Dual regulation of Kv7.2/7.3 channels by long-chain n-alcohols [PDF]
Journal of General Physiology, 2022 Normal alcohols (n-alcohols) can induce anesthetic effects by acting on neuronal ion channels. Recent studies have revealed the effects of n-alcohols on various ion channels; however, the underlying molecular mechanisms remain unclear. Here, we provide evidence that long-chain n-alcohols have dual effects on Kv7.2/7.3 channels, resulting in channel ...
Da-Jeong Jeong +2 more
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A new regulatory mechanism for Kv7.2 protein during neuropathy: enhanced transport from the soma to the axonal terminals of injured sensory neurons [PDF]
Frontiers in Cellular Neuroscience, 2015 Kv7.2 channel expression has been reported to decrease in dorsal root ganglia (DRG) following the induction of a peripheral neuropathy while other experiments show that Kv7.2 accumulates in peripheral neuromas.
Elsa eCisneros +3 more
doaj +2 more sources
An epilepsy-causing mutation leads to co-translational misfolding of the Kv7.2 channel [PDF]
BMC Biology, 2021 Background The amino acid sequence of proteins generally carries all the necessary information for acquisition of native conformations, but the vectorial nature of translation can additionally determine the folding outcome.
Janire Urrutia +11 more
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Novel functions of Calmodulin in Kv7.2 regulation and co-translational folding [PDF]
, 2023 CaM binds to the calcium responsive domain (CRD) of voltage-gated potassium channel 7.2 (Kv7.2), transmitting calcium signaling to control its pore gating. In addition, CaM affects other functions, such as trafficking to the membrane and regulation of the stability of the distal tetramerization domain.
Muguruza Montero, Arantza
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A novel role of the antidepressant paroxetine in inhibiting neuronal Kv7/M channels to enhance neuronal excitability [PDF]
Translational PsychiatryThe voltage-gated Kv7/KCNQ/M potassium channels exert inhibitory control over neuronal membrane excitability. The reduction of Kv7 channel function can improve neuronal excitability that defines the fundamental mechanism of learning and memory.
Huan Shi +4 more
doaj +2 more sources
Calcium effect on dynamics and stability of KV7.2 channel [PDF]
, 2020 345 p.
Núñez Viadero, Eider
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Discovery of E0199: A novel compound targeting both peripheral NaV and KV7 channels to alleviate neuropathic pain [PDF]
Journal of Pharmaceutical AnalysisThis research study focuses on addressing the limitations of current neuropathic pain (NP) treatments by developing a novel dual-target modulator, E0199, targeting both NaV1.7, NaV1.8, and NaV1.9 and KV7 channels, a crucial regulator in controlling NP ...
Boxuan Zhang +14 more
doaj +2 more sources
Neurodevelopmental features in KCNQ2 developmental and epileptic encephalopathy may have limited associations with KV7.2 dysfunction [PDF]
Epilepsia OpenObjective Variants in KCNQ2 encoding the voltage‐gated potassium channel KV7.2 are associated with developmental and epileptic encephalopathy (DEE) of varying severity.
Jessa S. Bidwell +4 more
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Axonal Kv7.2/7.3 channels [PDF]
Channels, 2014 Neurons target high densities of fast voltage-gated Na+ (Nav) and K+ (Kv) channels to their axonal initial segment (AISs) and nodes of Ranvier, subcellular domains governing the initiation and cond...
Kole, Maarten, Cooper, E.C.
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Frontiers in Pharmacology, 2022 Pathogenic variants in KCNQ2 encoding for Kv7.2 potassium channel subunits have been found in patients affected by widely diverging epileptic phenotypes, ranging from Self-Limiting Familial Neonatal Epilepsy (SLFNE) to severe Developmental and Epileptic ...
Ilaria Mosca +13 more
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