Results 151 to 160 of about 1,450,510 (208)

Opioid Modulation of Major Neurotransmitter Systems: Acute, Chronic, and Withdrawal Effects

European Journal of Neuroscience, Volume 64, Issue 9, November 2026.
Opioids are widely used but also frequently misused drugs that affect multiple neurotransmitter systems, including dopaminergic, glutamatergic, GABAergic, serotonergic, and cholinergic pathways. Opioid‐induced neuroadaptations depend on the duration of drug exposure, with distinct changes also emerging following drug discontinuation.
Daniela Novakova, Eliska Pritulova, Jiri Novotny   +2 more
wiley   +1 more source

Editorial Comment on "Stage-Dependent Changes in Kynurenine Pathway Enzyme Expression Suggest Immune-Related Involvement in Bladder Cancer Progression": Rethinking the Tryptophan-Kynurenine Pathway in Urological Cancer Immunotherapy. [PDF]

Int J Urol
Almulla AF, Zhang Y, Maes M.
europepmc   +1 more source

The tryptophan prenyltransferase ComQ from Bacillus subtilis 168 can prenylate daptomycin at Trp1

The FEBS Journal, Volume 293, Issue 21, Page 6413-6425, November 2026.
ComQ168 from Bacillus subtilis 168 catalyzes C‐terminal tryptophan farnesylation of ComX to generate a competence‐inducing pheromone. Recombinant ComQ168 also modifies cyclic peptides, including Daptomycin, likely at the N‐terminal tryptophan. Structural modeling highlights a C‐terminal binding region, supporting substrate promiscuity and establishing ...
Yanli Xu, Maximilian J. L. J. Fürst, Oscar P. Kuipers   +2 more
wiley   +1 more source

Tryptophan metabolism and erectile dysfunction: pathophysiological insights into kynurenine pathway dysregulation. [PDF]

BMC Urol
Özdemi̇r M, Köleli̇ ŞK, Ünlü A, Bi̇k MA, Gül M.   +4 more
europepmc   +1 more source

Methionine Regulates Antitumour Function of CD8+ T Cells Through Polyamine Synthesis

Immunology, Volume 179, Issue 3, Page 418-433, November 2026.
Methionine restriction in vitro enhances CD8+ T cell effector function by suppressing polyamine synthesis and progressively induces the co‐expression of PD‐1 and TIM‐3. Consistently, sustained dietary methionine restriction diminishes the efficacy of adoptive T cell therapy (ACT) and promotes the expression of terminal exhaustion‐associated markers ...
Tian Zhao, Gillian A. Carleton, Sam Preshaw, Sarah MacPherson, Madison Shiyuk, Joseph Monaghan, Jun Han, Oro Uchenunu, Robert Rottapel, Ralph J. DeBerardinis, Kelly M. Stewart, Bo‐Hyun Kim, Juan Ausió, David R. Goodlett, Helena Pětrošová, Kyle D. Duncan, Julian J. Lum   +16 more
wiley   +1 more source

Metabolic Profiling of Circulating and Tumour‐Infiltrating T Cells Uncovers Bioenergetic Checkpoints Linked With Immune and Clinical Skewing in Melanoma Patients

Immunology, Volume 179, Issue 3, Page 486-515, November 2026.
In this study, we revealed the disturbed metabolic status of circulating and tumour‐infiltrating CD4+ and CD8+ T cells in melanoma patients through targeted metabolomic and lipidomic (on sorted subsets) and at single cell level using the SCENITH method.
Hugo Brouque, Kareem Mahdy, Stephane Mouret, Sylvain Henry, Camille Niveau, Mélanie Cettour‐Cave, Martin Pelosse, Florence de Fraipont, Julie Charles, Andrei Turtoi, Philippe Saas, Caroline Aspord   +11 more
wiley   +1 more source

Epilepsy as a Disorder of Neuroimmune Metabolism: The Kynurenine Pathway as a Link Between Cognitive and Psychiatric Dysfunction. [PDF]

Biomolecules
Stone TW, Clanchy FIL, Williams RO.
europepmc   +1 more source

A Single Exercise Session Elicits a Transient Kynurenine Metabolic Signature in Health and Disease: A Systematic Review and Meta‐Analysis

The FASEB Journal, Volume 40, Issue 20, 31 October 2026.
A single exercise session transiently modulates systemic kynurenine pathway metabolism. Immediately after exercise, tryptophan decreases while kynurenine, KYN/TRP, kynurenic acid, and quinolinic acid increase. During recovery, lower tryptophan, higher KYN/TRP, and kynurenic acid remain.
Marcus Vinicius dos Santos Rangel, Gabriela Andrade Paz, Maria das Graças C. Souza, Marie Kupjetz, Tiffany Y. Wences Chirino, Philipp Zimmer, Paulo Farinatti, Juliana Pereira Borges   +7 more
wiley   +1 more source

The kynurenine pathway in RNA virus infection: immunometabolic control of antiviral defense and viral persistence. [PDF]

Front Immunol
Calderón-Sandate DN, Huerta-Garza MJ, Márquez-Reyna BA, Cañedo-Figueroa DM, Hernández-Rodríguez X, Lira-Hernández FI, Osuna-Ramos JF, Cardoso-Ortiz J, Del Ángel RM, Santos-Mena AO, De Jesús-González LA.   +10 more
europepmc   +1 more source

Association Between Kynurenine Pathway and Cerebellar Microstructure in Bipolar Disorder With Childhood Trauma. [PDF]

Alpha Psychiatry
Yin M, Zhang H, Pei H, Zhou R, Lu W, Wu B, Xu T, Wu Y, Du X, Peng D.   +9 more
europepmc   +1 more source