Results 211 to 220 of about 23,526 (258)

The Power Struggle: Kynurenine Pathway Enzyme Knockouts and Brain Mitochondrial Respiration. [PDF]

J Neurochem
Juhász L, Spisák K, Szolnoki BZ, Nászai A, Szabó Á, Rutai A, Tallósy SP, Szabó A, Toldi J, Tanaka M, Takeda K, Ozaki K, Inoue H, Yamamoto S, Ono E, Boros M, Kaszaki J, Vécsei L.   +17 more
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Exhaustive exercise abolishes REV-ERB-α circadian rhythm and shifts the kynurenine pathway to a neurotoxic profile in mice. [PDF]

J Physiol
da Rocha AL, Pinto AP, de Sousa Neto IV, Muñoz VR, Marafon BB, da Silva LECM, Pauli JR, Cintra DE, Ropelle ER, Simabuco FM, de Moura LP, de Freitas EC, Rivas DA, da Silva ASR.   +13 more
europepmc   +1 more source

Exercise-induced adaptations in the kynurenine pathway: implications for health and disease management. [PDF]

Front Sports Act Living
Rangel MVDS, Lopes KG, Qin X, Borges JP.
europepmc   +1 more source

Elevated brain manganese induces motor disease by upregulating the kynurenine pathway of tryptophan metabolism. [PDF]

Proc Natl Acad Sci U S A
Warden AS, Sharma N, Hutchens S, Liu C, Haggerty NR, Gurol KC, Jursa T, Smith DR, Dayne Mayfield R, Mukhopadhyay S.   +9 more
europepmc   +1 more source

The Kynurenine Pathway in Gut Permeability and Inflammation. [PDF]

Inflammation
Kearns R.
europepmc   +1 more source

Assessment of Kynurenine Pathway Enzyme Activity in Ocular Diseases: Associations with Cataract, Diabetes, Glaucoma, and Pseudoexfoliation Syndrome. [PDF]

J Clin Med
Zemitis A, Vanags J, Klavins K, Laganovska G.   +3 more
europepmc   +1 more source

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Inhibitors of the kynurenine pathway

European Journal of Medicinal Chemistry, 2000
Strokes (intracranial thomboses or haemorrhaging) cause death and disability, but effective treatments are lacking. The metabolism of tryptophan leads to the generation of quinolinic acid, an agonist potentially neurotoxic at glutamate receptors, and kynurenic acid, an antagonist at the same population of receptors.
openaire   +2 more sources

Kynurenine Pathway Enzymes in Guinea pigs

2003
In some animals, the administration of repeated doses of tryptophan can cause death. It has been reported that guinea pig does not survive repeated doses of tryptophan, due to the absence of the hormonal induction mechanism of liver tryptophan 2,3-dioxygenase (TDO).
ALLEGRI, GRAZIELLA, COSTA, CARLO VIRGILIO LUIGI, RAGAZZI, EUGENIO, BERTAZZO, ANTONELLA, BIASIOLO M.   +4 more
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Kynurenine pathway abnormalities in Parkinson's disease

Neurology, 1992
We measured metabolites of tyrosine and tryptophan (TRP) in the frontal cortex, putamen (PT), and pars compacta of the substantia nigra (SN) of control and Parkinson's disease (PD) brain tissues. Dopamine concentrations were significantly decreased in the PT and SN of PD tissue, regardless of L-dopa therapy. However, 3-O-methyldopa (3OMD) concentration
T, Ogawa, W R, Matson, M F, Beal, R H, Myers, E D, Bird, P, Milbury, S, Saso   +6 more
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