Results 31 to 40 of about 2,282 (189)

Kv7.2 regulates the function of peripheral sensory neurons [PDF]

Journal of Comparative Neurology, 2014
ABSTRACTThe Kv7 (KCNQ) family of voltage‐gated K+ channels regulates cellular excitability. The functional role of Kv7.2 has been hampered by the lack of a viable Kcnq2‐null animal model. In this study, we generated homozygous Kcnq2‐null sensory neurons using the Cre‐Lox system; in these mice, Kv7.2 expression is absent in the peripheral sensory ...
Chih H, King, Eric, Lancaster, Daniela, Salomon, Elior, Peles, Steven S, Scherer   +4 more
openaire   +2 more sources

Calmodulin Independent Trafficking of Kv7.2 Channels [PDF]

Biophysical Journal, 2011
Helices A and B of the C-terminus of Kv7 channels constitute the calmodulin (CaM) binding site, an auxiliary protein required for exiting the endoplasmic reticulum (ER) and reaching the cell surface. CaM has also been proposed as a regulator of the biosynthesis and assembly of Kv7 subunits. Mutations in this binding site that impair association between
Villarroel, Alvaro, Gomez-Posada, Juan Camilo, Aivar, Paloma, Alaimo, Alessandro, Etxeberria, Ainhoa, Fernandez-Orth, Juncal, Areso, Pilar, Alberdi, Araitz   +7 more
openaire   +1 more source

Kv7-specific activators hyperpolarize resting membrane potential and modulate human iPSC-derived sensory neuron excitability

Frontiers in Pharmacology, 2023
Chronic pain is highly prevalent and remains a significant unmet global medical need. As part of a search for modulatory genes that confer pain resilience, we have studied two family cohorts where one individual reported much less pain than other family ...
Mark Estacion, Mark Estacion, Shujun Liu, Shujun Liu, Xiaoyang Cheng, Xiaoyang Cheng, Sulayman Dib-Hajj, Sulayman Dib-Hajj, Stephen G. Waxman, Stephen G. Waxman   +9 more
doaj   +1 more source

KV7.2 kanala: estruktura, erregulazioa eta kitzikagarritasun neuronalean duen ekintza [PDF]

, 2021
Potasio-kanalak ia zelula guztien mintzean agertzen dira eta funtzio biologiko garrantzitsuak betetzen dituzte; besteak beste, korronte elektrikoak kontrolatzen dituzte zelula kitzikagarrietan.
Núñez Viadero, Eider, Muguruza Montero, Arantza, Muguruza-Montero, Arantza, Rodriguez de Yurre, Ainhoa, Araujo Lombraña, Ariane, Urrutia, Janire, Núñez, Eider, Villarroel, Álvaro, Urrutia Iñiguez, Janire, Villarroel Muñoz, Álvaro, Araujo, Ariane   +10 more
core   +1 more source

Two KCNQ2 Encephalopathy Variants in the Calmodulin-Binding Helix A Exhibit Dominant-Negative Effects and Altered PIP2 Interaction

Frontiers in Physiology, 2020
Heterozygous missense variants in KCNQ2, which encodes the potassium channel subunit Kv7.2, are among the most common genetic causes of severe neonatal-onset epileptic encephalopathy.
Baouyen Tran, Zhi-Gang Ji, Mingxuan Xu, Tammy N. Tsuchida, Edward C. Cooper, Edward C. Cooper, Edward C. Cooper   +6 more
doaj   +1 more source

Activation of SGK1.1 Upregulates the M-current in the Presence of Epilepsy Mutations

Frontiers in Molecular Neuroscience, 2021
In the central nervous system, the M-current plays a critical role in regulating subthreshold electrical excitability of neurons, determining their firing properties and responsiveness to synaptic input.
Elva Martin-Batista, Rían W. Manville, Belinda Rivero-Pérez, David Bartolomé-Martín, Diego Alvarez de la Rosa, Geoffrey W. Abbott, Teresa Giraldez   +6 more
doaj   +1 more source

From pan-reactive KV7 channel opener to subtype selective opener/inhibitor by addition of a methyl group. [PDF]

PLoS ONE, 2014
The voltage-gated potassium channels of the KV7 family (KV7.1-5) play important roles in controlling neuronal excitability and are therefore attractive targets for treatment of CNS disorders linked to hyperexcitability.
Sigrid Marie Blom, Mario Rottländer, Jan Kehler, Christoffer Bundgaard, Nicole Schmitt, Henrik Sindal Jensen   +5 more
doaj   +1 more source

Modulation of KV7 Channel Deactivation by PI(4,5)P2

Frontiers in Pharmacology, 2020
The activity of KV7 channels critically contributes to the regulation of cellular electrical excitability in many cell types. In the central nervous system, the heteromeric KV7.2/KV7.3 channel is thought to be the chief molecular entity giving rise to M ...
Carlos A. Villalba-Galea
doaj   +1 more source

Neutralization of a unique, negatively-charged residue in the voltage sensor of KV7.2 subunits in a sporadic case of benign familial neonatal seizures

Neurobiology of Disease, 2009
Benign Familial Neonatal Seizures (BFNS) is a rare, autosomal-dominant epilepsy of the newborn caused by mutations in Kv7.2 (KCNQ2) or Kv7.3 (KCNQ3) genes encoding for neuronal potassium (K+) channel subunits.
Francesco Miceli, Maria Virginia Soldovieri, Licia Lugli, Giulia Bellini, Paolo Ambrosino, Michele Migliore, Emanuele Miraglia del Giudice, Fabrizio Ferrari, Antonio Pascotto, Maurizio Taglialatela   +9 more
doaj   +1 more source

Crosstalk between cholesterol and PIP2 in the regulation of Kv7.2/Kv7.3 channels

Biological Chemistry, 2023
Abstract It is well known that Kv7 channels activation is critically dependent on the lipid phosphatidylinositol 4,5-bisphosphate (PIP2). Furthermore, we have recently shown that Kv7.2/Kv7.3 channels are finely modulated by cholesterol. In this study, we have investigated the crosstalk between cholesterol and PIP2 in the regulation of Kv7.2/Kv7.
Mayra Delgado-Ramírez, Ana Laura López-Serrano, Sergio Sánchez-Armass, Ulises Meza, Aldo A. Rodríguez-Menchaca   +4 more
openaire   +2 more sources