Results 291 to 300 of about 55,792 (321)
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The determination of kynurenine in plasma
Clinica Chimica Acta, 1975A method is described for the estimation of kynurenine in plasma via alkaline cleavage, extraction and diazotisation and coupling. Tryptophan interference, which is demonstrated in an earlier method, has been eliminated. Data on the specificity of the present method and the normal adult male range of fasting plasma kynurenine are presented.
Dennis Risby, Michael H. Joseph
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Epilepsia, 1981
Summary: Recent data and concepts concerning the convulsant effects of kynurenines, neuroactive metabolites of tryptophan, in mice, rats, and frogs are reviewed. Myoclonic seizures of the hindlegs are induced in mice by l‐ and d, l‐kynurenine. Both l‐ and d, l‐kynurenine exhibit a selective synergism with strychnine.
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Summary: Recent data and concepts concerning the convulsant effects of kynurenines, neuroactive metabolites of tryptophan, in mice, rats, and frogs are reviewed. Myoclonic seizures of the hindlegs are induced in mice by l‐ and d, l‐kynurenine. Both l‐ and d, l‐kynurenine exhibit a selective synergism with strychnine.
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Binding of kynurenine to catecholamine [PDF]
Amino Acids, 1992 Papiliochrome II is a pale yellow pigment of butterflies and consists of one molecule each ofL-kynurenine and N-β-alanyldopamine (NBAD). The aromatic amino nitrogen of kynurenine is bonded to theβ-carbon of NBAD. There are isomers IIa and IIb which show opposite circular dichroism.
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The Kynurenines and the Seizures
1996At present, patients with epilepsy are resistant against all antiepileptic drugs in 15–25 per cent of cases. Hence the search for new pathogenetically sound approaches to treatment of this disease. Different neuroactive substances have been studied, of them kynurenines attracting a particular attention.
I. B. Mikhailov +2 more
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The kynurenine system and immunoregulation
Journal of Neural Transmission, 2011There is developing interest in the role of the kynurenines in the immune function. A considerable amount of evidence has accumulated as concerns interactions between the kynurenine pathway, cytokines and the nervous system. Indoleamine 2,3-dioxygenase (IDO) occupies a key position connecting the immune system and the kynurenine pathway.
Mándi Yvette, Vécsei László
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Derivatives of kynurenine as inhibitors of rat brain kynurenine aminotransferase
European Journal of Medicinal Chemistry, 1996Abstract The structural requirements of the catalytic site of kynurenine aminotransferase (KAT), the enzyme responsible for the conversion of l -kynurenine (KYN) to kynurenic acid (KYNA), were examined using analogs and derivatives of KYN. KYNA production from KYN was monitored in rat brain homogenates and brain tissue slices.
Franco Heidempergher +7 more
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T Cell Apoptosis by Kynurenines
2003Indoleamine 2,3-dioxygenase (IDO) is a tryptophan-catabolizing enzyme that, expressed by different cell types, has regulatory effects on T cells resulting from tryptophan depletion in specific local tissue microenvironments. The discovery that inhibition of IDO activity reduces the survival of MHC-mismatched fetuses in mice and that the risk of fetal ...
FALLARINO, Francesca +6 more
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1996
The neuroactivities of kynurenines — the endogenous metabolites of tryptophan have been studied in our laboratory since the begin of 70-ies (ref. see Lapin, 1989). Initially, the major subjects of our pharmacological experiments on mice and rats were the interaction with monoamines (Lapin, 1972–1976) and the convulsant effect of quinolinic acid (QUIN ...
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The neuroactivities of kynurenines — the endogenous metabolites of tryptophan have been studied in our laboratory since the begin of 70-ies (ref. see Lapin, 1989). Initially, the major subjects of our pharmacological experiments on mice and rats were the interaction with monoamines (Lapin, 1972–1976) and the convulsant effect of quinolinic acid (QUIN ...
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Kynurenine and Lipid Metabolism
1991Previous observations showed an increased total cholesterol and triglycerol content and decreased phospholipid and lecithin content in blood serum of patients with elevated kynurenine accumulation in blood serum after tryptophan loading, i.e. in the case of pyridoxal-5-phosphate (P-5-P) deficiency in the organism (Rudzite et al., 1988). The increase of
E. Jurika, V. Rudzite
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Nature, 1966
THE pelage of certain murine rodents contains substantial amounts of fluorescent tryptophan metabolites1. In the laboratory rat l-kynurenine2 is the principal compound present, with relatively small amounts of kynurenic acid, Nα-acetyl-l-kynurenine and other fluorescent compounds.
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THE pelage of certain murine rodents contains substantial amounts of fluorescent tryptophan metabolites1. In the laboratory rat l-kynurenine2 is the principal compound present, with relatively small amounts of kynurenic acid, Nα-acetyl-l-kynurenine and other fluorescent compounds.
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