Results 151 to 160 of about 799,860 (178)
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Discovery of a novel Kv7 channel opener as a treatment for epilepsy
Bioorganic & Medicinal Chemistry Letters, 2015Facilitating activation, or delaying inactivation, of the native Kv7 channel reduces neuronal excitability, which may be beneficial in controlling spontaneous electrical activity during epileptic seizures. In an effort to identify a compound with such properties, the structure-activity relationship (SAR) and in vitro ADME for a series of heterocyclic ...
Jennifer E, Davoren +26 more
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Kv7 (KCNQ) channel openers induce hypothermia in the mouse
Neuroscience Letters, 2011Kv7 channels, encoded by corresponding kcnq genes, are expressed both centrally and peripherally where they serve to dampen neuronal activity. While Kv7 channel openers have shown efficacy in neurological and neuropsychiatric disease models, the impact of Kv7 channel activation on physiological endpoint markers have not been addressed in detail.
Line V, Kristensen +2 more
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Hormonal Signaling Actions on Kv7.1 (KCNQ1) Channels
Annual Review of Pharmacology and Toxicology, 2021David Fedida +2 more
exaly
Kv7.4 channels regulate potassium permeability in neuronal mitochondria
Biochemical Pharmacology, 2022Vincenzo Barrese +2 more
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The acrylamide (S)-1 differentially affects Kv7 (KCNQ) potassium channels
Neuropharmacology, 2006Morten Grunnet +2 more
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