Results 141 to 150 of about 799,860 (178)

μ-Opioid receptor signalling enhances Kir3 currents in glutamatergic preBötzinger complex neurons in mice. [PDF]

J Physiol
Kalajian EJ, Stettler MK, Smith GDC, Del Negro CA.   +3 more
europepmc   +1 more source

From Retigabine to Azetukalner: Reviving Voltage-Gated Potassium Channels for Epilepsy Therapy. [PDF]

Arch Pharm (Weinheim)
Rosendahl P, Schulig L, Link A.
europepmc   +1 more source

Discovery of Novel Bicyclic Pyrazole Amides as Potent Neuronal K_V7 Potassium Channel Openers with Strong Preclinical Antiseizure Activity. [PDF]

ACS Med Chem Lett
Sun S, Jia Q, Bankar G, Burford KN, Christabel J, Clement HA, de Boer G, Feng Z, Hambira CM, Jackson SK, Khakh K, Kwan R, Lee S, Li J, Lindgren A, Mezeyova J, Sabbatini J, Urrutia A, Charifson P, Clark MP, Wesolowski SS, Johnson JP, Empfield JR, Dehnhardt CM, Dean R.   +24 more
europepmc   +1 more source

Kv7 channels as pharmacological targets for CNS diseases

Pharmacological Reviews
Francesco Miceli, Maria Virginia Soldovieri, Vincenzo Barrese, Maurizio Taglialatela   +3 more
openaire   +1 more source

Uncovered Contribution of Kv7 Channels to Pulmonary Vascular Tone in Pulmonary Arterial Hypertension [PDF]

Hypertension, 2020
K+ channels play a fundamental role regulating membrane potential of pulmonary artery (PA) smooth muscle cells and their impairment is a common feature in pulmonary arterial hypertension (PAH).
Francisco Pérez-Vizcaíno, Vincenzo Barrese, Laura Moreno   +2 more
exaly   +4 more sources

One man's side effect is another man's therapeutic opportunity: targeting Kv7 channels in smooth muscle disorders

British Journal of Pharmacology, 2013
Retigabine is a first in class anticonvulsant that has recently undergone clinical trials to test its efficacy in epileptic patients. Retigabine's novel mechanism of action - activating Kv7 channels - suppresses neuronal activity to prevent seizure ...
Thomas A Jepps, S P Olesen
exaly   +2 more sources

Some of the next articles are maybe not open access.

Related searches:

Inhibition of Kv7/M Channel Currents by Fangchinoline

Pharmacology, 2022
Introduction: Voltage-gated Kv7/M potassium channels play an essential role in the control of membrane potential and neuronal excitability. Fangchinoline, a bisbenzylisoquinoline alkaloid, displays extensive biological activities including antitumor, anti-inflammatory, and antihypertension effects.
Han Li, DanDan Geng, Rong Zheng, Runmeng Wang, Yaning Li, Yidong Liu, Qingzhong Jia, Fan Zhang   +7 more
openaire   +2 more sources

Kv7 Channels as Targets for the Treatment of Pain

Current Pharmaceutical Design, 2009
Kv7.x channels are a family of six transmembrane domain, single pore-loop, voltage-gated K(+) channels. Five members of the family have been identified to date, including the cardiac channel Kv7.1 (formerly known as KvLQT1) and four neuronal Kv7.x channels, Kv7.2-5. Heteromeric channels containing Kv7.3 and either Kv7.2 or Kv7.5 are thought to underlie
A D, Wickenden, G, McNaughton-Smith
openaire   +2 more sources

Decreased expression of Kv7 channels in Hirchsprung's disease

Journal of Pediatric Surgery, 2017
Voltage-dependent K+ channels (Kv channels) participate in electrical rhythmicity and smooth muscle responses and are regulated by excitatory and inhibitory neurotransmitters. Kv channels also participate in the interstitial cell of Cajal (ICC) and smooth muscle cell (SMC) responses to neural inputs.
Anne-Marie, O'Donnell, David, Coyle, Prem, Puri   +2 more
openaire   +2 more sources