Results 81 to 90 of about 2,282 (189)

Helix C Regulates Surface Expression of KCNQ2 (kv7.2) Channels [PDF]

Biophysical Journal, 2010
KCNQ2 (Kv7.2) subunits is one of the main subunits that give rise to the M-current, which play a prominent role in the control of neuronal excitability. Little is known regarding how the density of KCNQ2 channels at the plasma membrane is controlled. We have used the Tac membrane protein (also known as CD25/interleukin-2 receptor) as a reporter for the
Fernandez Orth, Juncal, Aivar, Paloma, Rourai Ferrer, Meritxell, Posada, Juan Camilo Gómez, Zamalloa, Teresa, Alaimo, Alessandro, Areso, Pilar, Villarroel Muñoz, Álvaro   +7 more
openaire   +1 more source

Kv7.2/Kv7.3 current inhibition by tamoxifen is voltage independent but concentration-dependent.

, 2013
A, Time course of the inhibitory effect of 1 µM tamoxifen on Kv7.2/Kv7.3 current (n = 6). B, Concentration–effect relationship for block of Kv7.2/Kv7.3 channels by tamoxifen. IC50 = 1.68 ± 0.44 µM, nH = 0.86 ± 0.12(n = 6).
Ivan Arael Aréchiga-Figueroa (462495), Martin Tristani-Firouzi (93428), Tania Ferrer (93423), Mark S. Shapiro (53587), José A. Sanchez-Chapula (462496)   +4 more
core   +1 more source

Nine patients with KCNQ2-related neonatal seizures and functional studies of two missense variants

Scientific Reports, 2023
Mutations in KCNQ2 encoding for voltage-gated K channel subunits underlying the neuronal M-current have been associated with infantile-onset epileptic disorders. The clinical spectrum ranges from self-limited neonatal seizures to epileptic encephalopathy
Suphalak Chokvithaya, Natarin Caengprasath, Aayalida Buasong, Supavadee Jantasuwan, Kanokwan Santawong, Netchanok Leela-adisorn, Siraprapa Tongkobpetch, Chupong Ittiwut, Vitchayaporn Emarach Saengow, Wuttichart Kamolvisit, Ponghatai Boonsimma, Saknan Bongsebandhu-phubhakdi, Vorasuk Shotelersuk   +12 more
doaj   +1 more source

Dorso‐Ventral and Night‐Day Regulation of Extracellular K+ Dynamics in Mouse Hippocampal Astrocytes

Glia, Volume 74, Issue 9, September 2026.
Hippocampal astrocytic K+ buffering varies by region and time. Ventral astrocytes show faster K+ accumulation due to reduced Kir4.1 function. Such regional divergence is modulated by circadian shifts in Kir4.1 and gap junction coupling. ABSTRACT Astrocytes regulate extracellular potassium (K+) through multiple mechanisms operating across distinct ...
Nariman Kiani, Kabeer Abubakar, Tin Luka Petanjek, Monique Esclapez, Anton Ivanov, Christophe Bernard   +5 more
wiley   +1 more source

Functional screen for subtype specificity of voltage sensor–targeted Kv7 potentiators

British Journal of Pharmacology, Volume 183, Issue 17, Page 5372-5388, September 2026.
Background and Purpose Voltage‐gated Kv7 (potassium channel subfamily Q [KCNQ]) potassium channels are powerful modulators of neuronal excitability. ICA‐069673 is a N‐aryl benzamide drug that targets the voltage‐sensing domain (VSD) of Kv7.2 with strong selectivity over Kv7.3 or Kv7.5, but the molecular basis of this selectivity remains poorly ...
Richard Kanyo, Thomas M. Hammond, Alice W. Wang, Caroline K. Wang, Varun Aggarwal, Shawn M. Lamothe, Harley T. Kurata   +6 more
wiley   +1 more source

A Kv7.2 mutation associated with early onset epileptic encephalopathy with suppression-burst enhances Kv7/M channel activity

, 2016
International audienceMutations in the KCNQ2 gene encoding the voltage-gated potassium channel subunit Kv7.2 cause early onset epileptic encephalopathy (EOEE).
Roubertie, Agathe, Aniksztejn, Laurent, Villard, Laurent, Devaux, Jérôme, Lacoste, Caroline, Becq, Hélène, Milh, Mathieu, Molinari, Florence, Abidi, Affef   +8 more
core   +1 more source

Astrocytes in Genetic Epilepsies: Supporting Actor or Key Player?

Journal of Neuroscience Research, Volume 104, Issue 8, August 2026.
Astrocytes contribute to the pathophysiology of acquired epilepsy. However, less is known about their contribution to genetic epilepsy syndromes which often exhibit frequent comorbidity with neurodevelopmental and psychiatric disorders. Epileptic seizures are also frequently present in neurodevelopmental disorders.
Jenny Lange, Erica Zhao, Ellie O'Connell, Olivia Gillham, Amy McTague   +4 more
wiley   +1 more source

Clicked bis-PEG-peptide conjugates for studying calmodulin-Kv7.2 channel binding [PDF]

Org. Biomol. Chem., 2014
Small bis-conjugates helix A 329–350 -PEG-triazole-PEG-helix B 508–526 (41 residues), prepared through click chemistry of PEGylated peptide derivatives, bind to CaM with nanomolar affinity, behaving as mimics of the Kv7.2 native fragment (239 residues).
Bonache M. A., Alaimo A., Malo C., Millet O., Villarroel A., Gonzalez-Muniz R.   +5 more
openaire   +4 more sources

Potency of (S)-2 on Kv7.2 and Kv7.4.

, 2013
Dose-response relationship for the effect of (S)-2 on (A) Kv7.2 (n = 6) and (B) Kv7.4 (n = 8) measured using an 86Rb-flux assay.
Nicole Schmitt (368849), Sigrid Marie Blom (368847), Henrik Sindal Jensen (368850)   +2 more
core   +1 more source

Vitamin‐Responsive Disorders: From Molecular Basis to Clinical Presentation and Therapy

Journal of Inherited Metabolic Disease, Volume 49, Issue 4, July 2026.
ABSTRACT Vitamin‐dependent cofactors are essential for numerous metabolic reactions, and defects affecting their uptake, conversion, utilisation, or regeneration constitute a heterogeneous group of inherited metabolic disorders (IMDs). Although dietary vitamin intake is sufficient to sustain coenzyme synthesis in healthy individuals, it is insufficient
Cécile Acquaviva, Yann Nadjar, Manuel Schiff, Christine Vianey‐Saban, Alain Fouilhoux, Jean‐François Benoist   +5 more
wiley   +1 more source