Results 141 to 150 of about 1,450,510 (208)

The microbiome and brain metastasis in non‐small cell lung cancer: A graded appraisal and a framework for prevention‐oriented research

Clinical and Translational Medicine, Volume 16, Issue 11, November 2026.
This Review proposes a microbiome–premetastatic brain niche axis connecting gut, lung, and intratumoral microbes with metabolites, blood–brain barrier remodeling, neuroimmune priming, and brain metastasis in NSCLC. It integrates current evidence while distinguishing established mechanisms from associations and hypotheses requiring prospective and ...
Long Liang, Fangjuan Hu, Xiaofeng Wang, Chunhan Tang, Chun Wang, Gefei Jiang, Chungang Zhao, Yin Zhang, Churong Li   +8 more
wiley   +1 more source

The Efferocytosis‐Driven Macrophage Polarization: A Concerto in the Tumor Immunosuppressive Microenvironment

MedComm, Volume 7, Issue 11, November 2026.
Efferocytosis is a key process for macrophages to clear apoptotic cells, which undergoes the “ Find Me” chemotaxis signal stage, the “eat me” phagocytosis recognition stage and the “digest me” digestion stage in turn. During the aforementioned three stages, various signaling molecules released by apoptotic cells can promote the phenotypic polarization ...
Qiuping Chen, Chunzhi Wu, Changquan Huang, Hang Zhou   +3 more
wiley   +1 more source

Linking protein misfolding and heat stress: a common role for the kynurenine pathway. [PDF]

Metab Brain Dis
Wasike D, Majerova P, Jankech T, Kovac A.   +3 more
europepmc   +1 more source

Gastric Cancer: Epidemiology, Risk Factors, Pathogenesis, Clinical Features, Diagnosis, and Management

MedComm, Volume 7, Issue 11, November 2026.
This comprehensive review summarizes gastric cancer epidemiology, multifactorial risk factors (like infectious, dietary, genetic), pathogenesis such as precancerous evolution, molecular alterations, and a focus on the bidirectional interactions between gastric cancer cells and macrophages in the tumor microenvironment.
Yixuan Xin, Xingya Wang, Yangtao Wu, Qian Liu, Qian Ren, Hui Wang, Jingbo Zhai   +6 more
wiley   +1 more source

Tryptophan-Kynurenine Pathway Metabolites in Women Undergoing Caesarean Delivery. [PDF]

Life (Basel)
Ziętek M, Bieleninik A, Szczuko M, Zagrodnik E, Safranow K, Ułan M, Czerny B, Uzar I.   +7 more
europepmc   +1 more source

Human brain matters: Navigating the neuropathology of COVID‐19

Brain Pathology, Volume 36, Issue 6, November 2026.
Severe COVID‐19 is associated with vascular dysregulation and chronic neuroinflammation, leading to axonal injury and neurodegeneration. In long COVID or PASC, persistent alterations in neuroimaging and biofluid biomarkers reflect ongoing neuronal damage and neuroinflammation, contributing to long‐term neurological symptoms including fatigue, cognitive
Juliana M. Nieuwland, Angelica Scaramuzza, Marianna Bugiani, Wilma D. J. van de Berg, Jinte Middeldorp   +4 more
wiley   +1 more source

Brain viral reservoir seeding and neurological metabolic dysregulation in early‐life immunodeficiency virus infection

Brain Pathology, Volume 36, Issue 6, November 2026.
Brain viral reservoirs were undetectable in neonatal SIV during the first 3 days post infection; antiretroviral therapy (ART) at 3 dpi prevented brain reservoir seeding and normalized metabolic function, highlighting the necessity of very early treatment to protect the developing CNS.
Li Ma, Robert Blair, Yao‐Zhong Liu, Xiaolei Wang, Eunice Vincent, Christopher Yu, Lara A. Doyle‐Meyers, Cissy Zhang, Ahmad Saied, Anne Le, Ronald S. Veazey, Qigui Yu, Huanbin Xu   +12 more
wiley   +1 more source

Janus Reactivity of a Mononuclear Non‐Heme Iron(III)‐Peroxo Complex Toward Indole Oxidation

Angewandte Chemie, Volume 138, Issue 43, 19 October 2026.
The iron(III)‐peroxo complex [FeIII(O2)(12‐TMC)]+ exhibits bifurcating pathways in indole oxidation. N─H indoles undergo N─H H‐atom abstraction, supported by a KIE of 5.2 for N─H/N–D 2,3‐dimethylindoles, whereas N‐methylindoles react via electrophilic addition of the iron‐peroxo group to the C2–C3 double bond of the indole ring, forming iron ...
Wenjuan Zhu, Peng Wu, Binju Wang, Kallol Ray, Wonwoo Nam   +4 more
wiley   +2 more sources

The Tryptophan-Kynurenine Pathway as a Key Mediator of the Gut-Brain Axis in Depression and Alzheimer's Disease. [PDF]

Int J Mol Sci
Procopciuc LM, Hangan AC, Gog-Bogdan S, Lucaciu RL.   +3 more
europepmc   +1 more source

Central and peripheral kynurenine pathway metabolites in COVID-19: Implications for neurological and immunological responses

Long-term symptoms such as pain, fatigue, and cognitive impairments are commonly observed in individuals affected by coronavirus disease 2019 (COVID-19).
Cunningham, Janet L.,, Sellgren, Carl M.,, Virhammar, Johan,, Engberg, Göran,, Kumlien, Eva,, Malwade, Susmita,, Piehl, Fredrik,, Ahlberg Weidenfors, Jacob,, Rostami, Elham,, Orhan, Funda,, Li, Xueqi,, Bergquist, Jonas,, Schwieler, Lilly,, Erhardt, Sophie,, Edén, Arvid,, Malwade, S, Kumlien, Eva, Weidenfors, JA, Bergquist, J, Eden, A, Gisslen, M, Cunningham, Janet L, Orhan, Funda, Piehl, F,, Sellgren, Carl M, Rostami, Elham, Engberg, G,, Li, Xueqi, Schwieler, Lilly, Bergquist, Jonas, Virhammar, Johan, Erhardt, Sophie, Engberg, Göran, Sellgren, CM, Piehl, Fredrik, Weidenfors, Jacob Ahlberg, Cunningham, JL, Malwade, Susmita, Gisslén, Magnus,, Li, X   +39 more
core   +1 more source