7 (KCNQ) voltage-gated potassium channels are critical regulators of neuronal excitability and are candidate targets for development of antiseizure medications.
Richard Kanyo +6 more
doaj +1 more source