Results 81 to 90 of about 23,526 (258)

Hepatic steatosis induced in C57BL/6 mice by a non-ß oxidizable fatty acid analogue is associated with reduced plasma kynurenine metabolites and a modified hepatic NAD+/NADH ratio

Lipids in Health and Disease, 2020
Background Non-alcoholic fatty liver disease is often associated with obesity, insulin resistance, dyslipidemia, and the metabolic syndrome in addition to mitochondrial dysfunction and nicotinamide adenine dinucleotide (NAD+) deficiency.
Rolf K. Berge, Daniel Cacabelos, Rosa Señarís, Jan Erik Nordrehaug, Ottar Nygård, Jon Skorve, Bodil Bjørndal   +6 more
doaj   +1 more source

Intestinal microbiome alterations in pediatric epilepsy: Implications for seizures and therapeutic approaches

Epilepsia Open, EarlyView.
Abstract The intestinal microbiome plays a pivotal role in maintaining host health through its involvement in gastrointestinal, immune, and central nervous system (CNS) functions. Recent evidence underscores the bidirectional communication between the microbiota, the gut, and the brain and the impact of this axis on neurological diseases, including ...
Teresa Ravizza, Greta Volpedo, Antonella Riva, Pasquale Striano, Annamaria Vezzani   +4 more
wiley   +1 more source

Involvement of Kynurenine Pathway Between Inflammation and Glutamate in the Underlying Etiopathology of CUMS-Induced Depression Mouse Model [PDF]

, 2022
Xingying Wu, Bowen Chen, Di Zhong, Shuo Jiang, Haipeng Xu, Mengting Shi, Rong Hu, Shaopeng Sun, Zhujin Song, Jiapeng Liu, Ruijie Ma, Qin Guo   +11 more
openalex   +1 more source

Ketogenic diet for infantile epileptic spasms

Epilepsia Open, EarlyView.
Abstract Approximately half of all cases of Infantile Epileptic Spasms Syndrome (IESS) do not respond to vigabatrin and hormonal therapies. There is no clear consensus as to the second‐line therapy for IESS. Ketogenic diet (KD) has emerged as an effective treatment for certain drug‐resistant epilepsies and in many cases of IESS.
Morris H. Scantlebury, Anamika Choudhary, Andy Cheuk‐Him Ng, Cezar Gavrilovici   +3 more
wiley   +1 more source

A distinct profile of tryptophan metabolism along the kynurenine pathway downstream of Toll-like receptor activation in irritable bowel syndrome

Frontiers in Pharmacology, 2012
Irritable bowel syndrome (IBS), a disorder of the brain-gut axis, is characterised by the absence of reliable biological markers. Tryptophan is an essential amino acid that serves as a precursor to serotonin but which can alternatively be metabolised ...
Gerard eClarke, Gerard eClarke, Gerard eClarke, Declan P McKernan, Gabor eGaszner, Eamonn M Quigley, Eamonn M Quigley, John F Cryan, John F Cryan, Timothy G Dinan, Timothy G Dinan   +10 more
doaj   +1 more source

Modulating the Kynurenine pathway or sequestering toxic 3-hydroxykynurenine protects the retina from light induced damage in Drosophila [PDF]

, 2022
Sarita Hebbar, Sofia Traikov, Catrin Hälsig, Elisabeth Knust   +3 more
openalex   +1 more source

Bioengineered Isoflavone–Probiotic Functional Foods for Sustainable Modulation of Metabolic and Reproductive Health in PCOS

Food Bioengineering, EarlyView.
Synergistic isoflavone‐probiotic action modulated metabolic, microbial and ovarian pathway ABSTRACT Polycystic ovary syndrome (PCOS) is a prevalent metabolic–endocrine disorder characterized by insulin resistance, hyperandrogenism, chronic inflammation, oxidative stress, and ovarian dysfunction, with growing evidence implicating gut microbiota ...
Jeyavelkumaran Renukadevi, Panneerselvam Sneha, Dhanapal Saravanan Mridula, Keerthivasan Nimithasree, Valliappan Sanjay   +4 more
wiley   +1 more source

Lithium inhibits tryptophan catabolism via the inflammation-induced kynurenine pathway in human microglia [PDF]

, 2020
Ria Göttert, Pawel Fidzinski, Larissa Kraus, Ulf C. Schneider, Martin Holtkamp, Matthias Endres, Karen Gertz, Golo Kronenberg   +7 more
openalex   +1 more source

Host–microbiota interaction drives 5‐hydroxyindole‐3‐acetic acid production to promote linear growth in infant mice

iMetaOmics, EarlyView.
This study discovered that Lactiplantibacillus plantarum Hi188 promoted linear growth in postweaning mice. Transcriptomic analysis, untargeted metabolomics, and in vitro experiments showed that the elevated levels of 5‐hydroxyindole‐3‐acetic acid (5‐HIAA) activated the hepatic aryl hydrocarbon receptor (AhR) and subsequently promoted insulin‐like ...
Yongmei Yang, Jing Yang, Weiyao Zhang, Linghao Zhou, Chenxu Zhu, Xuguang Zhang, Yuejian Mao, Meiling Zhang   +7 more
wiley   +1 more source

Supplementary Figure 3 from Circulating Biomarkers of Tryptophan and the Kynurenine Pathway and Lung Cancer Risk

, 2023
Shu‐Chun Chuang, Anouar Fanidi, Per Magne Ueland, Caroline L. Relton, Øivind Midttun, Dan J. Stein, Marc J. Gunter, Michael J. Seckl, Ruth C. Travis, Nicholas J. Wareham, Antonia Trichopoulou, Παγώνα Λάγιου, Dimitrios Trichopoulos, Petra H. Peeters, H. Bas Bueno-de-Mesquita, Heiner Boeing, Angelika Wientzek, Tilman Küehn, Rudolf Kaaks, ­Rosario ­Tumino, Claudia Agnoli, Domenico Palli, Alessio Naccarati, Eva Ardanáz, María‐José Sánchez, J. Ramón Quirós, María‐Dolores Chirlaque, Antonio Agudo, Mikael Johansson, Kjell Grankvist, Marie‐Christine Boutron‐Ruault, Françoise Clavel-Chapelon, Guy Fagherazzi, Elisabete Weiderpass, Elio Ríboli, Paul Brennan, Paolo Vineis, Mattias Johansson   +37 more
openalex   +1 more source