Results 141 to 150 of about 23,526 (258)

The kynurenine pathway; A new target for treating maternal features of preeclampsia?

, 2019
Stephanie A. Worton, Susan Greenwood, Mark Wareing, Alexander Heazell, Jenny Myers   +4 more
openalex   +1 more source

Neuro‐Immune Crosstalk: Molecular Mechanisms, Biological Functions, Diseases, and Therapeutic Targets

MedComm, Volume 7, Issue 2, February 2026.
Neurons, immune cells, and other cellular components within the disease microenvironment (such as stromal cells and tumor cells) constitute a dynamically evolving ecosystem. Neurons directly modulate immune cell activity and inflammatory responses through the release of neurotransmitters (e.g., norepinephrine and CGRP), while also promoting tumor ...
Xin Guo, Hui Liu, Yu‐Jing Song, Jian‐Hua Wang, Danfeng Liu, Zhi‐Wei Zheng, Jia‐Jun Li, Boya Li, An Song, Wei He, Lei‐Lei Yang, Shuo Wang   +11 more
wiley   +1 more source

Advances in Therapeutic Antibody Discovery and Development Targeting G Protein‐Coupled Receptors

Pharmacology Research &Perspectives, Volume 14, Issue 1, February 2026.
ABSTRACT G protein‐coupled receptors (GPCRs) are integral to numerous biological processes and are associated with various diseases across all therapeutic areas. Consequently, GPCRs present substantial potential for antibody‐based therapies. This review offers an overview of the therapeutic GPCR‐antibody target landscape and examines the diversity ...
Catherine J. Hutchings, Serbülent Ünsal, Mathieu Rappas, Matthew Barnes, Maria Waldhoer, Ben Holland, Martin Culka   +6 more
wiley   +1 more source

A Novel, Robust Method for Quantification of Multiple Kynurenine Pathway Metabolites in the Cerebrospinal Fluid

, 2020
Lilly Schwieler, Ada Trepci, Stanisław Krzyżanowski, Sigurd Hermansson, Mathias Granqvist, Fredrik Piehl, Tomas Venckūnas, Marius Brazaitis, Sigitas Kamandulis, Daniel Lindqvist, A. Daniel Jones, Sophie Erhardt, Lena Brundin   +12 more
openalex   +2 more sources

Supplementary Figure 2 from Circulating Biomarkers of Tryptophan and the Kynurenine Pathway and Lung Cancer Risk

, 2023
Shu‐Chun Chuang, Anouar Fanidi, Per Magne Ueland, Caroline L. Relton, Øivind Midttun, Dan J. Stein, Marc J. Gunter, Michael J. Seckl, Ruth C. Travis, Nicholas J. Wareham, Antonia Trichopoulou, Παγώνα Λάγιου, Dimitrios Trichopoulos, Petra H. Peeters, H. Bas Bueno‐de‐Mesquita, Heiner Boeing, Angelika Wientzek, Tilman Küehn, Rudolf Kaaks, ­Rosario ­Tumino, Claudia Agnoli, Domenico Palli, Alessio Naccarati, Eva Ardanáz, María‐José Sánchez, J. Ramón Quirós, María‐Dolores Chirlaque, Antonio Agudo, Mikael Johansson, Kjell Grankvist, Marie‐Christine Boutron‐Ruault, Françoise Clavel-Chapelon, Guy Fagherazzi, Elisabete Weiderpass, Elio Ríboli, Paul Brennan, Paolo Vineis, Mattias Johansson   +37 more
openalex   +1 more source

Immunostimulatory and Immunodynamic Modeling Analysis to Determine a Plausible Starting Dose of mRNA‐4359 for Use in First‐In‐Human Trials

CPT: Pharmacometrics &Systems Pharmacology, Volume 15, Issue 2, February 2026.
ABSTRACT The investigational antigen‐specific immunotherapy mRNA‐4359 is a lipid nanoparticle–encapsulated mRNA‐based immunotherapy that encodes for the immunogenic indoleamine 2,3‐dioxygenase (IDO) and programmed death‐ligand 1 (PD‐L1) antigens.
Stephen A. Greene, Madhav Channavazzala, Bhairav Paleja, Harshbir Singh Sandhu, Rukmini Kumar, Husain Attarwala, Linh Van, Min Liang   +7 more
wiley   +1 more source

Correlation between plasma and CSF concentrations of kynurenine pathway metabolites in Alzheimer's disease and relationship to amyloid-β and tau

, 2019
Kelly R. Jacobs, Chai K. Lim, Kaj Blennow, Henrik Zetterberg, Pratishtha Chatterjee, Ralph N. Martins, Bruce J. Brew, Gilles J. Guillemin, David B. Lovejoy   +8 more
openalex   +2 more sources

Effects of levetiracetam on astroglial release of kynurenine‐pathway metabolites [PDF]

, 2018
Kouji Fukuyama, Motohiro Okada
openalex   +1 more source

Associations of Parameters of the Tryptophan–Kynurenine Pathway with Cardiovascular Risk Factors in Hypertensive Patients [PDF]

, 2023
Verena Theiler‐Schwetz, Christian Trummer, Martin Grübler, Martin H. Keppel, Armin Zittermann, Andreas Tomaschitz, Winfried März, Andreas Meinitzer, Stefan Pilz   +8 more
openalex   +1 more source

Pathogenesis of Vitiligo: Integrating Immune and Non‐Immune Cell Crosstalk

The Journal of Dermatology, Volume 53, Issue 2, Page 188-199, February 2026.
ABSTRACT Vitiligo is an acquired autoimmune disease characterized by depigmented macules resulting from melanocyte loss. It is a complex multifactorial disorder in which genetic predisposition is combined with environmental factors; however, its detailed etiology remains unclear.
Shintaro Inoue
wiley   +1 more source