Results 141 to 150 of about 1,141,006 (274)

microRNA‐mediated control of cell fate specification and patterning in Marchantia polymorpha

New Phytologist, EarlyView.
The gemma developmental program in Marchantia polymorpha is coordinated by MpMIR166‐mediated repression of MpC3HDZ and auxin homeostasis. Summary MicroRNAs (miRNAs) are small non‐coding RNA molecules essential for growth and development in eukaryotes. In plants, the master gene DICER‐LIKE 1 (DCL1) catalyzes the biogenesis of miRNAs by processing double‐
Adolfo Aguilar‐Cruz, Eduardo Flores‐Sandoval, Ye Xu, Yu Yu, Ximena Gutiérrez‐Ramos, Cristian Y. González‐Rangel, Omar Oltehua‐López, Ana E. Dorantes‐Acosta, Joshua T. Trujillo, Hirotaka Kato, Kimitsune Ishizaki, Rebecca A. Mosher, Liam Dolan, Xuemei Chen, Daniel Grimanelli, Jim Haseloff, John L. Bowman, Mario A. Arteaga‐Vazquez   +17 more
wiley   +1 more source

Microbiome and Metabolomics in Obesity: Advances in Understanding and Interventions Across the Lifespan

Obesity Reviews, EarlyView.
ABSTRACT Obesity arises from intertwined and reciprocal diet‐microbiome‐host pathways that reshape energy balance, insulin sensitivity, and inflammation. This review synthesizes mechanistic links between microbial functions and metabolic control, charts lifestyle‐related lifecourse dynamics from birth to older age, examines how GLP‐1‐based therapies ...
Ioanna Panagiota Kalafati, David Krongauz, Alice Bosco, Antonio Noto, Cristina Piras, Maria Kafyra, Angelica Dessì, Matteo Mauri, Luigi Atzori, Adina Weinberger, Vassilios Fanos, George V. Dedoussis, on behalf of the BETTER4U consortium   +12 more
wiley   +1 more source

Periodontitis and metabolic dysfunction‐associated steatotic liver disease

Periodontology 2000, EarlyView.
Abstract Objective Periodontitis is a chronic inflammatory disease with systemic effects that extend beyond the oral cavity and contribute to systemic immune and metabolic dysregulation. Chronic liver diseases, particularly metabolic dysfunction‐associated steatotic liver disease (MASLD) and its progressive phenotypes, have emerged as major global ...
Rafael Scaf de Molon, Erica Dorigatti de Avila, Davi da Silva Barbirato, Mariana Fampa Fogacci, Jamil Awad Shibli, Anton Sculean, Alpdogan Kantarci   +6 more
wiley   +1 more source

Metabolic reprogramming of the immune response in periodontitis

Periodontology 2000, EarlyView.
Abstract Objective Periodontitis, a highly prevalent chronic inflammatory disease, is characterized by the progressive destruction of the tooth‐supporting tissues, ultimately causing tooth loss. In recent years, the emerging field of immunometabolism has revealed that immune cell function is tightly regulated by intracellular metabolic pathways that ...
Rafael Scaf de Molon, Melissa Grant, Iain Chapple, Joao Paulo Steffens   +3 more
wiley   +1 more source

Predictive value of kynurenine pathway metabolites in the severity of patients with obsessive-compulsive disorder

Background: Obsessive-compulsive disorder (OCD) is a psychiatric condition characterized by repetitive thoughts and behaviors. The kynurenine pathway has been increasingly implicated in psychiatric disorders.
Alp, Hamit Hakan, Kurhan, Faruk, Akbay, Halil İbrahim   +2 more
core   +1 more source

Translating gut microbiome research into therapies for type 1 diabetes

Experimental Physiology, EarlyView.
Abstract Type 1 diabetes (T1D) is characterised by the loss of functional pancreatic β‐cells, for which lifelong insulin therapy remains the standard of care. Given that the gut microbiome can influence host health and that shifts in gut microbial profiles have been observed in T1D, growing interest has emerged in the role of the gut microbiome in T1D,
Shanti P. Kok, Max Nieuwdorp, Elena Rampanelli   +2 more
wiley   +1 more source

Intramuscular pathways of maladaptation in overtraining syndrome

The Journal of Physiology, EarlyView.
Abstract figure legend The transition from adaptive overreaching to maladaptive overtraining and mechanisms through which excessive training load can lead to performance decline. Four interconnected pathophysiological domains are highlighted: neural fatigue, involving both central and peripheral components such as altered sensory feedback and reflex ...
Emily Shorter, Oscar Horwath, Sabrina Tzivia Barsky, Ferdinand von Walden, Johanna T. Lanner   +4 more
wiley   +1 more source

Longitudinal Associations Between Inflammation and Multi‐Dimensional Fatigue up to 2 Years After Colorectal Cancer Diagnosis

International Journal of Cancer, Volume 159, Issue 10, Page 2437-2451, 15 November 2026.
Cancer‐related fatigue (CRF) is a common and debilitating symptom among colorectal cancer (CRC) patients, but its underlying biological causes remain unclear, with inflammation emerging as a leading suspect. Here, researchers analyzed inflammatory biomarkers in blood samples and evaluated responses in fatigue assessments from CRC patients at and up to ...
Anouk E. C. Bruijnzeels, Floortje Mols, Katrijn Van Deun, Dounya Schoormans   +3 more
wiley   +1 more source

Kynurenine pathway in bipolar disorder

, 2018
Bipolar disorder (BD) is a chronic psychiatric illness which, among other things, is characterized by cerebral dysfunctions, cognitive disorders and sleep disturbances. The neurobiological basis of these processes remains unclear.
Papageorgiou, C.C., Angelopoulos, E., Konstantinou, G.   +2 more
core   +1 more source

Trophoblast Extracellular Vesicles Rewire Immunity: A Symptom‐Relief Avenue for Recessive Dystrophic Epidermolysis Bullosa

Journal of Extracellular Vesicles, Volume 15, Issue 10, October 2026.
First‐trimester trophoblast EVs are enriched in anti‐inflammatory proteins, lipids, and immunoregulatory miRNAs. EVT‐EVs reprogram monocytes toward a pro‐resolving phenotype and restore immune homeostasis in RDEB, supporting their potential as offering a scalable off‐the‐shelf therapy for chronic inflammatory diseases.
Nell Hirt, Enzo Manchon, Ming Wu, Helene Le Buanec, Pauline Bataille, Emmanuelle Bourrat, Jean‐David Bouaziz, Nabila Jabrane‐Ferrat, Reem Al‐Daccak   +8 more
wiley   +1 more source