Results 201 to 210 of about 1,141,006 (274)

Tissue‐Resident Macrophage in Inflammation and Cancer

MedComm, Volume 7, Issue 9, September 2026.
Opposing macrophage functions in inflammation and cancer converge on shared mechanistic nodes, informing cross‐disease therapeutic strategies. ABSTRACT Tissue‐resident macrophages (TRMs) are long‐lived immune cells strategically distributed across organs, where their functional plasticity enables both homeostatic maintenance and pathological ...
Siyuan Huang, Jiangbo Fan, Wenyi Liu, Di Liu, Rui Wang, Yuanyang Wang, Jianhui Sun, Huacai Zhang, Qingli Cai, Zhe Xu, Fang Xu, Jianxin Jiang, Zhen Wang, Ling Zeng   +13 more
wiley   +1 more source

Contextual Regulation of the Kynurenine Pathway and Its Relevance for Personalized Psychiatry. [PDF]

J Pers Med
Murata S, Oxenkrug G, Halaris A.
europepmc   +1 more source

Oxidative and Antioxidant Systems in Ferroptosis of Cancer: Mechanisms, Regulations, and Therapeutic Targeting

MedComm – Oncology, Volume 5, Issue 3, September 2026.
Ferroptosis is governed by the balance between reactive oxygen species (ROS)‐driven lipid peroxidation and a multi‐tiered antioxidant network. ROS sources include mitochondrial electron transport chain, voltage‐dependent anion channels, NADPH oxidases, and endoplasmic reticulum‐resident oxidoreductases, while antioxidant defenses span the primary GSH ...
Deepak K, Pritam Kumar Roy, Maniklal Shee, Budhaditya Mukherjee, Aoife Ward Gahlawat, Mahitosh Mandal   +5 more
wiley   +1 more source

Kynurenine Pathway, Nrf2 and NF-κB Cross-Regulation in the CNS: An Overview. [PDF]

Mol Neurobiol
Cerdán-Centeno KT, González-Soto AY, Lares-López V, Sánchez-Vázquez LD, Tapia-Estrada HR, Túnez I, López-Goerne TM, Tinkov AA, Aschner M, Santamaría A.   +9 more
europepmc   +1 more source

Nitric Oxide in Cancer: Mechanisms, Dual Role, and Therapeutic Strategies

MedComm – Oncology, Volume 5, Issue 3, September 2026.
Nitric oxide exerts concentration‐dependent dual roles in cancer, functioning as either a tumor promoter or suppressor. This review comprehensively examines NO's multifaceted regulation of tumor biology, including S‐nitrosylation signaling, metabolic reprogramming, immunemodulation, and therapy resistance, and highlights emerging therapeutic strategies
Jia Shao, Honghua Zhang, Jingyu Chen, Ziyu Qian, Ning Zhang, Yihua Zhang, Hui Ye, Jianbing Wu, Zhangjian Huang   +8 more
wiley   +1 more source

Targeted metabolomics to assess positive effects of empagliflozin in a Parkinson's disease model: focused on the kynurenine pathway and oxidative stress. [PDF]

Sci Rep
Lénárt I, Horváth O, Molnár K, Bereczki C, Monostori P, Klivényi P, Galla Z.   +6 more
europepmc   +1 more source

Circadian rhythms and chronotherapy in Alzheimer's disease: Mechanisms and therapeutic implications

Neuroprotection, Volume 4, Issue 3, Page 229-247, September 2026.
Circadian dysregulation contributes to Alzheimer's disease through sleep disruption, clock‐gene dysfunction, neuroinflammation, impaired proteostasis, and metabolic imbalance. These alterations promote cognitive decline and disease progression, while circadian biomarkers and chronotherapeutic interventions offer opportunities for precision diagnosis ...
Bivek Singh, Filippo Pigazzani, Roberto Manfredini   +2 more
wiley   +1 more source

Changes in kynurenine pathway metabolites and brain structure in response to behavioral activation therapy. [PDF]

Brain Behav Immun
Youn C, Ford BN, Akeman E, Martell C, Paulus MP, Savitz J, Aupperle RL.   +6 more
europepmc   +1 more source

Post‐Omicron cognitive decline is largely reversible: Two‐year multicenter cohort study of domain‐specific outcomes in hospitalized patients

Neuroprotection, Volume 4, Issue 3, Page 248-261, September 2026.
Earlier variants of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS‐CoV‐2), including the original strain, Alpha and Delta, were linked to significant and persistent cognitive impairment. The long‐term cognitive impact of Omicron infection, however, has remained uncertain. This study shows that post‐Omicron cognitive decline is largely reversible,
Min Qiu, Mengwen Wang, Shengcai Chen, Wenbo Zuo, Jiashuo Lin, Luojinyun Wang, Senwei Tan, Quanwei He, Yanan Li, Huijuan Jin, Xuan Niu, Wanli Li, Fengguang Li, Ming Huang, Yan Wan, Bo Hu   +15 more
wiley   +1 more source