Results 201 to 210 of about 2,991,386 (293)

Psychobiotics and the microbiota–gut–brain axis: Emerging paradigms in mental health modulation

Experimental Physiology, Volume 111, Issue 5, Page 2449-2463, 1 May 2026.
Abstract The global rise in mental health conditions has prompted interest in interventions that act beyond conventional psychopharmacology. Psychobiotics, broadly understood as live microorganisms or microbe‐derived products that interact with the microbiota–gut–brain axis, have been suggested to exert neuroactive effects through neural, immune ...
Amir Arsalan Ghahari, Mehrdad Nourizadeh, Mehrdad SalekShahabi, Shaghayegh Davari, Saeid Mohammadzadeh Mounesyar   +4 more
wiley   +1 more source

Kynurenine Pathway Dysregulation in Parkinson's Disease: Insights for Disease Modulation and Therapy. [PDF]

Int J Tryptophan Res
Chakkarwar VA, Kulkarni YA.
europepmc   +1 more source

Modulating IDO1 and TDO Inhibition Through Structural Modification of Diaryl Hydroxylamines

ChemMedChem, Volume 21, Issue 7, 14 April 2026.
Diaryl hydroxylamines have emerged as promising scaffolds for targeting the tryptophan‐catabolizing enzymes indoleamine 2,3‐dioxygenase 1 (IDO1) and tryptophan 2,3‐dioxygenase (TDO), key drivers of tumor immune escape. Building on the reported dual IDO1/TDO inhibitory activity of O‐((3,5‐difluorophenyl)(phenyl)methyl)hydroxylamine, a series of diaryl ...
Angeliki S. Foscolos, Alexandros Pappas, Christos N. Petroulias, Anna Kapella, Georgia M. Prifti, Grigoris Zoidis, Minas Papadopoulos, Anastasia Mpakali, Aristeidis Chiotellis   +8 more
wiley   +1 more source

Special issue: The kynurenine pathway in aging

Experimental Gerontology, 2020
Mark W, Hamrick, Carlos M, Isales
openaire   +2 more sources

The Impact of Clinical Variables and Dialysis Modality on Kynurenine Pathway Enzymes Expression. [PDF]

Int J Mol Sci
Zakrocka I, Wicha-Komsta K, Boczkowska S, Kloc R, Kocki T, Urbańska EM, Załuska W, Kronbichler A.   +7 more
europepmc   +1 more source

Nexus of IDO1/Kynurenine Pathway to T-Cell Exhaustion: Hypoxia-Induced Tryptophan Metabolism in Glioblastoma. [PDF]

Metabolites
Abikenari M, Nageeb G, Ha JH, Sjoholm MA, Liu J, Bergsneider B, Valenzuela J, Poe J, Bog Cho K, Verma R, Wu C, Sanker V, Medikonda R, Kim LH, Choi J, Banu MA, Lim M.   +16 more
europepmc   +1 more source

Physical Activity, Metabolic Dysfunction, and the Kynurenine Pathway in Endometriosis and Polycystic Ovary Syndrome: A Literature Review. [PDF]

Biomolecules
Varga N, Kis-György R, Ajkay-Donáth L, Tapody ZI, Vágvölgyi-Sümegi E, Körtési T, Nagy-Grócz G.   +6 more
europepmc   +1 more source

The potential role of kynurenines in Alzheimer’s disease: pathomechanism and therapeutic possibilities by influencing the glutamate receptors [PDF]

, 2014
Majláth Zsófia, Toldi József, Vécsei László   +2 more
core   +1 more source

Persons With Multiple Sclerosis Reveal Distinct Kynurenine Pathway Metabolite Patterns: A Multinational Cross-Sectional Study. [PDF]

Neurol Neuroimmunol Neuroinflamm
Kupjetz M, Langeskov-Christensen M, Riemenschneider M, Inerle S, Ligges U, Gaemelke T, Patt N, Bansi J, Gonzenbach RR, Reuter M, Rosenberger F, Meyer T, McCann A, Ueland PM, Eskildsen SF, Emil Nygaard MK, Joisten N, Hvid L, Dalgas U, Zimmer P.   +19 more
europepmc   +1 more source

The kynurenine pathway in relation to depression and anhedonia symptom severity among women with HIV. [PDF]

Brain Behav Immun Health
Gabbay V, Hills C, Cardozo F, Chance AB, Sharma A, Mowrey W, Baker Z, Qi Q, Burgess HJ, Berman JW, Gange SJ, Gustafson DR, Weber KM, French AL.   +13 more
europepmc   +1 more source