Results 11 to 20 of about 2,282 (189)
In Silico Methods for the Discovery of Kv7.2/7.3 Channels Modulators: A Comprehensive Review [PDF]
MoleculesThe growing interest in Kv7.2/7.3 agonists originates from the involvement of these channels in several brain hyperexcitability disorders. In particular, Kv7.2/7.3 mutants have been clearly associated with epileptic encephalopathies (DEEs) as well as ...
Claudio Stagno +6 more
doaj +5 more sources
Pivoting between calmodulin lobes triggered by calcium in the Kv7.2/calmodulin complex. [PDF]
PLoS ONE, 2014 Kv7.2 (KCNQ2) is the principal molecular component of the slow voltage gated M-channel, which strongly influences neuronal excitability. Calmodulin (CaM) binds to two intracellular C-terminal segments of Kv7.2 channels, helices A and B, and it is ...
Alessandro Alaimo +8 more
doaj +9 more sources
The Role of Kv7.2 in Neurodevelopment: Insights and Gaps in Our Understanding [PDF]
Frontiers in Physiology, 2020 Kv7.2 subunits encoded by the KCNQ2 gene constitute a critical molecular component of the M-current, a subthreshold voltage-gated potassium current controlling neuronal excitability by dampening repetitive action potential firing.
Nina Dirkx +5 more
doaj +6 more sources
Differential Regulation of PI(4,5)P2 Sensitivity of Kv7.2 and Kv7.3 Channels by Calmodulin [PDF]
Frontiers in Molecular Neuroscience, 2017 HIGHLIGHTS- Calmodulin-dependent Kv7.2 current density without the need of binding calcium.- Kv7.2 current density increase is accompanied with resistance to PI(4,5)P2 depletion.- Kv7.3 current density is insensitive to calmodulin elevation.- Kv7.3 is ...
Alvaro Villarroel +7 more
doaj +8 more sources
Calmodulin: A Multitasking Protein in Kv7.2 Potassium Channel Functions [PDF]
Biomolecules, 2018 The ubiquitous calcium transducer calmodulin (CaM) plays a pivotal role in many cellular processes, regulating a myriad of structurally different target proteins.
Alessandro Alaimo, Alvaro Villarroel
doaj +6 more sources
Tamoxifen inhibition of kv7.2/kv7.3 channels. [PDF]
PLoS ONE, 2013 KCNQ genes encode five Kv7 K(+) channel subunits (Kv7.1-Kv7.5). Four of these (Kv7.2-Kv7.5) are expressed in the nervous system. Kv7.2 and Kv7.3 are the principal molecular components of the slow voltage-gated M-channel, which regulates neuronal ...
Tania Ferrer +4 more
doaj +5 more sources
BMB Reports, 2021 Ethanol often causes critical health problems by altering the neuronal activities of the central and peripheral nerve systems. One of the cellular targets of ethanol is the plasma membrane proteins including ion channels and receptors. Recently, we reported that ethanol elevates membrane excitability in sympathetic neurons by inhibiting Kv7.2/7.3 ...
Kim, Kwon Woo, Suh, Byung-Chang
openaire +5 more sources
Accumulation of Kv7.2 channels in putative ectopic transduction zones of mice nerve-end neuromas [PDF]
Molecular Pain, 2011 Background Modulation of M-type currents has been proposed as a new strategy for the treatment of neuropathic pain due to their role in regulating neuronal excitability.
Lopez-García Jose A +2 more
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The Kv7.2/Kv7.3 Heterotetramer Assembles with a Random Subunit Arrangement [PDF]
Journal of Biological Chemistry, 2012 Voltage-gated K(+) channels composed of Kv7.2 and Kv7.3 are the predominant contributors to the M-current, which plays a key role in controlling neuronal activity. Various lines of evidence have indicated that Kv7.2 and Kv7.3 form a heteromeric channel. However, the subunit stoichiometry and arrangement within this putative heteromer are so far unknown.
Andrew P, Stewart +6 more
openaire +3 more sources
Cannabidiol counters the effects of a dominant-negative pathogenic Kv7.2 variant
iScience, 2022 Summary: Epilepsy and neurodevelopmental disorders can arise from pathogenic variants of KCNQ (Kv7) channels. A patient with developmental and epileptic encephalopathy exhibited an in-frame deletion of histidine 260 on Kv7.2. Coexpression of Kv7.2 mutant
Xiaoqin Zhan +7 more
doaj +3 more sources