Results 301 to 310 of about 55,792 (321)
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Measurement of Rat Brain Kynurenine Aminotransferase at Physiological Kynurenine Concentrations
Journal of Neurochemistry, 1991AbstractThe production of the neuroinhibitory and neuroprotective metabolite kynurenic acid (KYNA) was investigated in rat brain by examining its biosynthetic enzyme, kynurenine aminotransferase (KAT). By using physiological (low micromolar) concentrations of the substrate L‐kynurenine (KYN) and by determining the irreversible conversion of [3H] KYN to
Masayuki Nakamura +4 more
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ChemInform Abstract: Inhibitors of the Kynurenine Pathway
ChemInform, 2000AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
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Characterization of human brain kynurenine aminotransferases using [3H]kynurenine as a substrate
Neuroscience, 1993The brain metabolite kynurenic acid is an established broad-spectrum antagonist at ionotropic excitatory amino acid receptors. In the human brain, two distinct enzymes are capable of synthesizing kynurenic acid from its bioprecursor L-kynurenine. Using [3H]kynurenine as the substrate, the two kynurenine aminotransferases (kynurenine aminotransferase I ...
Paolo Guidetti +3 more
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[89] l-Kynurenine and N1-formyl-l-kynurenine
1957Publisher Summary This chapter presents a procedure for the preparation of L-Kynurenine and N-Formyl-L-kynurenine. The principle for preparation of L-kynurenine states L-Tryptophan is acetylated with acetic anhydride by the method of du Vigneaud and Sealock. The N α -acetyl-L-tryptophan is ozonolyzed and hydrolyzed to L-kynurenine and isolated as the
W.E. Knox, V.H. Auerbach
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Kynurenine metabolism in multiple sclerosis
Acta Neurologica Scandinavica, 2005Objective--Excitatory amino acid receptors are involved in the normal physiology of the brain, and may play a role in the pathogenesis of neurological disorders such as Huntington's disease, Parkinson's disease, amyotrophic lateral sclerosis, etc.
Péter Klivényi +6 more
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Kynurenine Aminotransferase in Hypercholesterolemic Rats
1996Nicotinic acid is used in the treatment of atherosclerosis for its hypolipidemic effects (Kritchevsky, 1971; Levy, 1980; Grundy et al., 1981; Altschul et al., 1995), which reduce triglycerides and also cholesterol. In mammals, nicotinic acid derives from the metabolism of tryptophan along the kynurenine pathway.
BERTAZZO, ANTONELLA +5 more
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Role of the Kynurenine Pathway in Stroke
2015Stroke is the second and fifth leading cause of death for people aged >60 and 15–59 years, respectively. Many stroke survivors suffer from chronic health problems that necessitate a long-term process of recovery and rehabilitation. There is increasing evidence that inflammation plays an important role in acute ischemic stroke (AIS), indicating the ...
Ormstad, Heidi, Verkerk, Robert
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[Stress and the kynurenine pathway].
Orvosi hetilap, 2015The kynurenine pathway is the main route of tryptophan degradation which gives rise to several neuroactive metabolites. Kynurenic acid is an endogenous antagonist of excitatory receptors, which proved to be neuroprotective in the preclinical settings. Kynurenines have been implicated in the neuroendocrine regulatory processes.
Majláth Zsófia, Vécsei László
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Kynurenines and Brain Development
2015The mechanisms by which environmental factors such as stress, infection, or inflammation could affect the early brain development of the embryo are largely unknown. One metabolic pathway that could be important is the kynurenine pathway for the oxidative metabolism of tryptophan, since it is activated by each of these factors and it generates an ...
Trevor W. Stone +2 more
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