Results 141 to 150 of about 34,492 (275)

Tryptophan Suppresses FTH1‐Driven Ferritinophagy, a Key Correlate of Prognosis in Hepatocellular Carcinoma

Cell Proliferation, EarlyView.
Intracellular tryptophan levels modulate selective autophagy of FTH1 via the NCOA4 pathway. This autophagic process then inhibits 6‐HMT synthesis, which then results in an increase in reactive oxygen species and ferroptosis. ABSTRACT Hepatocellular carcinoma (HCC) remains a lethal malignancy with limited therapeutic options.
Xinxiang Cheng, Xin Ge, Chi Zhang, Xingye Yang, Zhengxin Yu, Min Zhang, Wen Cao, Qingtao Ni, Yang Liu, Songbing He, Yin Yuan   +10 more
wiley   +1 more source

Stress exposure in the mdx mouse model of Duchenne muscular dystrophy provokes a widespread metabolic response

The FEBS Journal, EarlyView.
A targeted mass spectrometry‐based metabolomics assay was conducted to identify the impact of stress exposure on the regulation of biological stress pathways in the mdx mouse model of Duchenne muscular dystrophy. We demonstrated a broad shift in the circulating stress‐relevant plasma metabolome associated with stressful scruff handling that was ...
Erynn E. Johnson, James M. Ervasti
wiley   +1 more source

The molecular mechanisms of defensive‐grade organic acid biosynthesis in ground beetles

Insect Molecular Biology, EarlyView.
Formic acid and methacrylic acid are the primary defensive chemicals in the pygidial gland secretions of Platynus angustatus and Pterostichus moestus, respectively. Comparative transcriptomics suggests the folate cycle and valine catabolism may be involved in the biosynthesis of formic acid and methacrylic acid, respectively.
Adam M. Rork, Sihang Xu, Athula Attygalle, Tanya Renner   +3 more
wiley   +1 more source

Compositional and Metabolomic Shifts of the Gut Microbiome in Alcohol‐Related Liver Disease

Journal of Gastroenterology and Hepatology, EarlyView.
ABSTRACT Alcohol‐related liver disease (ALD) is a major global health concern characterized by steatosis and liver inflammation due to chronic alcohol consumption. Emerging evidence suggests that ALD is not solely a liver pathology but also involves dysfunction of the gut‐liver axis, where alterations in the gut microbiota play a significant role ...
Cheng‐Hao Kuo, Emad El‐Omar, Cheng‐Yen Kao, Jaw‐Town Lin, Chun‐Ying Wu   +4 more
wiley   +1 more source

Weight Loss‐Associated Remodeling of Adipose Tissue Immunometabolism

Obesity Reviews, EarlyView.
ABSTRACT Obesity is a multifactorial condition characterized by excessive adiposity and systemic chronic low‐grade inflammation. Recent literature reflects a growing appreciation for the complex interplay between metabolism and the immune system in the pathogenesis of obesity‐related health conditions.
Paulo José Basso, Alejandro Schcolnik‐Cabrera, Mengyi Zhu, Erin Strachan, Xavier Clemente‐Casares, Sue Tsai   +5 more
wiley   +1 more source

Neuroimmune pathophysiology of long COVID

Psychiatry and Clinical Neurosciences, EarlyView.
Although COVID‐19 was originally considered a respiratory illness, it is now well established that SARS‐CoV‐2 infection can have far‐reaching impacts on the nervous system. Neurological symptoms such as chemosensory dysfunction are frequently observed during acute infection and approximately 10% of COVID‐19 cases will go on to develop new or persistent
Janna K. Moen, Christopher A. Baker, Akiko Iwasaki   +2 more
wiley   +1 more source

Exhaustive exercise abolishes REV‐ERB‐α circadian rhythm and shifts the kynurenine pathway to a neurotoxic profile in mice

The Journal of Physiology, EarlyView.
Abstract figure legend Acute exhaustive exercise (EE) reduces REV‐ERB‐α protein levels in skeletal muscle, which impairs its transcriptional repression of kynurenine (KYN) 3‐monooxygenase (KMO), a key enzyme in the KYN pathway that converts KYN into potentially neurotoxic metabolites, collectively referred to as ‘kynurenines’. This study identifies KMO
Alisson Luiz da Rocha, Ana Paula Pinto, Ivo Vieira de Sousa Neto, Vitor Rosetto Muñoz, Bruno Brieda Marafon, Lilian Eslaine Costa Mendes da Silva, José Rodrigo Pauli, Dennys Esper Cintra, Eduardo Rochete Ropelle, Fernando Moreira Simabuco, Leandro Pereira de Moura, Ellen Cristini de Freitas, Donato Americo Rivas, Adelino Sanchez Ramos da Silva   +13 more
wiley   +1 more source

Urinary Metabolic Biomarkers of Attentional Control in Children With Attention‐Deficit/Hyperactivity Disorder: A Dimensional Approach Through 1H NMR‐Based Metabolomics

NMR in Biomedicine, Volume 38, Issue 8, August 2025.
This study identified five attentional control subgroups in school‐aged children, with and without ADHD, using VR‐based behavioral tests. NMR metabolomics revealed subgroup‐specific urinary metabolic profiles linked to energy and amino acid metabolism.
Ana del Mar Salmerón, Pilar Fernández‐Martín, Rocío Rodríguez‐Herrera, Francisco Manuel Arrabal‐Campos, Ana Cristina Abreu, Ignacio Fernández, Pilar Flores   +6 more
wiley   +1 more source

Cortisol, Anxiety, and TNFα Mediate the Relationship Between BMI and Executive Functions

Stress and Health, Volume 41, Issue 4, August 2025.
ABSTRACT Overweight and obesity are associated with poorer executive functions (EF). The underlying mechanisms contributing to this relationship are not yet conclusive, but cortisol, anxiety, and inflammation are likely among the contributing factors. Our objective was to evaluate whether fibrinogen, tumour necrosis factor alpha (TNFα), cortisol, and ...
Anna Prunell‐Castañé, María Ángeles Jurado, Xavier Caldú, María José Sender‐Palacios, Consuelo Sánchez Garre, Paloma Salas Gómez‐Pablos, Maite Garolera   +6 more
wiley   +1 more source

Aetiopathogenesis of infantile epileptic spasms syndrome and mechanisms of action of adrenocorticotrophin hormone/corticosteroids in children: A scoping review

Developmental Medicine &Child Neurology, Volume 67, Issue 8, Page 1004-1025, August 2025.
Why does infantile epileptic spasms syndrome (IESS) occur with a variety of underlying conditions and why does it respond to adrenocorticotrophin hormone (ACTH)/corticosteroids? Our scoping review summarizes five hypotheses from the literature: gene/epigenetic regulation, stress/HPA axis activation, neuroinflammation/immune function, altered neuronal ...
Emily A. Innes, Velda X. Han, Shrujna Patel, Michelle A. Farrar, Deepak Gill, Shekeeb S. Mohammad, Russell C. Dale   +6 more
wiley   +1 more source