Results 61 to 70 of about 2,282 (189)
, 2013 A and B, Superimposed representative Kv7.2 R463Q/Kv7.3 and Kv7.2 R463E/Kv7.3 current traces recorded in control (black) and in presence of 10 µM tamoxifen (gray).
Ivan Arael Aréchiga-Figueroa (462495) +4 more
core +1 more source
Molecular Basis for Activation to Inhibition Switching in Kv7.2 Channel Modulators
Angewandte Chemie International Edition, EarlyView.The paper describes the serendipitous discovery of chemical manipulation allowing the activator‐to‐inhibitor switching in Kv7.2 channel modulators. The molecular determinants driving this switch have been rationalized by multidisciplinary investigation encompassing synthetic and analytical chemistry, in silico methods, cryo‐EM analysis ...
Tania Ciaglia +20 more
wiley +1 more source
Frontiers in Physiology, 2020 Pathogenic variants in KCNQ2 and KCNQ3, paralogous genes encoding Kv7.2 and Kv7.3 voltage-gated K+ channel subunits, are responsible for early−onset developmental/epileptic disorders characterized by heterogeneous clinical phenotypes ranging from benign ...
Francesco Miceli +14 more
doaj +1 more source
Precision therapies for genetic epilepsies in 2025: Promises and pitfalls
Epilepsia Open, EarlyView.Abstract By targeting the underlying etiology, precision therapies offer an exciting paradigm shift to improve the stagnant outcomes of drug‐resistant epilepsies, including developmental and epileptic encephalopathies. Unlike conventional antiseizure medications (ASMs) which only treat the symptoms (seizures) but have no effect on the underlying ...
Shuyu Wang +3 more
wiley +1 more source
Tamoxifen inhibition of Kv7.2 channels is related to PIP2-channel affinity.
, 2013 A and B, Superimposed representative Kv7.2 R463Q and Kv7.2 R463E current traces recorded in control (black) and in presence of 10 µM tamoxifen (gray). Currents were evoked depolarizing the membrane to +40 mV for 3 s and then repolarizing to -60 mV.
Ivan Arael Aréchiga-Figueroa (462495) +4 more
core +1 more source
Neurobiology of Disease, 2015 Mutations in the KCNQ2 gene encoding the voltage-dependent potassium M channel Kv7.2 subunit cause either benign epilepsy or early onset epileptic encephalopathy (EOEE).
Affef Abidi +23 more
doaj +1 more source
Multiple Domains in the Kv7.3 C-Terminus Can Regulate Localization to the Axon Initial Segment
Frontiers in Cellular Neuroscience, 2020 The voltage-gated Kv7.2/Kv7.3 potassium channel is a critical regulator of neuronal excitability. It is strategically positioned at the axon initial segment (AIS) of neurons, where it effectively inhibits repetitive action potential firing.
Louise Leth Hefting +4 more
doaj +1 more source
The FEBS Journal, EarlyView.Repeated paclitaxel exposure causes long‐lasting nociceptor hyperexcitability and axonal retraction in adult sensory neurons. Using a long‐term primary nociceptor culture, we show that hyperexcitability is mediated by sequential upregulation of NaV1.8, TRPV1, TRPA1, and TRPM8 channels.
Angela Lamberti +3 more
wiley +1 more source
The Kv7.2 A–B linker is not critical for Kv7.2 mediated reduction on Kv7.3 protein levels. A.-
, 2012 Western blot of protein extracts from HEK293T cells transfected with YFP-Kv7.3 and the constructs indicated at the bottom of each column in a 1∶5 ratio. The constructs indicated at the bottom did not have a fluorescent protein tag, and were not detected ...
Manuel S. Rodríguez (124893) +9 more
core +1 more source
Maturation of spinal motor control through developmental changes in ion currents
The Journal of Physiology, EarlyView.Abstract figure legend Ion channels of spinal neurons have been shown to change during development in a wide range of species. These changes occur at specific stages of development. An important developmental process is the maturation of motor control by which the body acquires new movements or refines movements already present.
Stephanie F. Gaudreau, Tuan V. Bui
wiley +1 more source