Results 191 to 200 of about 2,991,386 (293)

Effectiveness of Melatonin‐Containing Foods on Promoting Sleep: A Scoping Review

Food Science &Nutrition, Volume 14, Issue 5, May 2026.
Effectiveness of melatonin‐containing foods promoting sleep: A scoping review. ABSTRACT Melatonin plays a crucial role in managing the body's sleep–wake cycle, and its natural occurrence in certain foods has generated interest in dietary interventions to improve sleep.
Tanzeela Nisar, Andrea Fuller, Prajwal Gyawali, Stephen Bird   +3 more
wiley   +1 more source

The Kynurenine Pathway: a Proposed Mechanism Linking Diabetes and Periodontal Disease in Diabetic Patients

Dental Hypotheses, 2011
Introduction: Diabetes mellitus is a metabolic disease characte-rized by dysregulation of carbohydrate, protein and lipid metabolism. Diabetes could result, in part, in activation of tryptophan metabolism.
Rishabh Kapila, KS Nagesh, Asha R. Iyengar, Subash BV. Adiga   +3 more
doaj  

Society and the Microbiome: A Biopsychosocial Window Into Comprehensive Well‐Being: A Review

Health Science Reports, Volume 9, Issue 5, May 2026.
ABSTRACT Background and Objectives In addition to biological factors, human social behavior, societal structures, and environmental contexts significantly influence the human microbiome. This review examines how socially relevant factors relate to the microbiome to clarify underlying mechanisms and health impacts, aiming to inform effective preventive ...
Jing Li, Yang Yang, Yufeng Wang, Ji'An Liu, Xufeng Huang, Zhengrui Li, Ju Li   +6 more
wiley   +1 more source

A Distinct Tryptophan Metabolic Phenotype Marks Severe Fatigue in Quiescent Crohn's Disease

JCC Plus, Volume 1, Issue 3, May 2026.
ABSTRACT Background Fatigue is a common and debilitating symptom in inflammatory bowel disease (IBD), but its underlying mechanisms remain unclear. Altered tryptophan metabolism may contribute to fatigue. Tryptophan is metabolized through the kynurenine, serotonin, and indole pathway, involving host and microbial processes. We aimed to explore the link
Paula I. Metselaar, Mees J. van der Hoff, Naomi V. Wieser, Olaf Welting, Antoine Lefèvre, Camille Dupuy, Patrick Emond, Joep P. M. Derikx, Wouter J. de Jonge, Geert R. A. M. D'Haens, Anje A. te Velde, Mark Löwenberg, Mohammed Ghiboub   +12 more
wiley   +1 more source

Kynurenine Pathway, Nrf2 and NF-κB Cross-Regulation in the CNS: An Overview. [PDF]

Mol Neurobiol
Cerdán-Centeno KT, González-Soto AY, Lares-López V, Sánchez-Vázquez LD, Tapia-Estrada HR, Túnez I, López-Goerne TM, Tinkov AA, Aschner M, Santamaría A.   +9 more
europepmc   +1 more source

Contextual Regulation of the Kynurenine Pathway and Its Relevance for Personalized Psychiatry. [PDF]

J Pers Med
Murata S, Oxenkrug G, Halaris A.
europepmc   +1 more source

Advancing IBD Management: A Literature Review on the Role of Non‐Invasive Blood‐Based Biomarkers in Predicting and Assessing Pharmacodynamic Response to Treatment

Clinical and Translational Science, Volume 19, Issue 5, May 2026.
ABSTRACT Reliable biomarkers that enable noninvasive, longitudinal assessment of disease activity and therapeutic response remain a major unmet need in inflammatory bowel disease (IBD). While colonic biopsies are the gold standard for evaluating mucosal inflammation, their invasive nature and limited spatial and temporal resolution constrain their ...
Mohamed Hassanein, Li Xi, Rathi D. Ryan, Zhan (Harold) Ye, Nessy Tania, Yamato Sano, Joshua Varghese, Diogo Branquinho, Anna Sapone   +8 more
wiley   +1 more source

The tryptophan-kynurenine pathway in cardiovascular diseases: mechanistic insights and therapeutic opportunities. [PDF]

Front Cardiovasc Med
Chen W, Shui M, Wei Z, Gao W, Liu X, Lei Q.   +5 more
europepmc   +1 more source

Stage‐Dependent Changes in Kynurenine Pathway Enzyme Expression Suggest Immune‐Related Involvement in Bladder Cancer Progression

International Journal of Urology, Volume 33, Issue 5, May 2026.
ABSTRACT L‐tryptophan (Trp) metabolism through the L‐kynurenine (Kyn) pathway contributes to immune escape in neoplasms, including bladder cancer (BC). Indoleamine 2,3‐dioxygenase‐1 (IDO1) is a key enzyme, and its catabolites—Kyn, 3‐hydroxykynurenine (3HK), and 3‐hydroxyanthranilate (3HAA)—depend on other enzymes and play a crucial role in ...
Douglas Edgard Lemes, Aline Áurea de Souza Santos, Jéssica Lopes de Oliveira, Henrique Roman‐Ramos, Ana Carolina Ramos Moreno, Cleber Pinto Camacho, José Pontes‐Junior, Humberto Dellê   +7 more
wiley   +1 more source

Kynurenine pathway metabolites are increased in inflammatory depression and decrease with omega-3 treatment. [PDF]

Brain Behav Immun Health
Lindahl J, Söderberg Veibäck G, Suneson K, Blanking W, Tjernberg J, Ståhl D, Wiman Å, Ventorp F, Erhardt S, Lindqvist D.   +9 more
europepmc   +1 more source