Results 111 to 120 of about 13,672,018 (258)

Editorial: Pharmacology of L-Arginine and L-Arginine-Rich Food

Frontiers in Pharmacology, 2021
Burkhard Poeggeler, Horst Robenek, Miguel A. Pappolla   +2 more
doaj   +1 more source

Oral L-Arginine treatment attenuates Cryptococcus neoformans extrapulmonary dissemination and disease progression

Virulence
Cryptococcus neoformans is an opportunistic fungal pathogen causing severe infections in immunocompromised individuals. Arginine metabolism is critical for immune regulation, but its precise role in cryptococcal pathogenesis is not well understood.
Adithap Hansakon, Pakkapong Phucharoenrak, Dunyaporn Trachootham, Suticha Kaewrattana, Siranart Jeerawattanawart, Warisraporn Tangchang, Methee Chayakulkeeree, Nasikarn Angkasekwinai, Pornpimon Angkasekwinai   +8 more
doaj   +1 more source

Advanced Materials for Biologics Delivery to Brain Tumors

Advanced Materials, EarlyView.
Material innovation is central to unlocking the therapeutic potential of biologics against many central nervous system diseases, including brain cancer. By engineering carriers with controlled transport, targeting, and release properties, advanced materials can overcome the blood–brain barrier and tumor microenvironment, improving the delivery of ...
Yuran Feng, Yuxue Cao, Maria Kavallaris, Taskeen Janjua, Amirali Popat   +4 more
wiley   +1 more source

Inhibition of L-arginine transport in platelets by asymmetric dimethylarginine and N-G-monomethyl-L-arginine: Effects of arterial hypertension

, 2004
1. Nitric oxide (NO) produced by human platelets plays an important role in all stages of platelet activation. L-Arginine, the precursor for NO synthesis, modulates NO production by platelets.
Siqueira, M A S, Rozentul, A L, Mann, G E; id_orcid, Moss, M B, Ellory, J C, Meirelles, L R, Mendes-Ribeiro, A C, Brunini, T M C, de Moura, R S   +8 more
core   +1 more source

Electrospun nanofibrous scaffold modification by L-Arginine [PDF]

, 2018
Cílem této práce byl vývoj, výroba a testování materiálů určených k hojení kožních poranění a použití pro kardiovaskulární systém. Pro testování byly vyrobeny nanovlákenné polykaprolaktonové vrstevy s aktivní složkou, viz grafický abstrakt.
Oulehlová, Zuzana
core   +1 more source

Self‐Assembling Copolymers Encapsulating Single Endothelial Cells Induce Endogenous ECM Deposition and Vascular Regeneration

Advanced Materials, EarlyView.
This study presents the first demonstration of stable sub‐50‐micron single‐cell GPM vesicles fabricated through the intrinsic self‐assembly of an amphiphilic copolymer. Hierarchical assembly of cell containing GPM vesicles into microspheres enable tunable, sustained cell delivery with immune protection.
Viola B. Morris, Sangho Lee, Kalp Soni, Simon He, Matthew Huang, Dandan Chen, Dae Hoon Lee, Kyung Hee Kim, Seonggeon Cho, Laura Pencea, Divit Jain, Young‐Sup Yoon   +11 more
wiley   +1 more source

L-arginine attenuates platelet reactivity in hypercholesterolemic rabbits.

, 1994
Platelets are capable of producing nitric oxide (NO) through the L-arginine-NO synthase pathway. Acute exposure to supraphysiological concentrations of L-arginine in vitro increases the production of NO by platelets and is associated with an increase in ...
G Theilmeier, L L Leung, P S Tsao, J P Cooke, A H Singer   +4 more
core   +1 more source

L-ornithine supplementation in periodontitis treatment yields greater benefits than L-arginine after one year: Part II of a randomized controlled pilot study

Complementary Therapies in Medicine
Background: L-arginine and L-ornithine have previously shown limited short-term immunological benefits in the treatment of periodontitis. The aim of this study was to assess the extended efficacy and durability of the response to L-arginine or L ...
Viktoriya I. Shynkevych, Svitlana V. Kolomiiets, Kristina O. Udaltsova, Igor P. Kaidashev   +3 more
doaj   +1 more source

3D‐Printed Corneal Substitutes: Materials, Fabrication, and Preclinical Progress

Advanced Materials Technologies, EarlyView.
Successful clinical translation of 3D‐printed corneal substitutes relies on the interplay between the bioink properties, cellular component, and the fabrication process. These factors influence the critical properties of the construct, including optical transparency, mechanical stability, suture retention, that ultimately govern long‐term stromal ...
Shadi Moshayedi, Ashley Vazquez, Alexander J. Choi, Dimitrios Karamichos, Jayoung Kim   +4 more
wiley   +1 more source

Phosphorylation‐Facilitated CKB Lactylation At K11 By GCN5 Enhances Creatine Kinase Activity and Mitigates Neuronal Damage After Cerebral Ischemia‐Reperfusion

Advanced Science, EarlyView.
This study uncovers hierarchical coordination between K11 lactylation and S199 phosphorylation of CKB in cerebral ischemia‐reperfusion injury. Such dual modifications potentiate CKB enzymatic function, remodel energy metabolism, alleviate oxidative stress and neuronal damage, and represent a viable therapeutic target for stroke treatment.
Chao Duan, Ruolin Zhang, Shihui Ding, Ying Feng, Tao Shen, Ziwei Wang, Wendai Bao, Ke Shui, Jun Qin, Jun Chen, Min Zhang, Zijing Ren, Dongmei Zhao, Xingrong Guo, Zhibing Ai, Xin Yang, Peiyang Zhou, Zhiqiang Dong   +17 more
wiley   +1 more source