Results 71 to 80 of about 13,672,018 (258)

L-arginine therapy in Raynaud's phenomenon?

, 1992
Since L-Arginine is the substrate for nitric oxide synthesis by vascular endothelial cells the effects of L-arginine treatment on the digital vascular response to local stimuli were investigated in patients with primary or secondary Raynaud's phenomenon.
B. Bottasso, M. L. Biondi, A. Agostoni, B. Marasini, A. Cazzaniga, M. Cugno, C. Bassani   +6 more
core   +1 more source

Dose‐dependent hepatotoxicity of hydrogen peroxide in HepG2 cells and its modulation by CYP450 induction

FEBS Open Bio, EarlyView.
NMR metabolomics revealed concentration‐dependent metabolic perturbations in HepG2 cells exposed to H2O2. Rifampicin pretreatment enhanced metabolic competence, attenuated toxin‐induced alterations and produced metabolite profiles more consistent with human liver physiology, supporting the use of CYP450‐induced HepG2 models for improved in vitro ...
Maren Jinks, Garth L. Maker, Emily C. Davies, Berin A. Boughton, Samantha Lodge   +4 more
wiley   +1 more source

Chronic L-arginine treatment improves metabolic, cardiovascular and liver complications in diet-induced obesity in rats

, 2013
l-Arginine is an important dietary amino acid in both health and disease, especially of the cardiovascular system. This study has determined whether dietary supplementation with l-arginine attenuates cardiovascular, metabolic, pancreatic and liver ...
Alam, Md. Ashraful, Withers, Kerry, Brown, Lindsay, Sernia, Conrad, Kauter, Kathleen   +4 more
core   +1 more source

Involvement of Nitric Oxide in Microcirculatory Reactions after Ischemia-Reperfusion of the Rat Urinary Bladder [PDF]

, 2009
Background: Nitric oxide ( NO) plays a role in inflammation. Our aim was to investigate the role of NO in the microcirculatory changes after ischemia-reperfusion (I/R) of the bladder using intravital videomicroscopy (IVM).
Bajory, Z., Pajor László, Kiraly, I., Szabó Andrea, Messmer Konrad, Király István, Pajor, L., Bajory Zoltán, Messmer, K., Szabo, A.   +9 more
core   +1 more source

Structural studies and functional engineering of NanX: an anhydro‐sialic acid transporter from Escherichia coli

FEBS Open Bio, EarlyView.
Biophysical characterisation shows that NanX, a membrane transport protein from the major facilitator superfamily (MFS), forms both monomers and dimers after purification. AlphaFold modelling and substrate docking provide information on residues likely involved in substrate recognition for NanX and another MFS member, NanT.
Michael C. Newton‐Vesty, Kelsi R. Hall, Zachary D. Tillett, Liam S. Turk, James S. Davies, Michael J. Currie, Hamish G. Brown, Sepideh Valimehr, Peter D. Mace, Andrew E. Whitten, Santosh Panjikar, Eric Hanssen, Rachel A. North, Renwick C.J. Dobson   +13 more
wiley   +1 more source

In silico and in vitro exploration of a tyrosinase for biocatalytic production of catechols

FEBS Open Bio, EarlyView.
Tyrosinase from Ralstonia pseudosolanacearum is a promising biocatalyst for producing valuable catechols from monophenol substrates. This tyrosinase is uniquely suited to this due to its high monophenolase : diphenolase ratio. We combined in silico docking and in vivo kinetic characterisation of this tyrosinase with 11 industrially relevant monophenols,
James Britton, Fang Zhao, Reeta Davis, Meg Walsh, Kevin E O'Connor, David O'Connell, Tanja Narancic   +6 more
wiley   +1 more source

Arginine-mediated dissociation of single cells and cell sheets from a polystyrene culture dish

, 2019
Here, we report a novel non-enzymatic cell dissociation method, based on our finding that adherent cells dissociate rapidly from the polystyrene culture dish when incubated in an l- or d-arginine-containing solution.
Hisakage Funabashi (1645843), Hajime Shigeto (1645846), Kohei Ichikawa (7343024), Ryuichi Hirota (463874), Akio Kuroda (123856), Takeshi Ikeda (463875), Takenori Ishida (463871)   +6 more
core   +1 more source

Adenosine triphosphate as a modulator of protein interactions and stability

FEBS Open Bio, EarlyView.
ATP is best known as the cell's energy currency, but it also shapes how proteins fold, interact, aggregate and form biomolecular condensates. This review explains the emerging physical principles behind these effects, including weak binding to charged protein regions, magnesium‐dependent behaviour and concentration‐dependent control of protein ...
Shuyuan Tan, Robin Curtis
wiley   +1 more source

Stereochemistry of guanidine-metal interactions: Implications for L-arginine-metal interactions in protein structure and function

, 2006
The geometries of 150 guanidine-metal ion interactions retrieved from crystal structures deposited in the Cambridge Structural Database have been analyzed.
Flores Jr. L. V., Christianson D. W., Di Costanzo L.   +2 more
core   +1 more source

Antifungal Activities of L-Methionine and L-Arginine Treatment In Vitro and In Vivo against Botrytis cinerea

Microorganisms
Gray mold caused by Botrytis cinerea is a common postharvest fungal disease in fruit and vegetables. The prevention and treatment of postharvest gray mold has been one of the hot research issues addressed by researchers.
Shengwang Li, Youwei Yu, Peng Xie, Xianran Zhu, Chao Yang, Linjing Wang, Shaoying Zhang   +6 more
doaj   +1 more source